A5101936898- Prostate Cancer Treatment and Research
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Urological Disorders and Treatments
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Heat shock proteins research
- Testicular diseases and treatments
- Pelvic floor disorders treatments
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Hormonal Regulation and Hypertension
- Toxin Mechanisms and Immunotoxins
- Genetic and Kidney Cyst Diseases
- Health and Wellbeing Research
- Inflammatory Biomarkers in Disease Prognosis
Fujian Medical University
2017-2024
First Affiliated Hospital of Fujian Medical University
2017-2024
Purpose: To investigate the risk factors for progression to castration-resistant prostate cancer (CRPC) in metastatic (mPCa) patients who underwent androgen deprivation therapy (ADT). Methods: We analyzed 216 with mPCa ADT between January 2006 and December 2015 at First Affiliated Hospital of Fujian Medical University. Univariate multivariate Cox regression analysis were used explore CRPC. Kaplan-Meier log-rank test evaluate difference progression-free survival (PFS). Results: A total 121...
Abstract Testicular cancer is the most common solid malignancy among young men. We downloaded data of testicular patients from The Cancer Genome Atlas database to find novel genes in microenviroment based on ESTIMATE algorithm‐derived immune scores. A total 156 cases were included this study and 165 normal tissues used. divided into high‐ low‐score groups their identified 1,226 differentially expressed (fold change > 2, false discovery rate < 0.05), including 688 downregulated 538...
Bladder cancer (BCa) is one of the important tumors that have been proven to be treatable with immunotherapy. This study aims identify and validate a molecular prognostic index BCa based on immunogenomic landscape analysis.The genome atlas (TCGA) database immunology analysis portal (ImmPort) were used identified differentially expressed immune-related genes (IRGs). Prognostic IRGs screened protein-protein interaction (PPI) network was constructed. Multivariate Cox performed develop BCa....
Objective:The purpose of this study was to evaluate the efficacy and feasibility R.E.N.A.L. Nephrometry Score postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods:The included 288 patients diagnosed with ccRCC who had complete CT/CTA data Scores underwent surgery at our center between January 2012 December 2015.The relationship pathological grade masses evaluated.Results: Univariate analysis indicated that diagnostic modality, cystic necrosis, enlargement regional...
Abstract Lymph node metastasis is one of the most important independent risk factors that can negatively affect prognosis prostate cancer (PCa); however, exact mechanisms have not been well studied. This study aims to better understand underlying mechanism lymph in PCa by bioinformatics analysis. We analysed a total 367 cases from genome atlas database and performed weighted gene co‐expression network analysis explore some modules related metastasis. Gene Ontology pathway enrichment were...
M2-tumor-associated macrophages (TAMs) work as a promoter in the processes of bone metastases, chemotherapy resistance, and castration resistance prostate cancer (PCa), but how M2-TAMs affect PCa has not been fully understood. In this study, we analyzed proportion tumor-infiltrating immune cells using CIBERSORT algorithm, based on samples from Cancer Genome Atlas database. Then performed weighted gene co-expression network analysis to examine modules concerning infiltrated M2-TAMs. Gene...
Abstract Expression of kinesin family member 18B (KIF18B), an ATPase with key roles in cell division, is deregulated many cancers, but its involvement prostate cancer (PCa) unclear. Here, we investigated the expression and function KIF18B human PCa specimens lines using bioinformatics analyses, immunohistochemical immunofluorescence microscopy, RT-qPCR western blot analyses. was overexpressed compared paracancerous tissues associated poorer disease-free survival. In vitro, knockdown promoted...
Patients with brain metastases (BM) from renal cell carcinoma (RCC) were considered to experience a poor prognosis. However, there is little knowledge on the risk factors for BM RCC at diagnosis. This study was aimed exploring patients and interaction among these factors.A total of 38759 cases identified Surveillance, Epidemiology, End Results (SEER) database. Risk evaluated by univariate multivariate logistic regression analyses. Interaction effect between age tumor size tested.There...
Background: Numerous patients with clear cell renal carcinoma (ccRCC) experience drug resistance after immunotherapy.Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response.Purpose: We performed bioinformatics analysis to better understand the role of Treg in ccRCC.Results: Module 10 revealed most relevance cells.Functional annotation showed that biological processes and pathways were mainly related activation system immunoreaction.Four hub genes selected: LCK,...
This study was to explore the risk factors for postoperative bladder neck contracture (BNC) after transurethral operation of prostate in patients with small-volume prostatic obstruction.Clinicopathologic data at our center from February 2016 January 2020 were retrospectively collected and analyzed. Clinicopathological characteristics between without BNC compared. Multivariate logistic regression used determine BNC.There a total 39 (8.53%) BNC. analysis demonstrated that preoperative diameter...
Objective: To explore the correlations among alternative splicing (AS), factors (SF) and survival outcome in adrenocortical carcinoma (ACC) patients.Results: A total of 92 ACC patients were included.Univariate analysis identified 3919 AS events significantly associated with overall survival.Lasso method followed by multivariate revealed that prognostic capacity these survival-related is satisfactory.Interestingly, we found area under curve (AUC) AA, AD, AP RI more than 0.9, indicating four...
To explore the risk factors for postoperatively pathological lymph node metastasis in patients with clinical T2N0M0 stage prostate cancer (PCa).We retrospectively analyzed clinicopathological data of 316 T2 PCa and preoperative negative nodes [LN(-)] indicated by imaging (cT2N0M0) between January 2014 May 2019. Multivariate logistic regression analysis was performed to determine pLN(+) cT2N0M0 PCa. Spearman correlation used relationship tumor burden Prostate Imaging Reporting Data System...
Background: Seminoma accounts for the most part of cases testicular germ cell tumor, which is common malignancy among males between ages 15 and 44 years. Understanding molecular mechanism tumorigenesis important better clinical diagnosis treatment. Purpose: We performed bioinformatics analysis to understand seminoma at genetic level explore potential candidate genes or molecules diagnosis, treatment, prognosis. Methods: A gene expression profile (GSE8607), containing 40 samples three healthy...
This study aimed to identify potential biomarkers for prostate cancer (PCa) progression and metastasis, discern their biological functions.Bioinformatics methods were used screen hub genes. The expression level of key genes in PCa was determined prognostic significance examined. A series functional assays performed investigate the function highest-ranking gene.Actin related protein 2/3 complex subunit 1A (ARPC1A) identified as gene. ARPC1A highly expressed tissues cell lines, an independent...
Urethral stricture is a clinical challenge for both patients and clinicians. Post-traumatic urethral associated with formation of scar tissue caused by excessive inflammation. The aim this study exploring potential therapeutic strategies condition.In vivo experiments on New Zealand rabbits in vitro THP-1 monocytes fibroblasts were performed to investigate the effects post-traumatic exosomes isolated from IL-1β-treated mesenchymal stem cells (Exo-MSCsIL-1β) role macrophage M2 polarization...
Abstract Objective To explore the influence of postoperative body mass index (BMI) change on quality life (QOL) in patients undergoing radical cystectomy (RC) plus modified single stoma cutaneous ureterostomy (MSSCU) or ileal conduit (IC). Methods Patients were divided into two groups according to different BMI patterns: experiencing an elevated level, along with a clinically significant increase their (an more than 10%) categorized as Group 1, while decrease reduction (a 5%) 2. Spearman...
Objective To explore whether preoperative 18Fluorine-Fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) in combination with neutrophil–lymphocyte ratio (NLR) could accurately predict malignant lesions of upper urinary tract (UUT). Methods and Materials The clinicopathologic data a total 252 patients UUT receiving surgical treatment at our center from January 2012 to November 2019 were retrospectively analyzed. All performed routine hematological examination,...
Emerging evidence indicates that long noncoding RNA (lncRNA) plays an important biological role in clear cell renal carcinoma (ccRCC); however, the clinical value of tumor mutation burden-related lncRNA ccRCC patients is unknown yet.