Periodontal ligament stem cells (PDLSCs) with bone morphogenic ability are used to treat diseases such as periodontitis. Their treatment potential is increased when in combination proteins that induce osteogenic differentiation. For example, morphogenetic protein-9 (BMP9) has been found have potent activity. In the present study, PDLSCs were isolated from human periodontal membrane and infected recombinant adenoviruses expressing BMP9 (Ad-BMP9). Levels of markers runt-related transcription...

Abstract Early childhood caries (ECC) is the most common chronic disease in young children. Its reported prevalence varies greatly across China. This systematic review aimed to explore epidemiological characteristics of ECC mainland China from 1987 2013. In total, 102 articles were included. The pooled national and care index (ft/dmft%) for 65.5% 3.6%, respectively. overall declined 77.9% during 1987–1994 56.4% 2010–2013. children aged 1–6 years was 0.3%, 17.3%, 40.2%, 54.4%, 66.1% 70.7%,...

As China opens up to the world, so its domestic markets become available. The Chinese people have money and desire for foreign goods, it is widely predicted that by year 2020 their country's economic power will be greater than of USA. This book analyzes changes within from a consumer level. author examines cultural factors drive people, outlining how they affect business environment suggesting strategies companies exploit potential this enormous market.

Dental follicle stem cells are a group of possessing osteogenic, adipogenetic and neurogenic differentiations, but the specific mechanism underlying multilineage differentiation remains still unclear.Great attention has been paid to bone morphogenetic protein-9 (BMP-9) due its potent osteogenic activity.In present study, rat dental were isolated purified, passage 3 underwent adenovirus mediated BMP-9 gene transfection prepare with stable expression.Detection alkaline phosphatase (ALP)...

Abstract Tanshinone IIA ( TAN ) is one of the major functional compounds Salvia miltiorrhiza Bunge and possesses ability to suppress growth multiple cancer cell types via its apoptosis‐ autophagy‐inducing functions. In this study, effect therapy on survival oral squamous carcinoma OSCC was evaluated, underlying mechanism involved in treatment investigated. Human SCC ‐9 used for vitro assays induction an xenograft mouse model. The tumor cells were subjected administration at different...

Abstract While associations between periodontitis and an elevated risk of cancer have been suggested, the results existing observational studies inconsistent, also leaving room for further investigation into underlying mechanisms. This study was designed to delve possible causal link 20 standard cancers while concurrently identifying potential mediators. We initiated a Mendelian randomization analysis that drew from either publicly accessible or personally obtained genome-wide association...

Abstract Cells, scaffolds, and growth factors play important roles in bone regeneration. Bone morphogenetic protein 9 (BMP9), a member of BMP family, could facilitate osteogenesis by regulating promoting angiogenesis. Similar to other stem cells, rat dental follicle cells (rDFCs), the precursor cementoblasts, osteoblasts periodontal ligament can self-renew exhibit multipotential capacity. Coralline hydroxyapatite (CHA) has good biocompatibility conductivity required for tissue engineering....

Abstract The traditional focus of IT operations no longer meets the challenges tomorrow's fast-changing business environment. in new millennium, CIOs will be required to shift their from internal information processing external processing. By taking on role "corporate antenna" and generating intelligence that matters, will, for first time history, start exercise its true strategic corporate operations.

Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors with a low quality life. Because traditional surgical treatment often causes large wounds and then affects life patients, it urgent to find new efficient drugs good safety for clinical treatment. This study aimed identify potential anticancer starting from Chinese medicine Salvia miltiorrhiza extract. Cryptotanshinone, compound isolated herb miltiorrhiza, was found significantly induce apoptosis inhibit...

Reservoir bank landslides are a frequent phenomenon, and the stability of these is affected by two essential factors: rainfall reservoir level changes. Studying response patterns landslide movements to variables crucial in preventing their occurrence mitigating effects. To this end, study employed 103 European Space Agency (ESA) Copernicus Sentinel-1 images SBAS-InSAR (small baseline subset interferometric synthetic aperture radar) technique obtain time series Guobu slope deformation from...

The application of bioengineering techniques for achieving bone regeneration in the oral environment is an increasingly prominent field. However, clinical use synthetic materials carries certain risks. liquid phase concentrated growth factor (LPCGF), as a biologically derived material, exhibits superior biocompatibility. In this study, LPCGF was employed tissue engineering scaffold, hosting dental follicle cells (DFCs) to facilitate regeneration. Both vivo and vitro experimental results...

Rat dental follicle cells (rDFCs) function as precursor of periodontal tissues. Bone morphogenetic protein (BMP9) plays an important role in proliferation and differentiation. Tumour necrosis factor-alpha (TNF-alpha) is contributor to bone resorption. Wnt canonical pathway can be inhibited by Dickkopf 1 (DKK1). The aim the study was enhance osteogenesis BMP9 treated rDFCs inflammatory environment elucidate mechanism.rDFCs were infected adenoviruses expressing (adBMP9). Expression levels...

Periodontitis is a chronic infectious disease that alters the cellular microenvironment and promotes bone absorption. Bone morphogenetic protein 9 (BMP9) serves an important role in proliferation differentiation, tumor necrosis factor‑alpha (TNF‑α) contributor to resorption. The present study aimed investigate effect of osteogenic differentiation presence BMP9 TNF‑α rat follicle stem cells (rDFCs). rDFCs were transfected with adenoviruses expressing (AdBMP9) expression levels proteins [BMP9,...

Several studies have evaluated the correlation between glutathione S-transferase mu-1 (GSTM1), GST theta-1 (GSTT1) polymorphisms and oral cancer in Chinese people. However, results are inconsistent. To assess effects of GSTM1, GSTT1 null genotypes on risk for development population, a meta-analysis was performed.Studies were identified using PubMed databases through February 2016. The associations assessed with pooled odds ratios (ORs) 95% confidence intervals (CIs).This included six 1306...

Building reconstruction using high-resolution satellite-based synthetic SAR tomography (TomoSAR) is of great importance in urban planning and city modeling applications. However, since the imaging mode side-by-side, TomoSAR point cloud a single orbit cannot achieve complete observation buildings. It difficult for existing methods to extract same features, as well use overlap rate alignment homologous cross-source cloud. Therefore, this paper proposes robust method clouds areas. First, noise...

The Laxiwa hydropower station reservoir in the upper reaches of Yellow River basin is located a canyon zone. Due to its complex terrain and difficult transportation, traditional monitoring methods are implement this area, especially during critical deformation stage when personnel may face danger or encounter difficulty reaching site. To achieve long-term continuous dynamic upstream active slope station, namely Guobu slope, SBAS-InSAR technology has been adopted as replacement for...