A5114417926- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- COVID-19 Clinical Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Research Studies
- Long-Term Effects of COVID-19
- Medical Research and Treatments
- Liver physiology and pathology
- COVID-19 and healthcare impacts
- FOXO transcription factor regulation
- Cardiovascular Health and Disease Prevention
- Brain Metastases and Treatment
- Blood Pressure and Hypertension Studies
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Cardiac Imaging and Diagnostics
- Pain Mechanisms and Treatments
- Hepatitis B Virus Studies
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- Boron Compounds in Chemistry
- Healthcare and Venom Research
- Vagus Nerve Stimulation Research
Union Hospital
2024
Huazhong University of Science and Technology
2024
Dalian Medical University
2024
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Second Military Medical University
2016-2020
Renmin Hospital of Wuhan University
2020
Wuhan University
2020
Shanghai Tenth People's Hospital
2016-2018
Tongji University
2018
Abstract Background An elevated serum C-reactive protein (CRP) level was observed in most patients with coronavirus disease 2019 (COVID-19). Methods Data for COVID-19 clinical outcome a designated hospital Wuhan, China, were retrospectively collected and analyzed from 30 January 2020 to 20 February 2020. The prognostic value of admission CRP evaluated COVID-19. Results Of 298 enrolled, 84 died 214 recovered. Most nonsurvivors male, older, or chronic diseases. Compared survivors, showed...
Abstract Background Elevated serum C-reactive protein (CRP) level was observed in most patients with COVID-19. Methods Data of COVID-19 clinical outcome a designated hospital Wuhan, China, were retrospectively collected and analyzed from Jan 30 to Feb 20, 2020. The prognostic value admission CRP evaluated Results Out 298 enrolled, 84 died 214 recovered. Most non-survivors tended be males, old aged, or chronic diseases. Compared survivors, showed significantly elevated white blood cell...
Abstract Background Since Dec 2019, SARS-CoV-2 has caused about fifty thousand patients and over two deaths in Wuhan, China. We reported characteristics of with COVID-19 during epidemic ongoing outbreak Wuhan. Methods Data clinical outcome a designated hospital were retrospectively collected from electronic medical records. Characteristics compared between who died or recovered, different disease severity. Results By Feb 25, 2020, 403 enrolled, 100 303 recovered. Most non-survivors tended to...
Abstract While associations between periodontitis and an elevated risk of cancer have been suggested, the results existing observational studies inconsistent, also leaving room for further investigation into underlying mechanisms. This study was designed to delve possible causal link 20 standard cancers while concurrently identifying potential mediators. We initiated a Mendelian randomization analysis that drew from either publicly accessible or personally obtained genome-wide association...
Sorafenib is a multi-kinase blocker and one of the few suggested drug treatments for aggressive hepatocellular carcinoma (HCC) patients. However, resistance to sorafenib may often occur over time cause further tumor aggression. Recently, cancer stem cells were found in HCC speculated be involved progression. SOX9 highly expressed promotes cell proliferation self-renewal. Meanwhile, patients with higher expression show poorer prognosis. Whether still unclear. Here, we that treatment increased...
Objective: To compare of carotid-femoral pulse wave velocity (cf-PWV) and brachial-ankle PWV (ba-PWV) in the association with conventional cardiovascular risk factors target organ damages (TODs).Design method: 1599 community-dwelling elderly subjects (age>65 years old) northern Shanghai were recruited from June 2014 to August 2015. Cf-PWV ba-PWV measured by SphygmCor (AtCor, Australia) VP1000 (Omron, Japan), respectively. Under framework comprehensive examinations, assessed, hypertensive...
Objective To evaluate the effects of combined vagus nerve electric stimulation postconditioning and limb remote ischemic on myocardial ischemia-reperfusion (I/R) injury in rats.Methods One hundred male SD rats aged 8 weeks weighing 250-350 g were randomly allocated into 5 groups ( n =20 each):sham operation group (group S); I/R group; POES) ; RP) + POES-RP).Myocardial was induced by occlusion left anterior descending branch (LAD) coronary artery for 30 min followed 120 reperfusion...
Objective To evaluate the protective effects of fentanyl postconditioning and remote limb ischemic (RLIP) against myocardial ischemia-reperfusion (I/R) injury in rats. Methods Thirty-nine male SD rats aged 8 weeks weighing 250-350 g were randomly allocated into 5 groups: Ⅰ group sham operation (group S, n = 5); Ⅱ I/R ( 7); Ⅲ F, n= 9); Ⅳ RLIP R, 9) Ⅴ + F-R, 9). The animals anesthetized with intraperitoneal 3% pentobarbital 50 mg/kg, intubated mechanically ventilated. Myocardial was induced by...
Objective To compare the effects of ischemic preconditioning versus postconditioning on myocardial ischemia-reperfusion （I/R）-induced inflammatory response in rats. Methods Forty male SD rats weighing 290-320 g were randomly divided into 4 groups （ n = 10 each）： Ⅰ group sham operatin （group S）; Ⅱ I/R; Ⅲ IPC） and Ⅳ IPOC）.Myocardial I/R was induced by 30 min ligation left anterior descending branch （LAD） coronary artery followed reperfusion. In IPC preceded 3 cycles ischemia reperfusion （each...
Objective To investigate the role of cyclooxygenase-2(COX-2)and mitochondrial adenosine tuiphosphate sensitive potassium channels (mito-KATP channels) in sufentanil preconditioning-induced delayed cardiopreteetion against myocardial ischemia-reperfnsion (I/R) injury rats. Methods Seventy-two adult male Wistsr rats weighing 250-300 g were randomly divided into 6 groups ( n =12 each). Group Ⅰ,Ⅱ,Ⅲ preconditioned with intraperitoneal (IP) normal saline (NS) 1 ml/kg while group Ⅳ,Ⅴ,Ⅵ IP 20 μg/kg...
Objective To evaluate influences of fentanyl and sufentauil on the cardioprotection effect preemptive levothyroxine-sodium administration in rats. Methods Immature rats were randomly allocated into seven groups (n=8):blank control group (group BC),control C),levothyroxine-sodium 10 μg group(group μg),fentanyl F),sufentanil S),combined F+L) combined sufentanil S+L).The isolated heart model was established with a Langendorff apparatus.Hearts F F+L perfused KH fluid containing 30 μg/L,and...
Objective: To investigate and compare the associations of pulse pressure amplification (PPA) augmentation index (Aix) with asymptomatic cardiac structural functional damage in an elderly Chinese population.Design method: 1940 participants (mean age 71.6 years) were included present study. Central blood (BP) parameters measured by SphygmoCor device. PPA Aix calculated as ratio central brachial pressures aortic pressure, respectively. Cardiac including left ventricular mass (LVMI), peak early...
Objective: High blood pressure (BP) promotes the development of hypertensive target organ damage (TOD). As BP goal 130/80 mmHg is now under debated, whether thresholds and 140/90 differs in patterns TOD remains unclear. This analysis focusing on relationships between different groups TOD. Design method: nested Northern Shanghai Study (NSS, Clinicaltrials.gov NCT02368938), participants prospectively recruited from June 2014 to 2017 [n = 2098, 45.52% men, aged 71.3 ± 6.1 years]. Preclinical...
Abstract Background The 2019 novel coronavirus (SARS-CoV-2) has caused an outbreak in the world. critically ill patients had a high mortality. However, possible risk factors of critical with disease (COVID-19) are not fully known. We aim to investigate COVID-19 and address their role predicting progression.Methods In this single-centered, retrospective, observational study, we enrolled 91 adult Renmin Hospital Wuhan University between Jan 20, 2020 Feb 28, 2020. Data were collected using...