A5081054849- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory Support and Mechanisms
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Shoulder Injury and Treatment
- Emergency and Acute Care Studies
- Shoulder and Clavicle Injuries
- Hip and Femur Fractures
- Pharmaceutical Practices and Patient Outcomes
- Primary Care and Health Outcomes
- Orthopedic Surgery and Rehabilitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Promotion and Cardiovascular Prevention
- Diabetes Management and Education
- Palliative Care and End-of-Life Issues
- Thermal Regulation in Medicine
- vaccines and immunoinformatics approaches
- Human-Animal Interaction Studies
- Veterinary Orthopedics and Neurology
- Healthcare Systems and Challenges
- Atherosclerosis and Cardiovascular Diseases
University of Liverpool
2020-2024
Blackpool Victoria Hospital
2020-2024
Blackpool Teaching Hospitals NHS Foundation Trust
2020-2023
Lancaster University
2022
University of Minnesota
2021
Le Moyne College
2021
Wildlife Information Liaison Development
2021
Newcastle upon Tyne Hospitals NHS Foundation Trust
2018
Royal Brompton Hospital
2017
Royal Veterinary College
2014
The aim of this study was to examine the behavioural and cranial/spinal responses alpacas culled by captive bolt shooting resulting pathophysiology injury. Ninety-six were shot (103 shots) in a range locations with penetrating gun (CBG). Ten (9.8%) incompletely concussed following first shot. No animals required more than two shots. Incorrectly placed shots accounted for all that displayed signs sensibility. Damage thalamus, hypothalamus, midbrain, medulla, cerebellum, parietal occipital...
To ascertain the level of psychological distress, using validated psychology tools, among British National healthcare workers (HCW) during first wave Covid-19 crisis.A multi-centre, anonymized, all-comer staff survey across 3 hospitals in Lancashire, England (April to June 2020), consisting Patient Health Questionnaire (PHQ-9), Perceived Stress Scale-10 (PSS-10), Generalized Anxiety Disorder-7 (GAD-7), and Impact Events Scale (IES-6).Among 1113 HCW, median (IQR) PHQ-9, GAD-7, PSS-10, IES-6...
Postoperative bleeding requiring re-exploration in cardiac surgery has been associated with complications impacting short-term outcomes and perioperative survival. Many aspects of decision-making for still remain controversial, especially hemodynamically stable patients significant but not acutely cumulating chest drain output. We investigated the impact re-exploratory on a "borderline population" CABG who experienced non-acute bleeding, that were critically hemodynamic unstable conditions.A...
Abstract Objectives Performing wedge resection rather than lobectomy for primary lung cancer remains controversial. Recent studies demonstrate no survival advantage non-anatomical compared to in patients with early-stage cancer. The objective of this study was investigate whether T1 tumours, is associated equivalent lobectomy. Methods This a retrospective cohort who underwent at the Lancashire Cardiac Centre between April 2005 and 2018. Patients were subjected multidisciplinary team...
Aims Frozen shoulder is a common, painful condition that results in impairment of function. Corticosteroid injections are commonly used for frozen and can be given as glenohumeral joint (GHJ) injection or suprascapular nerve block (SSNB). Both types have been shown to significantly improve pain range motion. It not currently known which superior terms relieving patients’ symptoms. This the protocol randomized clinical trial investigate effectiveness corticosteroid either GHJ SSNB. Methods...
Summary Our case highlights the finding of an abnormal pulmonary valve on 2D echocardiography, confirmed to be bicuspid morphology with 3D imaging. The use biplane imaging both in transthoracic and transoesophageal echocardiography routine three-dimensional views particularly are incremental value better delineating anatomy.
Objective To conduct a large-scale, single-centre retrospective cohort study to understand the impact of prior percutaneous coronary intervention (PCI) on long-term survival patients who then undergo artery bypass graft (CABG). Methods Between 1999 and 2017, total 11 332 underwent CABG at hospital in UK. The were stratified into those received PCI (n=1090) or no (n=10 242) CABG. A 1058 from each group matched using propensity score matching. Kaplan-Meier estimates used assess risk-adjusted...
Background Minimally invasive surgical approaches have gained popularity among patients and surgeons. The aim of this project was to assess the safety initiating aortic valve replacement via an anterior right thoracotomy program. Methods Between May 2015 2019, data all isolated primary replacements were extracted retrospectively from our prospectively collected database categorized into conventional median sternotomy, hemisternotomy, cases. In total, 661 underwent replacement, whom 429 (65%)...
Mutations in the p53 tumor suppressor are found over 50% of cancers. function is controlled through posttranslational modifications and cofactor interactions. In this study, we investigated posttranslationally modified p53, including acetylated at lysine 382 (K382), phosphorylated serine 46 (S46), TTC5/STRAP (Tetratricopeptide repeat domain 5/ Stress-responsive activator p300-TTC5) proteins lung cancer. Immunohistochemical (IHC) analysis cancer tissues from 250 patients was carried out...
Aims Steroid injections are used for subacromial pain syndrome and can be administered via the anterolateral or posterior approach to space. It is not currently known which superior in terms of improving clinical symptoms function. This protocol a randomized controlled trial (RCT) compare effectiveness steroid injection given Methods The Subacromial Approach Injection Trial (SAInT) study single-centre, parallel, two-arm RCT. Participants will allocated on 1:1 basis either both arms then...
<h3>Introduction</h3> Acute heart failure (AHF) hospitalisation is typically lengthy, costly and associated with 10% mortality. Outpatient based management (OPM) of AHF appeared effective in observational studies. We conducted a pilot randomised controlled trial (RCT) comparing OPM standard inpatient care (IPM). Hopelessness independently predicted mortality patients risk factors ischaemic disease. hypothesize that to may be more hopeful have better mental well-being, quality life, patient...
Multiple studies have suggested that women worse outcomes than men following mitral valve (MV) surgery-most of those reported on conventional sternotomy (CS) MV surgery. Therefore, we aimed to explore whether or not the minimally invasive surgery (MIMVS) approach might mitigate a survival in surgery.We identified patients with isolated primary operations without tricuspid repair performed between 2007 and 2019. Patients were propensity score-matched across MIMVS CS surgical approaches. Sex...
Objectives To examine the socioeconomic and demographic drivers associated with polypharmacy (5–9 medicines), extreme (9–20 medicines) increased medication count. Design, setting participants A total of 5509 participants, from two waves English North West Coast, Household Health Survey were analysed Outcome measures Logistic regression modelling was used to find associations polypharmacy. negative binomial identified Descriptive statistics explored management. Results Age number health...
<h3>Introduction</h3> Outpatient based management of heart failure is gaining popularity in the UK. Observation data and a small pilot randomised controlled trial suggested it safe clinically effective. However, cost-effectiveness this novel treatment approach not known. Patient level costing thought to be more accurate providing extra granularity when reviewing cost patient pathways. <h3>Methods</h3> We used Trust's models from financial years 2018/19 2019/20 calculate total costs for...
<h3>Introduction</h3> Worsening heart failure (HF) leading to hospital admission is common and associated with substantial morbidity mortality. For many patients, the preferred place of care, including end-of-life at home or in community, but this often thwarted by need for intravenous (IV) diuretic therapy. Alternative models ambulatory care exist safety efficacy should be compared standard randomised controlled trials (RCT). <h3>Methods</h3> We patients pulmonary peripheral oedema who no...