A5028654391- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Nutrition, Health and Food Behavior
- Nutritional Studies and Diet
- Antibiotic Resistance in Bacteria
- Estrogen and related hormone effects
- Protease and Inhibitor Mechanisms
- Vitamin C and Antioxidants Research
- Vitamin K Research Studies
- Ecology and Conservation Studies
- Telomeres, Telomerase, and Senescence
- TGF-β signaling in diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Agriculture, Soil, Plant Science
- Endoplasmic Reticulum Stress and Disease
- Redox biology and oxidative stress
- Pediatric Hepatobiliary Diseases and Treatments
- Engineering Applied Research
- Diverse Topics in Contemporary Research
- Hormonal Regulation and Hypertension
- Food Quality and Safety Studies
Seoul National University
2007-2025
Ulsan University Hospital
2017-2025
University of Ulsan
2017-2025
Ulsan College
2017-2025
Beth Israel Deaconess Medical Center
2016-2021
Korea University
2020-2021
Harvard University
2012-2020
Wonkwang University
2010-2017
Food & Nutrition
2013-2015
Kangbuk Samsung Hospital
2013-2014
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant. Specifically, fails suppress glucose production, yet successfully stimulates de novo lipogenesis. The mechanisms underlying this dysregulation remain controversial. Here, we hypothesized that carbohydrate-responsive element-binding protein (ChREBP), transcriptional activator of glycolytic and lipogenic genes, plays central role paradox....
Transforming growth factor (TGF)-beta has been reported to exert inhibitory activity in normal epithelial cells whereas it induces cell proliferation and invasive phenotypes advanced carcinomas. Our previous study showed that MCF10A, a spontaneously immortalized "normal" breast line, is resistant TGF-beta-induced inhibition, suggesting conversion of TGF-beta signaling into an oncogenic pathway may occur at the early stage tumor development/progression. To address this issue, we investigated...
Increased fructose consumption is a contributor to the burgeoning epidemic of non-alcoholic fatty liver disease (NAFLD). Recent evidence indicates that metabolic hormone FGF21 regulated by in humans and rodents may play functional role this nutritional context. Here, we sought define mechanism which ingestion regulates determine whether contributes an adaptive response consumption. We tested transcription factor carbohydrate responsive-element binding protein (ChREBP) fructose-mediated...
Dynamic changes in cell size are associated with development and pathological conditions, including aging. Although enlargement is a prominent morphological feature of cellular senescence, its functional implications unknown; moreover, how senescent cells maintain their state less understood. Here we show that an extensive remodeling actin cytoskeleton necessary for establishing senescence-associated pro-inflammatory secretory phenotype (SASP). This attributed to balancing act between the...
Increased sugar consumption is a risk factor for the metabolic syndrome including obesity, hypertriglyceridemia, insulin resistance, diabetes, and nonalcoholic fatty liver disease (NAFLD). Carbohydrate responsive element–binding protein (ChREBP) transcription that responds to regulate adaptive programs. Hepatic ChREBP particularly fructose global ChREBP-KO mice are intolerant diets containing fructose. It has recently been suggested protects from hepatotoxicity following high-fructose...
Modification of the outer membrane charge by a polymyxin B (PMB)-induced PmrAB two-component system appears to be dominant phenomenon in PMB-resistant Acinetobacter baumannii. variants and many clinical isolates also appeared produce vesicles (OMVs). Genomic, transcriptomic, proteomic analyses revealed that upregulation pmr operon decreased membrane-linkage proteins (OmpA, OmpW, BamE) are linked overproduction OMVs, which promoted enhanced biofilm formation. The addition OMVs from into...
Abstract Elevated p21ras expression is associated with tumor aggressiveness in breast cancer including the extent of invasion into fat tissues, infiltration lymphatic vessels and recurrence. In present study, we have examined roles H-ras N-ras, members human ras gene family, pathogenesis cancer. We show that H-ras, but not induces an invasive phenotype epithelial cells (MCF10A) as determined by Matrigel assay, whereas both N-ras induce anchorage-independent growth, shown soft agar assay....
Elevated p21ras expression is associated with tumor aggressiveness in breast cancer including the extent of invasion into fat tissues, infiltration lymphatic vessels and recurrence. In present study, we have examined roles H-ras N-ras, members human ras gene family, pathogenesis cancer. We show that H-ras, but not induces an invasive phenotype epithelial cells (MCF10A) as determined by Matrigel assay, whereas both N-ras induce anchorage-independent growth, shown soft agar assay. effects...
A major challenge in the management of nonalcoholic fatty liver disease (NAFLD) is to identify patients with steatohepatitis (NASH) and early fibrosis. The progression NAFLD accompanied by distinctive changes very low density lipoprotein (VLDL), a particle produced exclusively liver. Herein, we sought determine characteristics VLDL profiles associated NASH fibrosis.We evaluated 128 from single centre registry, examined size, total subclass concentrations relation activity score (NAS),...
Patients with both major forms of diabetes would benefit from therapies that increase β-cell mass. Glucose, a natural mitogen, drives adaptive expansion mass by promoting proliferation. We previously demonstrated carbohydrate response element-binding protein (ChREBPα) is required for glucose-stimulated proliferation and overexpression ChREBPα amplifies the proliferative effect glucose. Here we found reprogrammed anabolic metabolism to promote increased mitochondrial biogenesis, oxygen...
Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous driven by genetic and environmental factors. MicroRNAs (miRNAs) serve as pleiotropic post-transcriptional regulators of cellular pathways. Although several miRNAs have been associated with NAFLD fibrosis, there are limited studies in humans examining their differential association pathogenic factors or histological features NAFLD. We examined the relationships five best-described circulating microRNAs (miR-34a, miR-122, miR-191,...
Several reports suggest that obesity is a risk factor for osteoporosis. Vitamin K plays an important role in improving bone metabolism. This study examined the effects of vitamin K1 and K2 supplementation on biochemical markers turnover morphological microstructure bones by using obese mouse model. Four-week-old C57BL/6J male mice were fed 10% fat normal diet group or 45% kcal high-fat group, with without 200 mg/1000 g (Normal + K1, K1) K2, K2) 12 weeks.Serum levels osteocalcin higher than...