A5045180528- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Cardiac Ischemia and Reperfusion
- Hemodynamic Monitoring and Therapy
- Cardiovascular Issues in Pregnancy
- Healthcare Systems and Practices
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Medical Imaging Techniques and Applications
- MicroRNA in disease regulation
- ECG Monitoring and Analysis
- Clinical practice guidelines implementation
- Sulfur Compounds in Biology
- Biochemical effects in animals
- Diet and metabolism studies
- Inflammasome and immune disorders
- Pharmacology and Obesity Treatment
Policlinico Casilino
2020-2024
Università Cattolica del Sacro Cuore
2011-2022
Golden Jubilee National Hospital
2017-2021
University of Glasgow
2018
Agostino Gemelli University Polyclinic
2016-2018
Catholic University of America
2013
Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems be destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while 2 (T2) DM primary insulin resistance, rather defective production -cell destruction, triggering alteration. our study, we investigated role systemic...
The need of adenosine administration for the achievement maximal hyperaemia limits widespread application fractional flow reserve (FFR) in real world. We hypothesised that Pd/Pa ratio registered during submaximal reactive induced by conventional non-ionic radiographic contrast medium (contrast ratio: CMR) can be sufficient assessment physiological severity stenosis vast majority cases. aim present study was to test accuracy CMR comparison FFR.Eighty patients with 104 intermediate coronary...
Aims: Adenosine administration is needed for the achievement of maximal hyperaemia fractional flow reserve (FFR) assessment.The objective was to test accuracy Pd/Pa ratio registered during submaximal induced by non-ionic contrast medium (contrast FFR [cFFR]) in predicting and comparing it performance resting a collaborative registry 926 patients enrolled 10 hospitals from four European countries (Italy, Spain, France Portugal). Methods results:Resting Pd/Pa, cFFR were measured 1,026 coronary...
The benefits of routine invasive management in patients with prior coronary artery bypass grafts presenting non-ST elevation acute syndromes are uncertain because these were excluded from pivotal trials.In a multicenter trial, graft prospectively screened 4 hospitals. Medically stabilized randomized to (invasive group) or noninvasive (medical group). primary outcome was adherence the strategy by 30 days. A blinded, independent Clinical Event Committee adjudicated predefined composite...
Abstract Patients with acute coronary syndromes (ACS) and multivessel artery disease are frequently encountered during clinical practice those patients at higher risk of subsequent cardiovascular events. In presenting both ST-segment elevation myocardial infarction non-ST-segment syndromes, complete revascularization is associated decreased major adverse Nevertheless, the optimal timing intervention treatment modality still in discussions. Furthermore, non-culprit lesions assessment based on...
Background: The aim of this study was to assess the relationship among anthropometric indexes adiposity (body mass index [BMI], waist circumference [WC]), endothelial progenitor cells (EPC) and carotid intima-media thickness (IMT) in patients with morbid obesity, effect diabetes weight loss. Methods Results: BMI, WC, IMT circulating EPC (defined as CD34+/KDR+/CD45- cells) were assessed 100 (37 diabetes). Fifty underwent bariatric surgery, 48 them a complete re-assessment after an average...
Abstract The treatment of calcific coronary lesions is still a major interventional issue in haemodynamics laboratories. prevalence the disease even increasing, considering general ageing population undergoing coronarography, as well often associated comorbidities. In recent years, new devices have been developed that allow both better identification and also these lesions. aim this review to summarize imaging modalities dedicated techniques materials, thus providing kind compendium for approach.
There are limited data about the intraprocedural haemodynamic study performed immediately before and after transcatheter aortic valve implantation (TAVI) in patients with severe stenosis (AS). We aimed to evaluate acute impact of TAVI AS investigate invasive non-invasive parameters predicting all-cause mortality.A total 245 consecutive (43% male, mean age 80.3 ± 7.3 years) undergoing were enrolled. Intraprocedural left heart catheterization (LHC) echocardiogram performed. The clinical...
While the importance of invasive physiological assessment (IPA) to choose coronary lesions be treated is ascertained, its role after PCI less established. We evaluated feasibility and efficacy Physiology-guided in everyday practice a retrospective registry performed single high-volume "physiology-believer" center. The PROPHET-FFR study (NCT05056662) patients undergoing an IPA 2015-2020 were retrospectively enrolled three groups: Control group comprising for whom was deferred based on IPA;...
Stent implantation in ST-segment elevation myocardial infarction (STEMI) patients can be challenging and sometimes associated with immediate long-term suboptimal results. malapposition strut uncoverage, predictors of stent thrombosis, are frequently detected STEMI at medium/long-term follow-up. Nevertheless, data a short follow-up missing. We aimed to assess the extent struts coverage subacute phase after primary or rescue percutaneous coronary intervention (PCI).STEMI undergone PCI...
Purpose: To assess the effects of bariatric surgery (BS) on cardiac mass, volumes and function as compared to persistent morbid obesity. Although beneficial weight loss have been reported, systematic studies effect BS obesity are lacking. Methods: One-hundred morbidly obese patients (body mass index -BMI- 47.7±7 kg/m2) referred for prospectively underwent an echocardiogram: 65 35 did not. Fifty-one operated 29 non-operated repeat imaging after 2 years. Results: Operated showed a significant...
Despite the fact that fractional flow reserve (FFR) is better than angiography in guiding PCI, real world choice to perform PCI generally based on angiography. Three-dimensional quantitative coronary (3D-QCA) may increase accuracy of angiography, especially intermediate artery stenosis (ICAS). The aim study was assess best cut-off values area % (AS%) and extent jeopardised myocardium for predicting FFR excluding need FFR.FFR, AS% Myocardial Jeopardy Index (MJI) were assessed 211 ICAS. MJI...