Angelika Wientzek
A5017654607- Tryptophan and brain disorders
- Gut microbiota and health
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- Mental Health Research Topics
- Cancer survivorship and care
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Health, Environment, Cognitive Aging
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Childhood Cancer Survivors' Quality of Life
- Health and Wellbeing Research
- Gallbladder and Bile Duct Disorders
- Bone health and osteoporosis research
- Cancer Risks and Factors
- Ultrasound Imaging and Elastography
- Magnesium in Health and Disease
- Health Systems, Economic Evaluations, Quality of Life
- Alzheimer's disease research and treatments
- Behavioral Health and Interventions
- Nutritional Studies and Diet
- Nutrition and Health in Aging
Daiichi Sankyo (Germany)
2020-2024
Roche (Bosnia-Herzegovina)
2017
Roche (United Kingdom)
2016
German Institute of Human Nutrition
2012-2015
Centre de recherche en Epidémiologie et Santé des Populations
2013
Norwegian Institute of Public Health
2013
Imperial College London
2013
Inserm
2012-2013
Hellenic Health Foundation
2012
Aarhus University Hospital
2012
It is not yet resolved how lifestyle factors and intermediate phenotypes interrelate with metabolic pathways. We aimed to investigate the associations between diet, physical activity, cardiorespiratory fitness obesity serum metabolite networks in a population-based study.The present study included 2380 participants of randomly drawn subcohort European Prospective Investigation into Cancer Nutrition-Potsdam. Targeted metabolomics was used measure 127 metabolites. Additional data were...
Physical activity is associated with reduced risks of invasive breast cancer. However, whether this holds true for cancer subtypes defined by the estrogen receptor (ER) and progesterone (PR) status controversial. The study included 257,805 women from multinational EPIC-cohort detailed information on occupational, recreational household physical important cofactors assessed at baseline. During 11.6 years median follow-up, 8,034 incident cases were identified. Data ER, PR combined ER/PR...
Imbalances in tryptophan metabolism have been linked to cancer-related immune escape and implicated several cancers, including lung cancer.
Gallstones are common disorders associated with several cardiovascular risk factors. Gallstone formation and atherosclerosis may share key pathways, but studies on putative associations between gallstones the of disease sparse non-conclusive. We studied relationship subsequent diseases in German arm European Prospective Investigation into Cancer Nutrition (EPIC). The study comprises 46,468 participants from EPIC-Potsdam EPIC-Heidelberg aged 35-65 years, free diabetes at baseline. Information...
Real-world evidence (RWE) is increasingly used for medical regulatory decisions, yet concerns persist regarding its reproducibility and hence validity. This study addresses challenges associated with diversity across real-world data sources (RWDS) repurposed secondary use in pharmacoepidemiologic studies. Our aims were to identify, describe characterize practices, recommendations tools collecting reporting RWDSs, explore how leveraging could improve the quality of evidence.
To quantify the independent associations between objectively measured physical activity (PA), cardiorespiratory fitness (CRF), and anthropometry in European men women.2,056 volunteers from 12 centers across Europe were fitted with a heart rate movement sensor at 2 visits 4 months apart for total of 8 days. CRF (ml/kg/min) was estimated an minute ramped step test. A cross-sectional analysis PA (m/s(2)/d), moderate vigorous (MVPA) (%time/d), sedentary time CRF, using sex stratified multiple...
The aim of our study was to investigate the relationship between objectively measured physical activity (PA) and cardiorespiratory fitness (CRF) serum metabolites by targeted metabolomics in a population- based study. A total 100 subjects provided 2 fasting blood samples engaged CRF PA measurement at visits 4 months apart. estimated from step test, whereas energy expenditure (PAEE), time spent sedentary spend vigorous were combined heart rate movement sensor for 8 days. Serum metabolite...
In the European Investigation into Cancer and Nutrition study (EPIC), physical activity (PA) has been indexed as a cross-tabulation between PA at work recreational activity. As proportion of non-working participants increases, other categorization strategies are needed. Therefore, our aim was to develop valid index for this population, which will also be able express continuously. German EPIC centers Potsdam Heidelberg, clustered sample 3,766 re-invited center. 1,615 agreed participate 1,344...
Physical activity (PA) is suggested to increase the peak bone mass and minimize age-related loss, thereby reduce risk of osteoporosis. However, relation between PA health considering obesity status unclear so far. The present study examines association levels calcaneal broadband ultrasound attenuation (BUA), particularly under consideration obesity. Data from a population-based sample 6776 German women EPIC-Potsdam cohort were analyzed. Calibrated data used. Statistical analyses stratified...
Abstract Background: Physical activity has been identified as protective factor for invasive breast cancer risk, whereas comparable studies on in situ carcinoma are rare. Methods: The study included data from 283,827 women of the multinational European Prospective Investigation into C7ancer and Nutrition (EPIC)-cohort study. Detailed information different types physical conducted during prior year, such occupational, recreational, household activity, well important cofactors, was assessed at...
Vascular risk factors may increase the for Alzheimer’s disease (AD). Recently, International Working Group-2 (IWG-2) and National Institute of Aging-Alzheimer’s Association (NIA-AA) proposed criteria diagnosis AD in subjects with MCI. The current study aimed to investigate whether vascular are associated prodromal cognitive decline. We selected from multicenter studies (DESCRIPA, DCN, EDAR, EADC-PET, ADNI) 7 centers EADC and/or EMIF-AD (Antwerp, Barcelona, Brescia, Coimbra, Gothenburg, Liège...
<div>Abstract<p><b>Background:</b> Imbalances in tryptophan metabolism have been linked to cancer-related immune escape and implicated several cancers, including lung cancer.</p><p><b>Methods:</b> We conducted a nested case–control study within the European Prospective Investigation into Cancer Nutrition (EPIC) that included 893 incident cancer cases 1,748 matched controls. Circulating levels of six its metabolites were measured evaluated...
<p>PDF file - 113K, Odds ratios with 95% Confidence Intervals (CI) of lung cancer for circulating levels Tryptophan, Kynurenine and Kynurenine/Tryptophan ratio by smoking status. P trend were assessed the base 2 logarithm levels.</p>
<p>PDF file - 100K, Odds Ratios with 95% Confidence Intervals (CI) of Lung Cancer for circulating levels Tryptophan, Kynurenine and Kynurenine/Tryptophan ratio by histological type. P trend were assessed the base 2 logarithm levels.</p>
<p>PDF file - 90K, Linear regression for circulating Tryptophan, Kynurenine and Kynurenine/tryptophan ratio in relation to food groups, lifestyle factors other biomarkers of a nested case-control study the EPIC cohort. Ratios concentrations with 95% Confidence Intervals (CI) were calculated as 2 raised power beta estimates from linear models log2-circulating response.</p>
<p>PDF file - 71K, Spearman partial correlation coefficients between biomarkers among controls of a nested case-control study in the EPIC cohort.</p>
<p>PDF file - 98K, Odds ratios with 95% Confidence Intervals (CI) of lung cancer for circulating levels Kynurenic acid, 3-Hydroxykynurenine, Anthralinic Xanthurenic 3-Hydroxyantranilic acid and Neopterine. P trend were assessed by the base 2 logarithm levels.</p>
<p>PDF file - 71K, Spearman partial correlation coefficients between biomarkers among controls of a nested case-control study in the EPIC cohort.</p>
<p>PDF file - 100K, Odds Ratios with 95% Confidence Intervals (CI) of Lung Cancer for circulating levels Tryptophan, Kynurenine and Kynurenine/Tryptophan ratio by histological type. P trend were assessed the base 2 logarithm levels.</p>
<p>PDF file - 98K, Odds ratios with 95% Confidence Intervals (CI) of lung cancer for circulating levels Kynurenic acid, 3-Hydroxykynurenine, Anthralinic Xanthurenic 3-Hydroxyantranilic acid and Neopterine. P trend were assessed by the base 2 logarithm levels.</p>