A5024822266- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Infective Endocarditis Diagnosis and Management
- Cytomegalovirus and herpesvirus research
- Infectious Diseases and Mycology
- Central Venous Catheters and Hemodialysis
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Viral-associated cancers and disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Herpesvirus Infections and Treatments
- Polyomavirus and related diseases
- Antibiotics Pharmacokinetics and Efficacy
- Infections and bacterial resistance
- Hematopoietic Stem Cell Transplantation
- Fungal Biology and Applications
- Plant Pathogens and Fungal Diseases
- Chronic Lymphocytic Leukemia Research
- Tuberculosis Research and Epidemiology
- Actinomycetales infections and treatment
The University of Texas MD Anderson Cancer Center
2015-2024
Baylor College of Medicine
2014
Dana-Farber Brigham Cancer Center
2014
Brigham and Women's Hospital
2014
Harvard University
2014
Dana-Farber Cancer Institute
2014
University of Houston
2001-2008
Shri Jagdishprasad Jhabarmal Tibrewala University
2006
Texas Tech University
2004
Washington University in St. Louis
1988-1989
Sixty-one strains of the root-associated nitrogen fixer Spirillum lipoferum exhibited a similar morphology in peptone--succinate salts medium: vibrioid cells having diameter 1.0 micrometer. When grown broth had single polar flagellum, but when on agar at 30 degrees C lateral flagella shorter wavelength were also formed. The DNA base composition was 69--71 mol% guanine + cytosine determined by thermal denaturation. homology experiments indicated occurrence two distinct related groups: 46...
Community respiratory viruses (CRVs) have been recognized as a potential cause of pneumonia and death among hematopoietic stem cell transplantation (HSCT) recipients patients with hematologic malignancies. We reviewed the Microbiology Laboratory records dated from July 1, 2000, to June 30, 2002, identify who had specimens positive for influenza, parainfluenza, syncytial virus, or picornavirus. identified 343 infections underlying malignancies HSCT. collected data on type disease, age, sex,...
The incidence, epidemiology, Candida species distribution, resistance patterns, and outcome of candidemia in high-risk hematologic malignancy and/or stem cell transplantation patients have not been extensively described since the introduction new antifungal agents.In this retrospective study, authors reviewed medical records microbiologic data with at University Texas M. D. Anderson Cancer Center from March 2001 to February 2007.The analyzed 173 episodes (170 patients), 125 (72%) which were...
Autopsy studies remain an essential tool for understanding the patterns of fungal disease not detected ante mortem with current diagnostic approaches. We collected data concerning microbiological trends, patient clinical characteristics and sites involvement invasive infections (IFIs) identified at autopsy in a single large cancer treatment centre over 20-year period (1989-2008). The rate IFI prevalence both declined significantly during study period. Aspergillus spp. decreased from first 15...
Catheter-related bloodstream infections are associated with recognized morbidity and mortality, especially in critically ill patients. Accurate diagnosis of such results proper management patients reducing unnecessary removal catheters.To evaluate differential time to positivity as a method for diagnosing catheter-related bacteremias caused by both short-term long-term use central venous catheters.Prospective study design.M.D. Anderson Cancer Center, Houston, Texas, tertiary care cancer...
From 1 November 1992 through May 1993 and from 1994, we conducted a prospective surveillance study at the University of Texas M.D. Anderson Cancer Center (Houston) to evaluate role community respiratory virus infections in hospitalized adult bone marrow transplant (BMT)recipients. Respiratory secretions were obtained all BMT recipients with acute illnesses.During these two winters, was isolated 37 (36%)of 102 patients 30 (26%)of 115 patients, respectively. Approximately half (49%) due...
Pseudomonas aeruginosa bacteremia is a serious and possibly fatal condition in patients with cancer.To ascertain the frequency, demographics, predisposing factors for P. cancer to determine efficacy of various therapeutic regimens.Patient records Clinical Microbiology Laboratory, The University Texas, M. D. Anderson Cancer Center, Houston, were reviewed. From January 1, 1991, through December 31, 1995, 245 eligible cases identified. We examined patient underlying malignant neoplasm its...
We correlated results of microbiologic culture and histopathologic examination for 2,891 consecutive samples from autopsy tissue, surgical or biopsy bronchoalveolar lavage (BAL) bronchial washing (BW) specimens. For 23 cases with suspected invasive septate mold infections by examination, yielded a in 12 (52%). 1,683 samples, evidence infection was present 30 9 which also grew (30%); 20 additional alone, possibly representing contamination. Of 1,185 BAL BW evident 28 cytologic culture, 68...
A modified oxidase reagent, 1% tetramethyl-p-phenylenediamine in dimethyl sulfoxide, proved superior to the routinely used aqueous dihydrochloride detecting weakly oxidase-positive gram-negative bacteria after 24 h of growth on agar media (40 40 positive versus 22 positive). The bacterial inoculum was obtained with a cotton-tipped swab instead loop or wooden applicator, and reaction required less than 15 s.
Hemorrhagic cystitis is a common cause of morbidity after allogeneic stem cell transplantation, frequently associated with BK virus infection. We hypothesized that patients positive viruria before unrelated or mismatched related donor hematopoietic transplantation have higher incidence hemorrhagic cystitis.To test this hypothesis, we prospectively studied 209 (median age 49 years, range 19-71) hematologic malignancies who received bone marrow (n=78), peripheral blood (n=108) umbilical cord...
Abstract Cancer patients are at risk for candidemia, and increasing Candida spp. resistance poses an emerging threat. We determined rates of antifungal drug resistance, identified factors associated with investigated the correlation between all-cause mortality among cancer ≥1 C. glabrata–positive blood culture MD Anderson Center, Houston, Texas, USA, during March 2005–September 2013. Of 146 isolates, 30 (20.5%) were resistant to fluconazole, 15 (10.3%) caspofungin, 10 (6.8%) multiple drugs...
Section:ChooseTop of pageAbstract <<OverviewIntroductionWorkshop Format and Metho...Defining ICHPICH PopulationsConsensus DefinitionDefining Diagnostic Crite...Current Approa...ConclusionsReferences
To determine the impact of catheter management on acute and long-term outcome catheter-related coagulase-negative staphylococcal bacteremia.Retrospective surveillance sepsis using quantitative blood cultures.University-affiliated tertiary cancer center.Seventy patients with bacteremia were studied by retrospective chart review. The clinical characteristics bacteremias determined. immunosuppressive risk factors, antibiotic therapy, recurrence was investigated.Acute sepsis-related morbidity...
To assess the spectrum and outcome of trichosporonosis (TS) in cancer patients, we reviewed medical records 17 such patients with TS. TS presented most commonly as fungemia (n=10, including 7 central-venous-catheter–related infection) either pulmonary or soft tissue infection (n=3, each). Most (65%) had acute leukemia, 11 neutropenia, 9 (53%) received high doses corticosteroids. 10 breakthrough during therapy at least 1 following: amphotericin B, fluconazole, itraconazole, voriconazole. The...
Abstract Objective: To study the characteristics of catheter-related, gram-negative bacteremia (GNB) and role central venous catheter (CVC) removal. Design: This retrospective involved a search microbiological department records CVC blood cultures patients' medical records. Setting: University Texas M. D. Anderson Cancer Center, tertiary-care hospital in Houston, Texas. Patients: Patients with cancer who had catheter-related GNB, defined as (1) positive tip culture at least 15 colony-forming...
Many uncommon Candida species that cause bloodstream infections (BSIs) are not well-characterized. We investigated the epidemiology, antifungal use, susceptibility patterns, and factors associated with all-cause death among cancer patients in whom spp. BSIs were diagnosed at a treatment center during January 1998–September 2013. Of 1,395 isolates, 79 from 68 The incidence density of their proportion to all candidemia episodes substantively increased study period, rise was increasing use...
Rapidly growing mycobacteria (RGM) are environmental organisms capable of causing a wide spectrum diseases. We identified 116 cancer patients with RGM. Mycobacterium mucogenicum was the leading cause disease. Removal catheter correlated significant decrease in bacteremia relapse rate (P = .007). A median duration 4 weeks therapy produced good outcome.
Resistance to the novel β-lactam/β-lactamase inhibitor combination ceftazidime-avibactam (CAZ-AVI) among carbapenem-resistant Enterobacteriaceae (CRE) has infrequently been reported in United States. We report unexpectedly high rates of resistance CAZ-AVI CRE bloodstream isolates at our institution associated with nonoutbreak spread New Delhi metallo-β-lactamase diverse species.
Anecdotal clinical reports suggested a benefit of adjunct immune checkpoint inhibitors (ICIs) to treat invasive mucormycosis. However, proof-of-concept data in animal models and mechanistic insights into the effects ICIs on host defense against Mucorales are lacking. Therefore, we studied PD-1 PD-L1 (4 doses 250 µg/kg) outcomes immunopathology pulmonary mucormycosis (IPM) cyclophosphamide- cortisone acetate-immunosuppressed mice. Rhizopus arrhizus-infected mice receiving either ICI...
We developed a method to identify mycobacteria by sequencing hypervariable regions of the polymerase chain reaction–amplified 16S ribosomal RNA gene. This is nearly specific for and uses positive culture from liquid or solid medium without need lengthy subculture. It shortens identification time 3 days, which much faster than conventional biochemical (mean, 8 weeks). applies all (approximately 100 species), unlike current nucleic acid hybridization methods, probe only 4 species. The...
Nocardiosis (NOC) is an important cause of infection in immunocompromised patients. However, large series patients with cancer have not been described. We review the records and NOC who were evaluated at The University Texas M. D. Anderson Cancer Center, Houston, Texas, between 1988 2001, we describe incidence, microbiologic clinical characteristics, treatment, outcome this population. Forty-two a total 43 episodes identified (incidence 60 cases per 100,000 admissions). Twenty-seven (64%)...