A5016279200- High-Velocity Impact and Material Behavior
- Structural Response to Dynamic Loads
- Pneumonia and Respiratory Infections
- Perovskite Materials and Applications
- Luminescence Properties of Advanced Materials
- Salivary Gland Disorders and Functions
- Oral health in cancer treatment
- Fire effects on concrete materials
- Endodontics and Root Canal Treatments
- Geomechanics and Mining Engineering
- Pediatric health and respiratory diseases
- Hydraulic flow and structures
- Metal Forming Simulation Techniques
- Soil, Finite Element Methods
- Immune Response and Inflammation
- Solid-state spectroscopy and crystallography
- Advanced Sensor and Energy Harvesting Materials
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Berberine and alkaloids research
- Concrete Corrosion and Durability
- Natural Compounds in Disease Treatment
- Nanoplatforms for cancer theranostics
- Optical properties and cooling technologies in crystalline materials
First Affiliated Hospital Zhejiang University
2020-2024
Beijing University of Agriculture
2024
Nanning Normal University
2024
Sun Yat-sen Memorial Hospital
2019
Sun Yat-sen University
2019
Prince of Wales Hospital
2018
Nantong University
2018
Second People's Hospital of NanTong
2018
Chongqing Medical University
2015-2017
Institute of Process Engineering
2017
Interaction between virulence factors of streptococcus pneumoniae and innate immune receptors elicits host responses through specific signaling pathways during infection. Insights into the events may provide a better knowledge starting for host-pathogen interaction. Here we demonstrated significant induction response elicited by recombinant endopeptidase O (rPepO), newer pneumococcal protein, both in vivo vitro. Intratracheal instillation rPepO protein resulted increase cytokines production...
Recurrent aphthous stomatitis remains the most common disease of oral mucosa. The aim this study was to investigate clinical significance serum interleukin-6, interleukin-17A, and tumor necrosis factor-alpha in recurrent stomatitis.Using flow cytometry analysis, we detect level interleukin-2, factor-alpha, interferon-gamma 127 patients with 20 healthy control cases; compare; analyze correlation each index.The levels group were higher than group, differences statistically significant (P <...
Lung tissue cells play an active role in the pathogenesis of pulmonary inflammatory diseases by releasing a variety cytokines and chemokines. However, how lung respond to microbial stimuli during infections remains unclear. In this study, we found that patients with community-acquired pneumonia displayed increased IL-27 levels bronchoalveolar lavage fluid serum. We subsequently examined immunopathological mechanisms for activation primary human fibroblasts bronchial epithelial IL-27....
ABSTRACT Insights into the host-microbial virulence factor interaction, especially immune signaling mechanisms, could provide novel prevention and treatment options for pneumococcal diseases. Streptococcus pneumoniae endopeptidase O (PepO) is a newly discovered ubiquitously expressed protein. A PepO-mutant strain showed impaired adherence to invasion of host cells compared with isogenic wild-type strain. It still unknown whether PepO involved in defense response infection. Here, we...
The present paper investigates the enhancement of therapeutic effect Paclitaxel (a potent anticancer drug) by increasing its cellular uptake in cancerous cells with subsequent reduction cytotoxic effects. To fulfill these goals (PTX)-Biotinylated PAMAM dendrimer complexes were prepared using biotinylation method. primary parameter Biotinylated a terminal HN2 group - degree was evaluated HABA assay. basic integrity complex studied DSC. Drug Loading (DL) and Release (DR) parameters...
The influence of labyrinth seal structure on leakage behaviour in a reciprocating compressor was addressed this paper. effects the main parameters, such as tooth angle, sealing clearance, and cavity depth, were compared using FLUENT software iterative calculation results. Simulations process with internal size performance different structures conducted to explore characteristics fluid flow. By comparing simulations fluid- interaction experience formula calculations, results revealed validity...
This study aims to provide valuable insight into the irrigation in curved root canals with CFD method. Numerical simulation of flow originated from a side-vented or an open-ended flat needle located prepared canal two different insertion depths was performed. The distribution velocity, wall shear stress, apical pressure, and detailed structures were all evaluated. results show that both side port portion target tends make circumferentially non-symmetric stress asymmetrical streamlines....
Introduction: Oral mucositis (OM) is a common and debilitating side effect of cancer therapies such as radiotherapy, chemotherapy, hematopoietic cell transplant, or their combinations. Method: This study focused on the reparative effects human embryonic stem cell-derived mesenchymal cells (hESC-MSCs) in OM possible mechanisms. An ulcer model was created rat buccal mucosa to mimic an vivo animal mucosal injury, hESC-MSCs were injected 48h later assess effects. In vitro, efficacy regulating...
An experimental system is designed by combining the split Hopkinson pressure bar (SHPB) with microwave heating device, based on stress wave theory, availability of experiment technique analyzed. Tests concrete whose temperature changes from room to 650°C and impact velocity 5m/s 12m/s are completed for first time high-temperature dynamical damaging phenomena obtained. Based data analysis, mechanical behavior high affected not only strain rate effect influence keeps decreasing increasing, but...
An experimental system of high-temperature split Hopkinson pressure bar (SHPB) was developed by combination the and microwave heating system, then tests concrete whose temperature changed from room to 650°С impact velocity 5m/s 12m/s were completed. Based on test results, dynamic strength increases with increasing whether high or temperature, meanwhile has strain rate effect, but effect keeps decreasing increasing, even at above 500°С , compressive will not have sensitive any longer when...
<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic progressive disease characterised by synovial inflammation, autoantibody production, cartilage and bone destruction. Bone erosions are key feature of RA reflecting both severity progression. An imbalance between Th17 regulatory T cells (Treg cells) has been extensively recognised in patients model animals RA. Oral administration berberine, an isoquinoline alkaloid, showed to ameliorate various symptoms autoimmune diseases including...
This article established strain characterization of damage factor equation concrete in elastic stage, and completed the specimens dynamic ‘freezing in’ test. A series under rate had been gotten, characteristics impact load was analysed. The evolution process material related to both size size, development showedf a power function relation. Then used describe materials could be fitted.
Using microwave heating method to establish a set of effective technology about uniaxial compression test concrete, and obtain the experiment phenomenon concrete when temperature is 16 -650 . Experiment results indicate that damaged by high temperature, strength decreases, peak strain increases, elastic modulus decreases. Based on data, unified equation was putted forward describe relation between compressive strength, strain, temperature. While, stress curve, analysis shows it gradually...