A5101579110- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Robot Manipulation and Learning
- Coronary Interventions and Diagnostics
- Robotics and Automated Systems
- MRI in cancer diagnosis
- Inflammasome and immune disorders
- Acute Myocardial Infarction Research
- Advanced Manufacturing and Logistics Optimization
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced MRI Techniques and Applications
- Immune cells in cancer
- Esophageal Cancer Research and Treatment
- Neural dynamics and brain function
- Genetic factors in colorectal cancer
- Cardiac Health and Mental Health
- Endometrial and Cervical Cancer Treatments
- Cardiac Structural Anomalies and Repair
- Vascular Procedures and Complications
- Functional Brain Connectivity Studies
- Cardiac Valve Diseases and Treatments
- Polyomavirus and related diseases
- Urban Heat Island Mitigation
- Mechanical Circulatory Support Devices
- Hematopoietic Stem Cell Transplantation
Soochow University
2024
University of Science and Technology Beijing
2024
Guangxi Medical University
2022-2024
Sichuan Cancer Hospital
2021-2023
TEDA International Cardiovascular Hospital
2015-2023
China Tobacco
2023
Suzhou Municipal Hospital
2023
Nanjing Medical University
2023
University of Electronic Science and Technology of China
2021-2022
First Affiliated Hospital of GuangXi Medical University
2022
The immunosuppressive microenvironment of cervical cancer significantly hampers the effectiveness immunotherapy. Herein, PEGylated manganese-doped calcium sulfide nanoparticles (MCSP) were developed to effectively enhance antitumor immune response through gas-amplified metalloimmunotherapy with dual activation pyroptosis and STING pathway. bioactive MCSP exhibited ability rapidly release Ca2+, Mn2+, H2S in tumor microenvironment. disrupted buffer system cells by interfering oxidative...
Immunotherapy has emerged as a potential approach for breast cancer treatment. However, the rigid stromal microenvironment and low immunogenicity of tumors strongly reduce sensitivity to immunotherapy. To sensitize patients immunotherapy, hyaluronic acid-modified zinc peroxide–iron nanocomposites (Fe-ZnO2@HA, abbreviated FZOH) were synthesized remodel increase tumor immunogenicity. The constructed FZOH spontaneously generated highly oxidative hydroxyl radicals (·OH) that degrade acid (HA) in...
Passive thermoelectric devices that utilize radiative cooling and solar heating have witnessed significant advancements in power generation. However, their applications promotions are limited due to the low unsustainable output. In this study, we propose a compact passive device (TED) consisting of generator (TEG) equipped with cooler (RCer) absorber (SAer) for 24-h electricity The RCer is made high-scattering porous cellulose film thickness 100 μm. It coated onto TEG's sky-facing terminal...
Iron metabolism has emerged as a promising target for cancer therapy; however, the innate metabolic compensatory capacity of cells significantly limits effectiveness iron therapy. Herein, bioactive gallium sulfide nanodots (GaS
Objective. The purpose of this study was to investigate the characteristics different frequency bands in spontaneous brain activity among patients with acute basal ganglia ischemic stroke (BGIS). Methods. In present study, thirty-four BGIS and forty-four healthy controls were examined by resting-state functional magnetic resonance imaging (rs-fMRI) from May 2019 December 2020. Two amplitude methods including low-frequency fluctuations (ALFF) fractional ALFF (fALFF) calculated three...
Immunotherapy holds significant promise for cancer treatment. However, the highly immunosuppressive nature of solid tumors limits its effectiveness. Herein, we developed bioactive zinc–nickel hydroxide (ZnNi(OH)4) nanosheets (NSs) that can effectively initiate paraptosis–pyroptosis positive feedback cycle through synergistic ionic effect, thereby mitigating immunosuppression and enhancing efficacy immunotherapy. The acid-sensitive ZnNi(OH)4 NSs releases Ni2+ Zn2+ in weakly acidic tumor...
Background Compared to other subtypes, the CMS4 subtype is associated with lacking of effective treatments and poorer survival rates. Methods A total 24 patients CRC were included in this study. DNA RNA sequencing performed acquire somatic mutations gene expression, respectively. MATH was used quantify intratumoral heterogeneity. PPI analyses identify hub DEGs. Reactome KEGG analyze pathways mutated or Single-sample set enrichment analysis Xcell categorize infiltration immune cells. Results...
Introduction: Total brachial plexus injury not only significantly affects the motor and sensory function of affected upper limbs but also causes further physical mental damage to patients with long-term intractable pain. Previous studies mainly focused on surgical treatment, while a few paid attention neuropathic pain caused by this injury. Changes in volume gray matter brain are thought be associated chronic Methods: Voxel-based morphometry analysis was used compare difference cerebral...
Cervical cancer (CC) is the second most common in women worldwide. Diffusion-weighted imaging (DWI) plays an important role diagnosis of CC, but conventional techniques are affected by many factors.To compare reduced-field-of-view (r-FOV) and full-field-of-view (f-FOV) DWI CC.Preoperative magnetic resonance (MRI) with r-FOV f-FOV images were collected. Two radiologists reviewed using a subjective 4-point scale for anatomical features, susceptibility artifacts, visual distortion, overall...
Abstract Background Limited data were available on the current trends in optimal medical therapy (OMT) after PCI and its influence clinical outcomes China. We aimed to evaluate utilization impact of OMT main adverse cardiovascular cerebrovascular events (MACCEs) post-PCI patients analyzed factors predictive discharge. Methods collected from 3812 individuals 2016.10 2017.09 at TEDA International Cardiovascular Hospital. They classified into an group a non-OMT according their status, which was...
Abstract To investigate the value of star-VIBE sequence in dynamic contrast-enhanced magnetic resonance imaging esophageal carcinoma under free breathing conditions. From February 2019 to June 2020, 60 patients with were prospectively enrolled undergo (DCE-MRI) K-space golden-angle radial stack-of-star acquisition scheme (star-VIBE) (Group A) or conventional 3D volumetric-interpolated breath-hold examination (3D-VIBE) B), completely randomized grouping. The image quality DCE-MRI was...
Objective: To investigate the application status of optimal medical therapy (OMT) in patients with coronary heart disease after percutaneous intervention (PCI) and its influence on 1-year prognosis surgery. Methods: Data 3 812 diagnosed by angiography successfully completed PCI Department Cardiology, TEDA International Cardiovascular Hospital from October 2016 to September 2017 were prospectively collected. The OMT occurrence major adverse cardiovascular cerebrovascular events (MACCE) during...
Background: Left ventricular assist device (LVAD) is considered either a destination therapy for patients with end-stage heart failure or transplantation bridging. LVAD implantation often causes aortic insufficiency (AI), which requires valve repair. However, severe acute AI does not respond well to medication, and re-operation means higher risk the patients; most effective therapeutic strategies LVAD-induced still need further exploration. In this report, we present first described case of...
Objective: High blood pressure (BP) promotes the development of hypertensive target organ damage (TOD). As BP goal 130/80 mmHg is now under debated, whether thresholds and 140/90 differs in patterns TOD remains unclear. This analysis focusing on relationships between different groups TOD. Design method: nested Northern Shanghai Study (NSS, Clinicaltrials.gov NCT02368938), participants prospectively recruited from June 2014 to 2017 [n = 2098, 45.52% men, aged 71.3 ± 6.1 years]. Preclinical...