A5101983658- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Endoplasmic Reticulum Stress and Disease
- Respiratory Support and Mechanisms
- Inflammation biomarkers and pathways
- Advanced Glycation End Products research
- Therapeutic Uses of Natural Elements
- Acute Ischemic Stroke Management
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Metabolism, Diabetes, and Cancer
- Functional Brain Connectivity Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- RNA modifications and cancer
- Immune cells in cancer
- Tracheal and airway disorders
- Nosocomial Infections in ICU
- Mental Health Research Topics
- Circular RNAs in diseases
- Schizophrenia research and treatment
- Airway Management and Intubation Techniques
- Machine Learning in Healthcare
- Genomics and Phylogenetic Studies
University of Science and Technology of China
2019-2025
Anhui Mental Health Center
2024-2025
First Affiliated Hospital of Henan University of Science and Technology
2025
Wannan Medical College
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2018-2024
Anhui Provincial Hospital
2018-2020
Shanghai Tenth People's Hospital
2017
Nanjing Medical University
2016
Jiangsu Province Hospital
2016
Glycyrrhetinic acid (GA) is a natural compound extracted from liquorice, which often used in traditional Chinese medicine. The purpose of the present study was to investigate antitumor effect GA human non‑small cell lung cancer (NSCLC), and its underlying mechanisms vitro. We have shown that suppressed proliferation A549 NCI‑H460 cells. Flow cytometric analysis showed arrested cycle G0/G1 phase without inducing apoptosis. Western blot indicated mediated G1‑phase arrest by upregulation...
To explore the applicability of metagenomic next-generation sequencing (mNGS) technology for detection blood pathogens in intensive care unit patients.The clinical data 63 critically ill patients who could not be diagnosed with culture (BC) and underwent mNGS sample testing were retrospectively analyzed. The diagnostic efficacy was compared that traditional methods; distribution identified by analyzed; differences laboratory tests, comorbidities, treatment, prognosis between mNGS-positive...
An increased risk of colorectal cancer is related to the development metabolic syndromes including hyperglycemia, and hyperinsulinemia. The high circulatory levels glucose and/or insulin or application exogenous may promote carcinogenesis, progression metastasis, which can be attributed Warburg effect aerobic glycolysis. We attempted resolve these existing questions by applying analog 2-deoxyglucose (2DG). According in vitro studies we performed, glycolysis cells could interrupted 2DG as it...
<title>Abstract</title> <bold>Background:</bold> Sepsis-induced acute kidney injury (SA-AKI) significantly increases mortality and healthcare burdens. Identifying key risk factors is crucial for improving patient outcomes. <bold>Objectives:</bold> This study aims to identify the primary affecting in SA-AKI patients using MIMIC-III database. <bold>Methods:</bold> A retrospective analysis was conducted on 4,868 from Clinical data first 24 hours of ICU admission were analyzed logistic...
This work aims to investigate the function and mechanism of long non‐coding RNA (lncRNA) cytoskeleton regulator (CYTOR) in myocardial injury induced by sepsis. The sepsis‐induced model mice was established intraperitoneal injection LPS (10 mg/kg) vivo, cardiomyocyte H9c2 treated with mimic sepsis vitro. CYTOR expression miR‐24 were detected qRT‐PCR. After up‐regulation or down‐regulation cells, viability cells via MTT assay, cell apoptosis TUNEL assay. Western blot applied determine level...
High mobility group box 1 (HMGB1) can promote the migration of macrophages and release inflammatory cytokines, functions associated with occurrence sepsis. The role microRNA (miR)‑25 in targeted regulation HMGB1 expression macrophage cytokines remains uncharacterized. present study investigated association between miR‑25, sepsis by analyzing miR‑25 patients also whether serves a targeting factor release. Patients were selected from Intensive Care Unit, serum levels HMGB1. peripheral blood...
Osteosarcoma (OS) is an aggressive bone malignancy that affects rapidly growing bones and associated with a poor prognosis. Our previous study showed cytochrome c1 (CYC1), subunit of the bc1 complex (complex III) mitochondrial electron chain, overexpressed in human OS tissues cell lines its silencing induces apoptosis vitro inhibits tumor growth vivo. Here, we investigated mechanism underlying modulation CYC1 expression role resistance to apoptosis.qRT-PCR, luciferase reporter assay, western...
To evaluate the diagnostic value and clinical application of metagenomic next-generation sequencing (mNGS) for infections in critically ill patients.Comparison performance mNGS conventional microbiological testing pathogens was analyzed 234 patients. The differences between immunocompetent immunocompromised individuals mNGS-guided anti-infective treatment adjustment were also analyzed.The sensitivity specificity bacterial fungal detection 96.6% (95% confidence interval [CI], 93.5%-99.6%)...
Background Patients with chronic critical illness (CCI) experience poor prognoses and incur high medical costs. However, there is currently limited clinical awareness of sepsis-associated CCI, resulting in insufficient vigilance. Therefore, it necessary to build a machine learning model that can predict whether sepsis patients will develop CCI. Methods Clinical data on 19,077 from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database were analyzed. Predictive factors...
To investigate the effect of early rehabilitation physiotherapy on muscle quality and function in critical patients.A prospective randomized controlled study was performed. Adult critically ill patients admitted to intensive care unit (ICU) Anhui Provincial Hospital from October 1st, 2016 August 31st, 2017 who had been hospitalized for more than 7 days acute physiology chronic health evaluation II (APACHE II) > 8 were enrolled, they divided into treatment group control according random...
To estimate the incidence and risk factors for deep venous thrombosis (DVT) in patients with severe traumatic brain injury (TBI) treated intensive care unit (ICU).105 TBI admitted to First Affiliated Hospital of University Science Technology China from January 2016 June 2018 were enrolled [Glasgow coma scale (GCS) 3-8; concise score other parts ≤ 3]. All did not receive any medication or physical measures prevent DVT during hospitalization. Bilateral compression Doppler ultrasounds double...