Hao Liu

ORCID: 0000-0003-3028-1432
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About
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Research Areas
  • Genetic Mapping and Diversity in Plants and Animals
  • Catalytic C–H Functionalization Methods
  • Fusion materials and technologies
  • Nuclear Materials and Properties
  • High-Temperature Coating Behaviors
  • Nuclear reactor physics and engineering
  • Advanced materials and composites
  • Adaptive Control of Nonlinear Systems
  • Asymmetric Synthesis and Catalysis
  • Asymmetric Hydrogenation and Catalysis
  • Click Chemistry and Applications
  • Synthesis of Indole Derivatives
  • Elasticity and Wave Propagation
  • Power Transformer Diagnostics and Insulation
  • Catalytic Cross-Coupling Reactions
  • Laser-Ablation Synthesis of Nanoparticles
  • Hydrogen's biological and therapeutic effects
  • Collagen: Extraction and Characterization
  • Power Quality and Harmonics
  • Dental Anxiety and Anesthesia Techniques
  • Surface Roughness and Optical Measurements
  • High Entropy Alloys Studies
  • Cell death mechanisms and regulation
  • Music Therapy and Health
  • Quinazolinone synthesis and applications

Sichuan University
2011-2024

Stomatological Hospital of Chongqing Medical University
2023-2024

Chongqing Medical University
2023-2024

The Affiliated Yongchuan Hospital of Chongqing Medical University
2023

Sichuan Normal University
2023

Shenyang Aerospace University
2021

Chengdu University of Information Technology
2019

Chengdu University
2016

State Key Laboratory of Biotherapy
2013

Same reactants, different products: Either the Michael addition or [3+2] dipolar cycloaddition products from a one-pot, three-component reaction of aldehydes, diethyl α-aminomalonate and nitroalkenes are selectively obtained in high enantioselectivities, catalyzed by bifunctional urea–tertiary amine monothiourea compound, respectively (see scheme, Ar=3,5-(CF3)2C6H3, Ar1=3,5-F2C6H3).

10.1002/chem.200801410 article EN Chemistry - A European Journal 2008-10-02

In the present study, hypothesis that quercetin liposomes are able to effectively protect against radiation‑induced pulmonary injury in a murine model was tested. C57BL/6J mice receiving whole‑thorax radiotherapy (16 Gy) were randomly divided into three groups: control, radiation therapy plus saline (RT+NS) and RT (RT+QU). At 1, 4, 8 24 weeks post‑irradiation, lung assessed by measuring oxidative damage extent of acute pneumonitis late fibrosis. tissues from RT+NS group, malondialdehyde...

10.3892/ol.2013.1365 article EN Oncology Letters 2013-05-29

An effective strategy to synthesize spirocyclic compounds, [imidazole-4,1'-indene], has been efficaciously developed relied on Rh(III)-catalyzed [3 + 2] spirocyclization of 2H-imidazoles and 1,3-diynes with excellent chemselectivity regioselectivity. This protocol shows a straightforward way construct the versatile compounds wide functional group compatibility, high atom economy, diverse functionalization products.

10.1021/acs.orglett.0c02805 article EN Organic Letters 2020-09-23

Abstract While associations between periodontitis and an elevated risk of cancer have been suggested, the results existing observational studies inconsistent, also leaving room for further investigation into underlying mechanisms. This study was designed to delve possible causal link 20 standard cancers while concurrently identifying potential mediators. We initiated a Mendelian randomization analysis that drew from either publicly accessible or personally obtained genome-wide association...

10.1038/s41598-024-63447-4 article EN cc-by Scientific Reports 2024-05-31

(-)-Renieramycin T, an interesting tetrahydroisoquinolinequinone alkaloid with a novel renieramycin-ecteinascidin mixed framework, is synthesized from the known phenol 16 in 22 steps 6.2% overall yield. In convergent route, key cyclocondensation between isoquinoline moiety 27 and trisubstituted phenylalaninol 14 achieved good selectivity to furnish bistetrahydroisoquinoline 29, which permits rapid construction of pentacyclic framework having fully substituted aromatic A ring.

10.1039/c6ob01064d article EN Organic & Biomolecular Chemistry 2016-01-01

To investigate the therapeutic role of a novel telomere-directed inhibitor, 6-thio-2'-deoxyguanosine (THIO) in gliomas both vitro and vivo.A panel human mouse glioma cell lines was used to test efficacy THIO using viability assays, flow cytometric analyses, immunofluorescence. Integrated analyses RNA sequencing reverse-phase protein array data revealed potential antitumor mechanisms THIO. Four patient-derived xenografts (PDX), two organoids (PDO), were further THIO.THIO effective majority...

10.1158/1078-0432.ccr-21-0374 article EN Clinical Cancer Research 2021-09-30

An efficient and straightforward approach for the synthesis of C7 site-selective BINOL derivatives has been achieved via cost-effective Co(III)-catalyzed C-H cascade alkenylation/intramolecular Friedel-Crafts alkylation units propargyl cycloalkanols. Under advantage pyrazole directing group, protocol allows rapid various BINOL-tethered spiro[cyclobutane-1,1'-indenes].

10.1021/acs.joc.3c00537 article EN The Journal of Organic Chemistry 2023-04-03

In this paper, aiming at the problem of control and obstacle avoidance in quadrotor formation when mathematical modeling is not accurate, artificial potential field method with virtual force used to plan path solve that may fall into local optimal. The adaptive predefined-time sliding mode algorithm based on RBF neural networks enables track planned trajectory a predetermined time also adaptively estimates unknown interference model improve performance. Through theoretical derivation...

10.3390/s23052392 article EN cc-by Sensors 2023-02-21

Seven FeCrAlY-Al2O3 nanoceramic composite coatings are deposited on F/M steel via plasma spraying and laser remelting. A systematic investigation is conducted to examine the dependence of microstructure, mechanical properties, lead–bismuth eutectic (LBE) corrosion resistance nano-Al2O3 addition different Cr Al contents. With increase in content FeCrAlY, gradual refinement coating grains occurs. The promotes elemental segregation precipitation second phase. notably enhances properties that...

10.3390/coatings14040393 article EN Coatings 2024-03-27

Abstract Bating pelt with protease is an important process, which removes unwanted non-collagenous proteins from the and moderately disperse hide collagen network. However, grain surface, may be excessively hydrolyzed during bating due to longer retention time of in than middle layer caused by low mass transfer rate pelt. Here, effects dosage, common auxiliaries molecular weight on were investigated so that we can find key points avoid excessive damage, particularly grain. Observably,...

10.1186/s42825-019-0007-7 article EN cc-by Journal of Leather Science and Engineering 2019-07-29

Nucleos(t)ide analogues (NAs) are currently the most important anti‑viral treatment option for patients with chronic hepatitis B (CHB). Adefovir dipivoxil (ADV), a diester pro‑drug of adefovir, has been widely used clinical therapy virus infection. It previously reported that adefovir induced chromosomal aberrations (CAs) in vitro human peripheral blood lymphocyte assay, while genotoxic mechanism remains elusive. To evaluate possible mechanisms, effects ADV on TK6 and DT40 cell lines, as...

10.3892/ijmm.2019.4164 article EN International Journal of Molecular Medicine 2019-04-11

Abstract In order to study the effect of load on transformer vibration noise. this paper, a S13-M-200/10 distribution is taken as experimental subject and an platform was built collect noise signals under no-load, short-circuit, resistive load, inductive different rate. These are used characteristics transformers rate characteristics. The results show that amplitude 100Hz fundamental frequency increases with increase rate, other basically has no change. will cause 150Hz 250Hz components,...

10.1088/1757-899x/486/1/012033 article EN IOP Conference Series Materials Science and Engineering 2019-06-01

Abstract An efficient rhodium(III)‐catalyzed site‐selective functionalization of 4‐anilinoquinazolines offers exciting possibilities for fused polycyclic 4‐anilinoquinazoline derivatives and N ‐quinazoline‐indoles by using diazo compounds as the elegant coupling partners. This one‐pot cascade approach to establish various complex units with potential biological activities only depends on substrates additives. magnified image

10.1002/adsc.202000895 article EN Advanced Synthesis & Catalysis 2020-10-29
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