A5102799295- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Galectins and Cancer Biology
- Helicobacter pylori-related gastroenterology studies
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Genetic Syndromes and Imprinting
- Gastric Cancer Management and Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Prenatal Screening and Diagnostics
- Ion Transport and Channel Regulation
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Aquatic and Environmental Studies
- Genetic factors in colorectal cancer
Shenzhen Second People's Hospital
2024
Key Laboratory of Guangdong Province
2024
Guangzhou Medical University
2024
Nantong University
2019-2023
Affiliated Hospital of Nantong University
2019-2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Jingzhou Central Hospital
2020-2022
Yangtze University
2020-2022
Zhejiang University
2017-2021
Hyperactivation of Wnt/β-catenin signaling is one the major causes human colorectal cancer (CRC). A hallmark Wnt nuclear accumulation β-catenin. Although β-catenin import and export have been widely investigated, underlying mechanism β-catenin's retention remains largely unknown. Here, we report that Twa1/Gid8 a key factor for during carcinogenesis. In absence Wnt, Twa1 exists together with in Axin complex undergoes ubiquitination degradation. Upon signaling, translocates into nucleus, where...
Abstract The fine structures, enzyme histochemical, and immunohistochemical characterization of liver in zebrafish were investigated using light microscopy electron microscopy. results showed that was separated into three lobes each lobe had a central vessel comparable to the mammalian vein. However typical hepatic lobules, portal areas, arteries not observed. A vein entered its tributaries connected directly sinusoids, which then converged vessel. Three vessels finally carried blood out...
Lenvatinib is an orally administered drug that works as a multi-targeted tyrosine kinase inhibitor. It has been approved first-line after sorafenib in hepatocellular carcinoma (HCC). However, little currently known about its treatment, targets, and possible resistance HCC.The proliferation of HCC cells was evaluated using colony formation, 5-ethynyl-2'-deoxyuridine (EDU), wound healing, cell counting kit-8 (CCK-8), xenograft tumor assays. RNA sequencing (RNA-seq) utilized to comprehensively...
Gastric intestinal metaplasia (GIM) is a precancerous gastric carcinoma (GC) lesion with pivotal roles in carcinogenesis. CD24, LGR5 and Ki67 are expressed GIM; we previously demonstrated that aquaporin 3 (AQP3) goblet cells positively correlated GIM severity. However, the relationships of AQP3 classification other proteins, their transition from to remain unknown. Sixteen patients intestinal-type GC were enrolled this study. was determined according updated Sydney system; via HID-AB...
BACKGROUND:Long non-coding RNAs (lncRNAs) play key roles in the development and progression of diseases, including sepsis. Therefore, this study aimed to clarify role underlying molecular mechanisms lncRNA NEAT1 MATERIAL AND METHODS:We used real-time quantitative polymerase chain reaction (RT-qPCR) analyze expression nuclear paraspeckle assembly transcript 1 (NEAT1), let-7b-5p, tumor necrosis factor receptor-associated 6 (TRAF6). Western blot assay was measure protein levels. After treatment...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, with unclear pathogenesis. Sphingomyelin phodiesterase acid-like 3A (SMPDL3A) affects cell differentiation and participates in immune regulation. However, its molecular biological function HCC has not yet been elucidated. Data from 180 patients were analyzed relationship between expression SMPDL3A liver cancer tissues prognosis patients. Crispr-Cas9 dual vector lentivirus was used to knock out lines. The...
Abstract Background and Aims Hepatocellular carcinoma (HCC) is a malignant tumour associated with high morbidity mortality rates worldwide. Recently, TRPM8 was reported to play an important role in progression. However, the precise of HCC remains unclear. In this study, we explored expression levels, molecular functions underlying mechanisms HCC. Methods Tissue samples were used analyse assess its diagnostic value for prognosis. Cell Counting Kit‐8, EdU colony formation assays performed...
Background: Persistent Helicobacter pylori (H.pylori) infection leads to various gastric diseases.Multiple studies have demonstrated that aryl hydrocarbon receptor (AHR) plays roles in the antibacterial response and repressor (AHRR) is downregulated stomach cancer.However, role of AHR or AHRR H. pylori-related diseases remains unclear.Aims: To investigate whether involved diseases.Methods: Patients with gastritis adenocarcinoma were enrolled randomly, tissue specimens diagnosed...
Growing evidence has shown that genetic or epigenetic alterations are highly involved in the initiation and progression of renal cell carcinoma (RCC). This study aimed to find prognostic methylation markers clear RCC (ccRCC).In this study, we developed confirmed an integrated comprehensive signature by integrating DNA methylation, gene expression, The Cancer Genome Atlas (TCGA) survival data. First, was found checked based on data analysis published datasets. Then, independent predictive...
ABSTRACT Pneumonia is a common respiratory disease worldwide. Long noncoding RNAs have been implicated in the pathogenesis of pneumonia. However, effect and mechanism long intergenic nonprotein-coding RNA (LINC00707) on pneumonia were still unclear. Lipopolysaccharide (LPS) reduced cell viability promoted apoptosis inflammation MRC-5 cells. LINC00707 was increased, miR-223-5p decreased LPS-treated knockdown relieved LPS-triggered injury directly interacted with through acting as sponge....
The mortality rate for liver cancer is high worldwide. etiology of has altered with the incidence non-alcoholic fatty disease (NAFLD) although effective vaccination strategies have been developed. Therefore, it important to discover new biomarkers diagnosis and prognosis. Aquaporin 9 (AQP9) reported in some cancers, especially cancer, its role this malignancy remains be clarified. In study, we conducted a bioinformatics analysis clarify function AQP9 cancer.Immunohistochemistry, real-time...
The dysregulated long non-coding RNA (lncRNA) small nucleolar host genes (SNHGs) have been demonstrated to be involved in gastric carcinogenesis and progression; however, the role of SNHG17 carcinoma remains investigated. We aimed ascertain expression tissues cell lines, investigate its mechanistic this malignancy.The levels SNHG17, P15, P16, P18, P19 cyclin dependent kinases-4 (CDK4) were determined by real-time quantitative polymerase chain reaction (RT-qPCR) and/or western blotting human...
Ubiquitin-related modifier 1 (URM1) is a member of the ubiquitin-like regulator family, which acts as post-translational protein in oxidative emergency response mechanism. Previous studies have shown that URM1 may be involved process apoptosis and play role JNK signaling pathway. In this study, we aimed to investigate possible mechanism HCC progression.Expression was determined 90 pairs matched liver cancer adjacent non-cancerous tissues by immunohistochemistry. The impacts on cell...
Liver cancer is one of the major causes death worldwide, incurring high mortality and a significant financial burden on healthcare system. Abnormal RNA-binding proteins (RBPs) have been found to be associated with carcinogenesis in liver cancer. Among these, motif protein 12 (RBM12) located exon junction complex (EJC). The goal this study was determine what role RBM12 plays hepatocellular carcinoma (HCC) from biological perspective.The Tumor IMmune Estimation Resource (TIMER) Human Protein...
Globally, one of the dominant causes cancer-related mortality is liver cancer. Identification potent biomarkers for initial stage diagnosis and prognosis a key factor to ensure efficient therapy reduce rate in cancer patients. REXO4 has been reported neuropathic pain familial isolated pituitary adenoma (FIPA), however, its relationship with still elusive.In an attempt scrutinize expression cancer, Oncomine, TCGA databases were analyzed. Real-time PCR was employed identify mRNA levels 45...
Background: Hepatocellular carcinoma (HCC) is a leading cause of global cancer-related mortality and the most common form liver cancer. REXO4 (RNA exonuclease 4 homolog) downregulation has previously been linked to enhanced chemosensitivity in breast cancer cells. The present study sought comprehensively clarify functional role HCC. Methods: expression levels HCC tumor tissues control tissue samples were established by analyzing data from Gene Expression Omnibus (GEO) database. was then...