A5003002456- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Cardiac tumors and thrombi
- Cardiac Imaging and Diagnostics
- COVID-19 and healthcare impacts
- Vascular Procedures and Complications
- Congenital heart defects research
- Technology Use by Older Adults
- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- Cardiovascular Issues in Pregnancy
- Atrial Fibrillation Management and Outcomes
- Hip and Femur Fractures
- Venous Thromboembolism Diagnosis and Management
- Colorectal Cancer Surgical Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
Agostino Gemelli University Polyclinic
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
Università Cattolica del Sacro Cuore
2015-2024
Fondazione Roma
2023
Bambino Gesù Children's Hospital
2023
Catholic University of America
2015
The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine release, immunosuppression. This condition has led to death of about 2.15% total infected world population so far. Among survivors, presence so-called persistent post-COVID-19 (PPCS) is a common finding. In PPCS presents one or more symptoms: fatigue, dyspnea, memory loss, sleep disorders, difficulty concentrating. this...
Background: According to current guidelines, patients with heart valve disease should be followed by Heart Valve Clinics (HVCs). Regular quality analysis is a major prerequisite of an HVC’s program, but few data have been reported so far. Methods: We retrospectively collected isolated, native aortic stenosis who had visited in our HVC at least once between 2021 and 2024. For each outpatient visit, symptoms, physical examination, echocardiographic data, complementary tests, indications were...
Cardiac impantable electronic device infective endocarditis (CIED-IE) is a life-threatening condition. We report 2 cases of large in which differences surgical timing affected outcomes. Patients with CIED-IE should be referred to hub center experienced specialists and undergo early complete extraction without unnecessary delay.
Abstract Background Advances in minimally invasive cardiac surgery require accurate preoperative assessment of the morphology and function mitral valve apparatus. The success repair with annuloplasty depends on correct sizing annulus ring (1) (2). Three-dimensional transoesophageal echocardiography (3D-TOE) has been proven to be essential for anatomo-functional characterization apparatus patients undergoing surgically (3). It also allows measurement quantitative parameters useful determining...
Abstract Background The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG). An algorithm is also established to determine how pathophysiological condition might influence human biological age. Results Blood samples and auricles were collected from who underwent procedures: 94 AVR 289 CABG. CpGs three independent blood-derived clocks selected design...
Abstract Aims Lung ultrasound (LUS) is a sensitive tool to assess pulmonary congestion (PC). Few data are available on LUS‐PC evaluation in patients with severe aortic stenosis (AS) undergoing transcatheter valve implantation (TAVI). The aim of this study was the prevalence and prognostic impact AS before after TAVI. Methods results We designed single‐centre prospective referred for TAVI ( ClinicalTrials.gov identification number: NCT05024942). All underwent echocardiography LUS (according...
ABSTRACT Introduction & Background the SARS-CoV-2 infection determines COVID19 syndrome characterized, in worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokines release, immunosuppression. This condition has led to death of about 2.15% total infected world population so far. Among survivors, presence so-called persistent post-COVID19 (PPCS) is a common finding. In patients who survived infection, overt PPCS presents one or more symptoms such...
Background A multidisciplinary approach might be pivotal for the management of patients with valvular heart disease (VHD), but clinical outcome data are lacking. Methods and Results At our institution, since 2014, internal guidelines recommended team consultations VHD. The clinical/echocardiographic characteristics, treatment recommendations, performed treatment, early outcomes consecutive, hospitalized VHD undergoing evaluation were collected. Surgical risk was prospectively assessed by...
There are limited data about the intraprocedural haemodynamic study performed immediately before and after transcatheter aortic valve implantation (TAVI) in patients with severe stenosis (AS). We aimed to evaluate acute impact of TAVI AS investigate invasive non-invasive parameters predicting all-cause mortality.A total 245 consecutive (43% male, mean age 80.3 ± 7.3 years) undergoing were enrolled. Intraprocedural left heart catheterization (LHC) echocardiogram performed. The clinical...
Despite claims of feasibility, to date no study has examined the effect systematic bilateral internal mammary artery (BIMA) use in a large cohort real-world unselected patients. The CATHolic University EXtensive BIMA Grafting Study (CATHEXIS) registry was designed assess feasibility and safety grafting. CATHEXIS single-centre, prospective, observational, propensity-matched study. supposed include 2 arms 500 patients each: prospective arm retrospective arm. included almost all referred for...
Obese patients are at risk of complications after cardiac surgery. The aim this study is to investigate safety and efficacy a minimally invasive approach via upper sternotomy in setting.
Ascending aorta (AA) dilatation in patients with bicuspid aortic valve (AV) is related both to genetic and haemodynamic factors. The aim of this study compare late progression AA AV undergoing surgical replacement (SAVR) versus transcatheter implantation (TAVI).
New-generation transcatheter-heart-valves (THV) have significantly improved technical success and procedural safety of transcatheter-aortic-valve-implantation (TAVI) procedures, but incidence permanent pacemaker implantation (PPI) remains a concern.The study aimed to assess the role anatomical annulus features in determining peri-procedural conduction disturbances leading new-PPI following TAVI with last generation Edwards Sapien balloon-expandable valves (BEV). In context prospective...
Objective Despite conflicting evidence available, minimally invasive aortic valve replacement (MIAVR) is increasingly used as an alternative to full sternotomy. We sought compare early outcomes of through a sternotomy (conventional [CAVR]) and upper ministernotomy (MIAVR). Methods analyzed 297 patients having undergone primary, elective, isolated MIAVR or CAVR between January 2014 June 2018. Following propensity score matching, 120 remained in each group. Results required longer bypass (93 ±...
Clinical benefits of minimally invasive cardiac valve surgery (MIVS) have been reported. Improved postoperative mental status was never analyzed with dedicated psychological tests. In the present study we intend to investigate potential MIVS for patient well-being, special attention relevance perception chest surgical scar, self body image and cosmetic aspects.Between 2016 2017, 87 eligible patients, age 66.5 ± 14.5 years, operated on heart surgery, underwent either conventional full...
Objectives Aortic valve replacement (AVR) in patients with small aortic annulus (diameter ≤21 mm) is considered a challenging scenario because of technical aspects and the high risk patient-prosthesis mismatch (PPM). The choice appropriate prosthesis crucial, at moment, an ideal device has yet to be identified. We compare clinical hemodynamic results after AVR three bioprostheses different design characteristics. Methods retrospectively evaluated 76 consecutive from two cardiac surgery...
Background Transcatheter aortic valve implantation and rapid-deployment replacement represent two emerging therapies for patients with intermediate surgical risk severe stenosis. However, head-to-head comparisons between such novel are lacking. Methods Severe stenosis treated at our institution were identified compared a propensity-matched population of who underwent transcatheter replacement. Postoperative echocardiographic findings, in-hospital midterm clinical outcomes compared. Results...
An association between atrial myxoma and left ventricular failure is rarely described, not completely understood, may have multiple etiologies. We present a 49-year-old man with no history of cardiovascular disease who was admitted to our hospital pulmonary edema. He in fibrillation rapid response. Echocardiography showed 10.5-cm myxoma, which had been asymptomatic until the onset congestive heart presence severe systolic dysfunction. Left inflow obstruction associated giant mass could be...
Surgical ventricular reconstruction (SVR) is the therapy of choice for patients with left dilatation, apical and anterolateral transmural scar, low ejection fraction. STICH trial did not show that SVR led to improved survival but several observational studies did. However, because considerable operative risk, open heart surgery considered risky in debilitated clinical results are controversial. Alternative less invasive strategies aneurysm repair have been proposed. We present a case using...