A5028800598- Nutritional Studies and Diet
- Inflammatory Bowel Disease
- Microscopic Colitis
- Adipokines, Inflammation, and Metabolic Diseases
- Consumer Attitudes and Food Labeling
- Antioxidant Activity and Oxidative Stress
- Parathyroid Disorders and Treatments
- Eosinophilic Esophagitis
- Fatty Acid Research and Health
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Biomarkers in Disease Mechanisms
- Cancer, Lipids, and Metabolism
- Alcohol Consumption and Health Effects
- Adipose Tissue and Metabolism
- Vitamin D Research Studies
- Fibroblast Growth Factor Research
- Diet and metabolism studies
- Selenium in Biological Systems
- Nutrition and Health in Aging
- Biosimilars and Bioanalytical Methods
- Diet, Metabolism, and Disease
- Trace Elements in Health
- Nutrition, Genetics, and Disease
- Cholesterol and Lipid Metabolism
Clinical Research Center Kiel
2022-2025
University of Trieste
2023
IRCCS Materno Infantile Burlo Garofolo
2023
Kompetenznetz Darmerkrankungen
2020-2022
Zimmer Biomet (Germany)
2021-2022
Kiel University
2016-2020
University Hospital Schleswig-Holstein
2017-2020
University of Lübeck
2017-2020
German Institute of Human Nutrition
2011-2017
German Centre for Cardiovascular Research
2015
The group of colorectal cancer (CRC) survivors continues to grow worldwide. Understanding health-related quality life (HRQOL) determinants and consequences HRQOL impairments in long-term CRC may help individualize survivorship care plans. We aimed i) examine the status survivors, ii) identify cross-sectional sociodemographic clinical correlates HRQOL, iii) investigate prospective association after diagnosis with all-cause mortality. assessed within a Northern German cohort 1294 at median 6...
Bile acids play an active role in fat metabolism and, high-fat diets, elevated concentrations of fecal bile may be related to increased risk colorectal cancer. This study investigated and serum 36 vegans omnivores. The reduced rank regression was used identify dietary patterns associated with acids. Dietary were derived secondary conjugated as response variables 53 food groups predictors. Vegans had higher fiber (p < 0.01) lower = 0.0024) intake than In serum, primary glycine-conjugated...
Gallstones are common disorders associated with several cardiovascular risk factors. Gallstone formation and atherosclerosis may share key pathways, but studies on putative associations between gallstones the of disease sparse non-conclusive. We studied relationship subsequent diseases in German arm European Prospective Investigation into Cancer Nutrition (EPIC). The study comprises 46,468 participants from EPIC-Potsdam EPIC-Heidelberg aged 35-65 years, free diabetes at baseline. Information...
Omentin is a novel biomarker shown to exert metabolic, inflammatory, and immune-related properties thereby could be implicated in the risk of colorectal cancer. So far, association between omentin cancer has not been evaluated prospective cohort studies. We investigated prediagnostic plasma concentrations case-cohort comprising 251 incident cases diagnosed over mean follow-up time 10.4 years 2,295 persons who remained free European Prospective Investigation into Cancer Nutrition-Potsdam...
Bone mineral metabolism may play a role in the development of heart failure (HF).The aim study was to investigate relationships plasma fibroblast growth factor (FGF) 23, PTH, and 25-hydroxyvitamin D3 [25(OH)D3] with incident congestive HF population-based cohort men women aged 40-65 35-65 years, respectively, at baseline.We conducted prospective case-cohort nested within European Prospective Investigation into Cancer Nutrition (EPIC)-Potsdam cohort, including randomly drawn sample total free...
We aimed to relate circulating α- and γ-tocopherol levels a broad spectrum of adiposityrelated traits in cross-sectional Northern German study. Anthropometric measures were obtained, adipose tissue volumes liver fat quantified by magnetic resonance imaging 641 individuals (mean age 61 years; 40.6% women). Concentrations measured using high performance liquid chromatography. Multivariable-adjusted linear logistic regression used assess associations γ-tocopherol/cholesterol ratio with visceral...
Increased fibroblast growth factor 23 (FGF23), a bone-derived hormone involved in the regulation of phosphate and vitamin D metabolism, has been related to development cardiovascular disease (CVD) chronic kidney patients general population. However, what determines higher FGF23 levels is still unclear. Also, little known about influence diet on FGF23. The aim this study was therefore identify demographic, clinical dietary correlates high concentrations population.We performed cross-sectional...
Little is known about the distribution and determinants of circulating vitamin E levels in a German population. In this cross-sectional study we assessed both α- γ-tocopherol levels, identified their clinical biochemical correlates, relationships with priori posteriori derived dietary patterns. Plasma concentrations were measured using high performance liquid chromatography (HPLC) fluorescence detection 641 individuals (mean-age: 61 years; 40.6% women). Correlates markers determined linear...
Lifestyle recommendations for cancer survivors are warranted to improve survival. In this study, we aimed examine the association of total physical activity, different types hours sleeping at day and night, spent watching television (TV) with all-cause mortality in long-term colorectal (CRC) survivors.We assessed activity 1376 CRC (44% women; median age, 69 years) 6 years after diagnosis using a validated questionnaire. Multivariable-adjusted Cox regression models were used estimate hazard...
Abstract Background Accumulating evidence indicates that trimethylamine-N-oxide (TMAO) may play a causal role in cardiovascular disease (CVD), chronic kidney (CKD) and type 2 diabetes (T2D). TMAO plasma concentrations show considerable intra- inter-individual variation, underscoring the need for reference interval general population to identify elevated concentrations. Methods were determined using an LC-MS/MS assay community-based sample of PopGen control cohort consisting 694 participants...
Summary Background This observational real‐world evidence (RWE) study is based on prospectively collected data from the VEDO IBD registry study. Aim To compare effectiveness of vedolizumab and anti‐TNF agents in biologic‐naïve patients with ulcerative colitis (UC) at end induction during maintenance treatment. Methods Between 2017 2020, we enrolled 512 UC starting therapy or an agent 45 centres across Germany. We excluded biologic‐experienced those missing partial Mayo (pMayo) outcomes; this...