A5062072341- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Adenosine and Purinergic Signaling
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Liver Diseases and Immunity
- Hepatitis C virus research
- Lipid metabolism and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Adolescent and Pediatric Healthcare
- Endoplasmic Reticulum Stress and Disease
- Proteins in Food Systems
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Screening and Detection
- Protein Structure and Dynamics
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Microtubule and mitosis dynamics
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Microencapsulation and Drying Processes
- Liver physiology and pathology
Beth Israel Deaconess Medical Center
2016-2025
Harvard University
2016-2025
Jiangnan University
2025
Northeast Agricultural University
2024-2025
Nanjing Forestry University
2025
Shanghai Academy of Agricultural Sciences
2024
Guilin Medical University
2024
Hadassah Medical Center
2024
Central South University
2020-2023
China Agricultural University
2021-2023
Background and Aims: A new term, metabolic dysfunction–associated steatotic liver disease (MASLD), has been proposed by a multi-society expert panel. However, it remains unclear whether hepatic steatosis per se in MASLD contributes to an increased risk of mortality individuals with any cardio-metabolic factor (CMRF), which is also significant for mortality. This study aimed compare all-cause cause-specific between the “MASLD/MetALD” “no (SLD)” groups CMRF. Approach Results: population-based...
Summary Background Recent animal studies have shown that platelets directly activate hepatic stellate cells to promote liver fibrosis, whereas anti‐platelet agents decrease fibrosis. It is unknown whether platelet inhibition by aspirin prevents fibrosis in humans. Aim To examine the association between use and among adults with suspected chronic disease. Methods We conducted a cross‐sectional analysis using data from National Health Nutrition Examination Survey III . identified 1856...
Abstract The Human BioMolecular Atlas Program (HuBMAP) aims to construct a 3D Reference (HRA) of the healthy adult body. Experts from 20+ consortia collaborate develop Common Coordinate Framework (CCF), knowledge graphs and tools that describe multiscale structure human body (from organs tissues down cells, genes biomarkers) use HRA characterize changes occur with aging, disease other perturbations. v.2.0 covers 4,499 unique anatomical structures, 1,195 cell types 2,089 biomarkers (such as...
Hepatic assembly of triacylglycerol (TAG)-rich very low density lipoproteins (VLDL) is achieved through recruitment bulk TAG (presumably in the form lipid droplets within microsomal lumen) into VLDL precursor containing apolipoprotein (apo) B-100. We determined protein/lipid components lumenal (LLD) cells expressing recombinant human apoC-III (C3wt) or a mutant (K58E, C3KE) initially identified humans that displayed hypotriglyceridemia. Although expression C3wt markedly stimulated secretion...
BackgroundWhole-exome sequencing (WES) is an effective tool for diagnosis in patients who remain undiagnosed despite a comprehensive clinical work-up. While WES being used increasingly pediatrics and oncology, it remains underutilized non-oncological adult medicine, including with liver disease, part based on the faulty premise that adults are unlikely to harbor rare genetic variants large effect size. Here, we aim assess burden of underlying disease at two major tertiary referral academic...
We have shown that expression of apolipoprotein (apo) C-III promotes VLDL secretion from transfected McA-RH7777 cells under lipid-rich conditions. To determine structural elements within apoC-III confer to this function, we contrasted wild-type with a mutant Ala23Thr originally identified in hypotriglyceridemia subjects. Although synthesis [(3)H]glycerol-labeled TAG was comparable between expressing (C3wt cells) or (C3AT cells), [(3)H]TAG C3AT markedly decreased. The lowered associated an...
The aspartate-to-alanine aminotransferase ratio (AAR) is associated with liver fibrosis, but its predictive performance suboptimal. We hypothesized that the association between AAR and disease depends on absolute transaminase levels developed validated a model to predict liver-related outcomes in general population. A Cox regression based age, AAR, alanine (ALT) level (dynamic [dAAR]) using restricted cubic splines was Finnish population-based health-examination surveys (FINRISK, 2002-2012;...
A major challenge in the management of nonalcoholic fatty liver disease (NAFLD) is to identify patients with steatohepatitis (NASH) and early fibrosis. The progression NAFLD accompanied by distinctive changes very low density lipoprotein (VLDL), a particle produced exclusively liver. Herein, we sought determine characteristics VLDL profiles associated NASH fibrosis.We evaluated 128 from single centre registry, examined size, total subclass concentrations relation activity score (NAS),...
Background Dyslipidemia, typically recognized as high serum triglyceride, low-density lipoprotein cholesterol (LDL-C) or low high-density (HDL-C) levels, are associated with nonalcoholic fatty liver disease (NAFLD). However, LDL-C levels could result from defects in metabolism impaired synthetic function, and may serve ab initio markers for unrecognized diseases. Whether such relationships exist the general population has not been investigated. We hypothesized that despite common conception...
Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous driven by genetic and environmental factors. MicroRNAs (miRNAs) serve as pleiotropic post-transcriptional regulators of cellular pathways. Although several miRNAs have been associated with NAFLD fibrosis, there are limited studies in humans examining their differential association pathogenic factors or histological features NAFLD. We examined the relationships five best-described circulating microRNAs (miR-34a, miR-122, miR-191,...
Introduction: Vitamin A, a fat-soluble vitamin that includes retinol and carotenoids, is implicated in liver fibrosis, whereas its deficiency has been associated with various diseases higher overall mortality. This study aims to determine the relationship between levels of A species as well liver-related mortality population US. Methods: total 12,299 participants from National Health Nutrition Examination Survey III (NHANES III) were analyzed provide nationally representative estimates...
Background: Low-density lipoprotein cholesterol (LDL-C) is a well-established risk factor for cardiovascular disease, and it plays causal role in the development of atherosclerosis. Genome-wide association studies (GWASs) have successfully identified hundreds genetic variants associated with LDL-C. Most these loci fall non-coding regions genome, unclear how affect circulating lipid levels. One hypothesis that genetically mediated variation transcript abundance, detected via analysis...