A5100769113- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Eicosanoids and Hypertension Pharmacology
- Immune cells in cancer
- Occupational exposure and asthma
- Platelet Disorders and Treatments
- RNA modifications and cancer
- Heparin-Induced Thrombocytopenia and Thrombosis
- Indoor Air Quality and Microbial Exposure
- Asthma and respiratory diseases
- Intramuscular injections and effects
- Toxin Mechanisms and Immunotoxins
- Contact Dermatitis and Allergies
- Phytochemical compounds biological activities
- Hepatitis Viruses Studies and Epidemiology
- Advanced Computing and Algorithms
- Virology and Viral Diseases
- Pelvic floor disorders treatments
- Phagocytosis and Immune Regulation
- Vaccine Coverage and Hesitancy
- Immune responses and vaccinations
- T-cell and B-cell Immunology
- Urinary Bladder and Prostate Research
- Antioxidant Activity and Oxidative Stress
- Medicinal Plant Pharmacodynamics Research
Zhengzhou University
2012-2024
Henan Provincial People's Hospital
2023-2024
Hebei Medical University
2023
Second Hospital of Hebei Medical University
2023
University of North Carolina at Chapel Hill
2018
Shenzhen University
2016
Yale University
2011-2015
Second Affiliated Hospital of Zhejiang University
2005
Zhuzhou Central Hospital
2003
Army Medical University
1998
Methylene diphenyl diisocyanate (MDI), a reactive chemical used for commercial polyurethane production, is well-recognized cause of occupational asthma. The major focus disease prevention efforts to date has been respiratory tract exposure; however, skin exposure may also be an important route inducing immune sensitization, which promote subsequent airway inflammatory responses. We developed murine model investigate pathogenic mechanisms by MDI might responses, including inflammation.Mice...
Summary Recent studies have shown that ultra-large complexes (ULCs) of platelet factor 4 (PF4) and heparin (H) play an essential role in the pathogenesis heparin-induced thrombocytopenia (HIT), immune-mediated disorder caused by PF4/H antibodies. Because antigenic ULCs assemble through non-specific electrostatic interactions, we reasoned disruption charge-based interactions can modulate immune response to antigen. We tested a minimally anticoagulant compound (2-O, 3-O desulfated heparin,...
Tumour cells are characterized by aerobic glycolysis, which provides biomass for tumour proliferation and leads to extracellular acidification through efflux of lactate via monocarboxylate transporters (MCTs). Deficient spasm-prone vasculature causes variable hypoxia, favours cell survival metastases. Brain metastases frequently occur in patients with advanced breast cancer.Effective treatment strategies therefore needed against brain metastasis from carcinoma. In order identify differences...
Isocyanates have been a leading chemical cause of occupational asthma since their utility for generating polyurethane was first recognized over 60 years ago, yet the mechanisms isocyanate pathogenesis remain unclear. The present study provides in vivo evidence that GSH mediated pathway underlies asthma-like eosinophilic inflammatory responses to respiratory tract exposure. In naïve mice, mixture reaction products with allergen, methylene-diphenyl diisocyanate (MDI), induced innate immune...
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a potent immunoregulatory molecule that suppresses antitumor response by downregulating T cell activation. The most studied CTLA-4 +49A/G polymorphism has been associated with various cancers risks. However, little known about the association between and bladder cancer risk. A hospital-based case–control study was conducted in 300 patients healthy controls matched age sex. genotyped using polymerase chain reaction-restriction fragment length...
Tangeretin (Tan), a citrus flavonoid, possesses strong anti-tumor efficacy in various human cancers. However, the precise role of Tan development esophageal squamous cell carcinoma (ESCC) remains unclear. RNA sequencing (RNA-seq) analysis was performed to observe Tan-related genes Tan-treated TE-1 cells. The direct relationship between GLI family zinc finger 2 (GLI2) and promoter glycoprotein non-metastatic melanoma protein B (GPNMB) predicted by bioinformatics validated luciferase reporter...
Abstract Background Lung squamous cell carcinoma (LUSC) is a highly invasive malignancy associated with poor prognosis. Anoikis plays crucial role in the malignant progression of various cancers. However, studies focusing on anoikis LUSC are needed. Methods A total 357 anoikis-related genes (ARGs) were obtained from GeneCards database and Harmonizome portals. Univariate Cox regression was used to identify prognostic ARGs for patients LUSC, R package ConsensusClusterPlus determine subtypes....
Background. Anoikis, a form of programed cell death, plays pivotal role in the invasion and metastasis various tumors, including lung squamous carcinoma (LUSC). This study aims to construct prognostic model for LUSC, leveraging anoikis-related genes (ARGs). Methods. A total 357 ARGs were extracted from GeneCards database Harmonizome portals. Subsequently, influencing LUSC patients’ prognosis identified using univariate Cox regression analysis. Unsupervised clustering analysis was carried out...
Decreased locomotor activity and altered urinary frequency are induced by bilateral common iliac vein ligation in rats. As a carotenoid, lycopene has strong anti-oxidative function. This research investigated the function of pelvic venous congestion (PC) rat model underlying molecular mechanism. Lycopene olive oil were administered intragastrically on daily basis for 4 weeks after successful modeling. Locomotor activity, voiding behavior, continuous cystometry analyzed. The levels...