Jagpal S. Klair

ORCID: 0000-0003-4345-2851
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About
Contact & Profiles
Research Areas
  • Esophageal and GI Pathology
  • Gastrointestinal disorders and treatments
  • Liver Disease and Transplantation
  • Gallbladder and Bile Duct Disorders
  • Liver Disease Diagnosis and Treatment
  • Pancreatic and Hepatic Oncology Research
  • Dysphagia Assessment and Management
  • Biliary and Gastrointestinal Fistulas
  • Gastric Cancer Management and Outcomes
  • Colorectal Cancer Screening and Detection
  • Gastroesophageal reflux and treatments
  • Organ Transplantation Techniques and Outcomes
  • Pancreatitis Pathology and Treatment
  • Tracheal and airway disorders
  • Pediatric Hepatobiliary Diseases and Treatments
  • Gastrointestinal Tumor Research and Treatment
  • Intraperitoneal and Appendiceal Malignancies
  • Intestinal Malrotation and Obstruction Disorders
  • Intestinal and Peritoneal Adhesions
  • Genetic factors in colorectal cancer
  • Hepatitis C virus research
  • Endometrial and Cervical Cancer Treatments
  • Ovarian cancer diagnosis and treatment
  • Esophageal Cancer Research and Treatment
  • Eosinophilic Esophagitis

Franciscan Health
2022-2025

Bellevue Hospital Center
2023

Virginia Mason Medical Center
2019-2022

Troy Gastroenterology
2022

Kaiser Permanente
2022

University of Iowa Hospitals and Clinics
2016-2020

University of Arkansas for Medical Sciences
2014-2018

University of Iowa
2017

University of Arkansas at Little Rock
2015

Yahoo (United Kingdom)
2015

Objectives: Diagnosing minimal hepatic encephalopathy (MHE) is challenging, and point-of-care tests are needed. Stroop EncephalApp has been validated for MHE diagnosis in single-center studies. The objective of the study was to validate a multicenter study. Methods: Outpatient cirrhotics (with/without prior overt (OHE)) controls from three sites (Virginia (VA), Ohio (OH), Arkansas (AR)) underwent two gold standards, psychometric score (PHES) inhibitory control test (ICT)....

10.1038/ajg.2015.377 article EN The American Journal of Gastroenterology 2015-12-08

Postmenopausal women with nonalcoholic steatohepatitis are at an increased risk of hepatic fibrosis compared premenopausal women. Whether duration estrogen deficiency in postmenopausal state dictates individual's remains uninvestigated. We assessed the associations age menopause and time from severity fatty liver disease. Data 488 (1) histologic diagnosis disease (2) self‐reported information on were analyzed. The premature (age <40 years) study enrollment ‐ menopause, (stage 0‐4) using...

10.1002/hep.28514 article EN Hepatology 2016-02-26
Ju Dong Yang Manal F. Abdelmalek Cynthia D. Guy Ryan M. Gill Joel E. Lavine and 95 more Katherine P. Yates Jagpal S. Klair Norah A. Terrault Jeanne M. Clark Aynur Ünalp–Arida Anna Mae Diehl Ayako Suzuki Srinivasan Dasarathy Jaividhya Dasarathy Carol Hawkins Arthur J. McCullough Srinivasan Dasarathy Arthur J. McCullough Mangesh Pagadala Rish K. Pai Ruth Sargent Manal F. Abdelmalek Mustafa R. Bashir Stephanie Buie Anna Mae Diehl Cynthia D. Guy Christopher Kigongo Yi‐Ping Pan Dawn Piercy Naga Chalasani Oscar W. Cummings Samer Gawrieh Marwan Ghabril Smitha Marri Linda Ragozzino Kumar Sandrasegaran Raj Vuppalanchi Debra King Pat Osmack Joan Siegner Susan D. Stewart Brent A. Neuschwander‐Tetri Susan Torretta Brandon Ang Cynthia Behling Archana Bhatt Rohit Loomba Michael S. Middleton Heather Patton Claude B. Sirlin Bradley E. Aouizerat Nathan M. Bass Danielle Brandman Linda D. Ferrell Ryan M. Gill Bilal Hameed Cláudia Ramos Norah A. Terrault Ashley Ungermann Pradeep R. Atla Brandon Croft Rebekah Garcia Sonia García Muhammad Y. Sheikh Mandeep Singh Sherry Boyett Laura R. Carucci Melissa J. Contos Kenneth A. Kraft Velimir A. Luketic Prem Puri Arun J. Sanyal Jolene Schlosser Mohhamad S. Siddiqui Ben Wolford Sarah Ackermann Shannon Cooney David Coy Katie Gelinas Kris V. Kowdley Maximillian Lee Tracey Pierce Jody Mooney James E. Nelson Cheryl Shaw Asma Siddique Chia Wang Elizabeth M. Brunt Kathryn J. Fowler David E. Kleiner Gilman D. Grave Edward Doo Jay H. Hoofnagle Patricia R. Robuck Averell H. Sherker Patricia Belt Jeanne M. Clark Michele Donithan Erin Hallinan Milana Isaacson

10.1016/j.cgh.2016.07.034 article EN Clinical Gastroenterology and Hepatology 2016-08-12

Expert endoscopists previously reported ERCP outcomes for the first commercialized single-use duodenoscope. We aimed to document usability of this device by with different levels experience.Fourteen "expert" (>2000 lifetime ERCPs) and 5 "less-expert" performed consecutive ERCPs in patients without altered pancreaticobiliary anatomy. Outcomes included completion intended indication, rate crossover another endoscope, performance ratings, serious adverse events.Two hundred including 81 (40.5%)...

10.1016/j.gie.2021.06.017 article EN cc-by-nc-nd Gastrointestinal Endoscopy 2021-06-26

<b><i>Background:</i></b> Only a small proportion of patients with biliary tree infection grow microorganisms in blood cultures. Antibiotics chosen or tailored based on organisms identified cultures have potential for under-treatment and unfavorable outcomes, including recurrent early stent occlusion. In our current practice, we collect bile culture if an Endoscopic Retrograde Cholangio-Pancreatography (ERCP) is performed suspected cholangitis. this study, compare the...

10.1159/000493579 article EN Digestive Diseases 2018-10-03

Summary Background Guidelines recommend withholding sofosbuvir ( SOF ) in patients with an estimated glomerular filtration rate eGFR of less than 30 mL/min. Aim To assess the risk acute kidney injury AKI no renal contraindications for ‐based treatment. Methods This multicenter retrospective observational study included all consecutive that were treated or telaprevir/boceprevir (TVR/BOC)‐based regimens at two tertiary university centers North America. was defined as increase ≥0.3 mg/ dL...

10.1111/apt.14117 article EN Alimentary Pharmacology & Therapeutics 2017-05-03

Abstract Background Interval colorectal cancers may be associated with a low serrated polyp detection rate (SDR) and advanced adenoma (AADR). We aimed to determine the SDR AADR for endoscopists in United States multicenter cohort. Methods included average-risk screening colonoscopies from five medical centers States. Endoscopists data on at least 100 were included. calculated median adequate rates (ADRs) > 25 %. analyzed relationship between ADR SDR, using nonparametric Spearman...

10.1055/a-1031-5672 article EN Endoscopy 2019-11-18

Myasthenia gravis (MG) is a neuromuscular disorder that typically affects the ocular, bulbar, neck, proximal limbs and respiratory muscles. Dysphagia can occasionally be only presenting symptom leading to extensive but ultimately futile gastrointestinal workup. Delay in diagnosis use of certain pharmacological agents interim lead myasthenic crisis, which though diagnostic life threatening. We document case dysphagia as myasthenia, diagnosed after magnesium infusion precipitated crisis. A...

10.1136/bcr-2014-204163 article EN BMJ Case Reports 2014-04-17

Peroral endoscopic myotomy (POEM) is a novel procedure for the treatment of achalasia and spastic esophageal disorders. Experience with POEM limited, but its reported outcomes are excellent. It deemed safe even patients prior interventions.This retrospective review included who underwent at tertiary US center. was performed in multidisciplinary approach by advanced endoscopists foregut surgeons. Clinical success defined as post-POEM Eckardt score ≤3.A total 125 were included. Median...

10.5946/ce.2019.110 article EN cc-by-nc Clinical Endoscopy 2019-11-20

Hypermagnesemia is a rare and under-recognized cause of paralytic ileus. We report case 21-year-old primigravida who was managed aggressively for preeclampsia presented with postpartum Detailed history employed to consider hypermagnesemia-induced ileus as the working diagnosis, patient improved correction electrolyte imbalance. Hypermagnesemia-induced lethargy, decreased reflexes, muscle weakness, flaccid paralysis, respiratory cardiac arrest are well-described; however, intestinal smooth...

10.14309/crj.2015.67 article EN cc-by-nc-nd ACG Case Reports Journal 2015-01-01

Russell body gastritis (RBG) is a rare entity with unestablished pathophysiology, endoscopic findings, clinical manifestations and treatments. Literature scarce on this unclear significance. Of 18 cases reported, 12 tested (+) for Helicobacter pylori improved treatment, but it remains whether link coincidental or bears some We describe case of elderly woman who had follow-up oesophagogastroduodenoscopy chronic peptic ulcers, biopsy showed positive immunohistochemical stains κ λ, indicating...

10.1136/bcr-2013-202672 article EN BMJ Case Reports 2014-03-26

Tracheobronchopathia osteochondroplastica (TPO) is a rare disorder characterised by development of cartilaginous and bony nodules in the trachea. It usually affects elderly males with total prevalence disease reported to be around 0.1%. Even though multiple theories associations have been described, exact cause remains unknown. Its presentation non-specific many cases being diagnosed incidentally. Chronic cough dyspnoea are most common presenting symptoms, but some may present severe airway...

10.1136/bcr-2015-209860 article EN BMJ Case Reports 2015-06-25

<b><i>Background/Aims:</i></b> Serious gastrointestinal (GI) pathologies are common in older adults compared to young (≤40 years). Data on the diagnostic yield (DY) of colonoscopy with lower GI symptoms lacking. We aimed evaluate overall DY colonoscopy; and stratified by presence or absence bright red blood per rectum (BRBPR) ≤40 years. <b><i>Methods:</i></b> reviewed colonoscopies performed 18 gastroenterologists at 2 different institutions...

10.1159/000506073 article EN Digestive Diseases 2020-01-01

ABSTRACT Asparaginase is a part of combination chemotherapy for acute lymphoblastic leukemia. We present 58-year-old woman with refractory leukemia who developed asparaginase-induced hepatotoxicity after receiving intravenous PEG-L-asparaginase-based chemotherapy. The patient presented hyperbilirubinemia and transaminitis. was diagnosed drug-induced liver injury due to PEG-L-asparaginase thorough evaluation all other causes received treatment L-carnitine vitamin B complex normalization...

10.14309/crj.0000000000000194 article EN cc-by-nc-nd ACG Case Reports Journal 2019-08-01
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