A5103256016- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Neonatal Respiratory Health Research
- Cardiovascular Disease and Adiposity
- Neonatal and fetal brain pathology
- Antiplatelet Therapy and Cardiovascular Diseases
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Metabolomics and Mass Spectrometry Studies
- Mechanical Circulatory Support Devices
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Ischemia and Reperfusion
- Congenital Heart Disease Studies
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Medical Imaging Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Pain Management and Treatment
- COVID-19 and Mental Health
- Ultrasound and Hyperthermia Applications
- Clinical practice guidelines implementation
- Cardiovascular Conditions and Treatments
University of Glasgow
2015-2024
Queen Elizabeth University Hospital
2020-2024
Rotunda Hospital
2008-2024
British Heart Foundation
2016-2023
NHS Greater Glasgow and Clyde
2020-2023
Golden Jubilee National Hospital
2015-2021
Royal College of Surgeons in Ireland
2021
Duke University
2020
Corcoran College of Art and Design
2019
Children's Hospital
2008
The aim of this study was to test the hypothesis that invasive coronary function testing at time angiography could help stratify management angina patients without obstructive artery disease.Medical therapy for guided by vascular holds promise, but longer-term effects on quality life and clinical events are unknown among disease.A total 151 with symptoms and/or signs ischemia no disease were randomized stratified medical an interventional diagnostic procedure versus standard care (control...
Determine the prevalence and correlates of microvascular vasospastic angina in patients with symptoms signs ischemia but no obstructive coronary artery disease (INOCA).Three hundred ninety-one were enrolled at 2 regional centers over 12 months from November 2016 (NCT03193294). INOCA subjects (n=185; 47%) had more limiting dyspnea (New York Heart Association classification III/IV 54% versus 37%; odds ratio [OR], 2.0 [1.3-3.0]; P=0.001) likely to be female (68% 38% disease; OR, 1.9 [1.5 2.5];...
Endothelin-1 (ET-1) is a potent vasoconstrictor peptide linked to vascular diseases through common intronic gene enhancer [(rs9349379-G allele), chromosome 6 (PHACTR1/EDN1)]. We performed multimodality investigation into the role of ET-1 and this variant in pathogenesis coronary microvascular dysfunction (CMD) patients with symptoms and/or signs ischaemia but no obstructive artery disease (CAD).
Abstract The pathophysiology and trajectory of post-Coronavirus Disease 2019 (COVID-19) syndrome is uncertain. To clarify multisystem involvement, we undertook a prospective cohort study including patients who had been hospitalized with COVID-19 (ClinicalTrials.gov ID NCT04403607 ). Serial blood biomarkers, digital electrocardiography patient-reported outcome measures were obtained in-hospital at 28–60 days post-discharge when imaging using chest computed tomography pulmonary coronary...
We investigated the usefulness of invasive coronary function testing to diagnose cause angina in patients with no obstructive arteries.
<b><i>Background:</i></b> Extremely preterm babies (delivered at <28 completed weeks of gestation) are frequently diagnosed with hypotension and treated inotropic pressor drugs in the immediate postnatal period. Dopamine is most commonly used first-line drug. Babies who for more sustain brain injury, have long-term disability or die compared to those not. Despite widespread use treat such infants, evidence efficacy lacking, effect these agents on outcomes unknown....
COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular involvement in remain unclear.This prospective, observational, multicentre, longitudinal, cohort study minimal selection criteria near-consecutive approach to screening. Patients who have received hospital care for will be enrolled within 28 days discharge. Myocardial injury diagnosed according the peak troponin I relation upper reference limit (URL,...
Purpose To assess myocardial strain using cine displacement encoding with stimulated echoes (DENSE) 1.5T and 3.0T MRI in healthy adults. Materials Methods Healthy adults without any history of cardiovascular disease underwent magnetic resonance imaging (MRI) at within 2 days. The protocol included balanced steady‐state free‐precession (b‐SSFP), 2D cine‐echo planar (EPI)‐DENSE, late gadolinium enhancement subjects >45 years. Acquisitions were divided into six segments; global segmental...
The benefits of routine invasive management in patients with prior coronary artery bypass grafts presenting non-ST elevation acute syndromes are uncertain because these were excluded from pivotal trials.In a multicenter trial, graft prospectively screened 4 hospitals. Medically stabilized randomized to (invasive group) or noninvasive (medical group). primary outcome was adherence the strategy by 30 days. A blinded, independent Clinical Event Committee adjudicated predefined composite...
Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain.There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) post-COVID-19 patients, and patient reported health outcomes following COVID-19 infection.This prospective study investigated time-course of multiorgan injury survivors during convalescence.Clinical information, blood biomarkers, outcome measures were prospectively acquired at enrolment...
Microvascular obstruction affects one-half of patients with ST-segment elevation myocardial infarction and confers an adverse prognosis. This study aimed to determine whether the efficacy safety a therapeutic strategy involving low-dose intracoronary alteplase infused early after coronary reperfusion associates ischemic time. was conducted in prospective, multicenter, parallel group, 1:1:1 randomized, dose-ranging trial undergoing primary percutaneous intervention. Ischemic time, defined as...
Introduction There is conflicting evidence regarding the benefits of percutaneous coronary intervention (PCI) in patients with grey zone fractional flow reserve ( GZ FFR artery) values (0.75–0.80). The prevalence ischaemia unknown. We wished to define artery and assess whether PCI superior optimal medical therapy (OMT) for angina control. Methods enrolled 104 1:1 randomisation or OMT. was interrogated a Doppler flow/pressure wire. Patients underwent Magnetic Resonance Imaging (MRI) follow-up...
First pass gadolinium-enhanced cardiovascular magnetic resonance (CMR) perfusion imaging allows fully quantitative pixel-wise myocardial blood flow (MBF) assessment, with proven diagnostic value for coronary artery disease. Segmental analysis requires manual segmentation of the myocardium. This work presents a automatic method segmenting left ventricular myocardium from MBF pixel maps, validated on retrospective dataset 247 clinical CMR studies, each including rest and stress images three...
Introduction Angina with no obstructive coronary artery disease (ANOCA) is a common syndrome unmet clinical needs. Microvascular and vasospastic angina are relevant but may not be diagnosed without measuring vascular function. The relationship between cardiovascular magnetic resonance (CMR)-derived myocardial blood flow (MBF) reference invasive function tests uncertain. We hypothesise that multiparametric CMR assessment will clinically useful in the ANOCA diagnostic pathway. Methods/analysis...