A5023642484- SARS-CoV-2 and COVID-19 Research
- Urinary Tract Infections Management
- COVID-19 Clinical Research Studies
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Long-Term Effects of COVID-19
- Emergency and Acute Care Studies
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Geriatric Care and Nursing Homes
- SARS-CoV-2 detection and testing
- COVID-19 and Mental Health
- COVID-19 and healthcare impacts
- COVID-19 epidemiological studies
- Pelvic floor disorders treatments
- Streptococcal Infections and Treatments
- Infection Control and Ventilation
- Viral Infections and Outbreaks Research
- Gut microbiota and health
- Reproductive tract infections research
- Urinary Bladder and Prostate Research
- Healthcare Decision-Making and Restraints
- Respiratory viral infections research
- Hepatitis C virus research
- Syphilis Diagnosis and Treatment
GGD Zuid Limburg
2015-2025
Maastricht University
2014-2025
Maastricht University Medical Centre
2013-2023
United States Public Health Service
2021
Pharmo Institute
2019
Huisarts en Wetenschap
2013
International Center for Public Health
2011
Abstract Background We evaluated the risk of pelvic inflammatory disease (PID), ectopic pregnancy, and infertility in women with a previous Chlamydia trachomatis (CT) diagnosis compared who tested negative for CT untested women, considering both targeted incidental (ie, prescribed another indication) use CT-effective antibiotics. Methods This was retrospective study aged 12–25 years at start follow-up within Clinical Practice Research Datalink GOLD database linked to index multiple...
The human microbiota represents an important reservoir of antibiotic resistance. Moreover, the majority antibiotics are prescribed in primary care. For this reason, we assessed prevalence and resistance nasal carriage strains Streptococcus pneumoniae, most prevalent bacterial causative agent community-acquired respiratory tract infections, outpatients nine European countries. Nasal swabs were collected between October 2010 May 2011, from 32,770 patients, recruited by general practices...
Streptococcus pneumoniae is a commensal of the human upper respiratory tract and major cause morbidity mortality worldwide. This paper presents distribution serotypes antimicrobial resistance in S. strains cultured from healthy carriers older than four years age nine European countries.Nasal swabs persons (age between 4 107 old) were obtained by general practitioners each country November 2010 to August 2011. Swabs for using standardized protocol. Antibiotic was determined isolated broth...
Exercise-based treatments can worsen/exacerbate symptoms in people who were SARS-CoV-2 positive and living with post-COVID-19 condition (PL-PCC) have post-exertional malaise (PEM) or orthostatic intolerance (OI). Nevertheless, PEM OI are not routinely assessed by clinicians. We estimated proportions PL-PCC, as well PCC (PnL-PCC) negatives (i.e., never reported a test), identified associated factors.
ObjectivesTo optimize empirical treatment of urinary tract infections (UTIs), regular evaluation the antibiotic susceptibility most common uropathogen, Escherichia coli, is necessary. We compared prescription rate for UTIs in women and E. coli results, including prevalence extended-spectrum β-lactamase (ESBL)-producing strains, 2009 with data collected 5 years earlier.
Antimicrobial resistance (AMR) has become a global public health concern which threatens the effective treatment of bacterial infections. Resistant Staphylococcus aureus (including MRSA) increasingly appears in individuals with no healthcare associated risks. Our study assessed risk factors for nasal carriage resistant S. multinational, healthy, community-based population, including ecological exposure to antibiotics.Data were collected eight European countries (Austria, Belgium, Croatia,...
Over 90% of all antibiotics in Europe are prescribed primary care. It is important that likely to be effective; however, information about antibiotic resistance the community incomplete. The aim our study investigate appropriateness prescribing care by collecting and combining patterns prescription We will also evaluate national guidelines relation patterns. Antibiotic studied an opportunistic sample from nine European countries. Resistance data collected taking a nose swab persons (N =...
Abstract Background Long-term symptoms after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (ie, post–coronavirus disease 2019 [COVID-19] condition or long COVID) constitute substantial public health problem. Yet, the prevalence remains currently unclear as different case definitions are used, and negatively tested controls lacking. We aimed to estimate post-COVID-19 using 6 definitions. Methods The Prevalence, Risk factors, Impact Evaluation (PRIME) study is...
Undetected chronic hepatitis B virus (HBV) and C (HCV) infections can lead to cirrhosis liver cancer. Syrian migrants are the largest non-European migrant group in Netherlands with HBV HCV prevalence rates above 2%. This study aimed reach for testing using point-of-care tests (POCT). A multifaceted strategy was employed aged ≥16 years from two Dutch municipalities free-of-charge HBsAg anti-HCV POCT finger prick blood at regional Public Health Service. All were personally invited by Service...
Understanding immunity from previous natural SARS-CoV-2 infection is important for booster vaccination strategies. A longitudinal study conducted in 2021 within the Meuse-Rhine Euroregion, bordering Netherlands, Belgium, and Germany, aimed to assess seroprevalence of spike-directed (anti-S) nucleocapsid-directed (anti-N) antibodies demonstrate as a result both (hybrid immunity), evaluate dynamics anti-N response. Questionnaires self-finger-prick blood samples 3110 participants were collected...
Few studies have been performed on urinary tract infections (UTIs) in men. In the present study, general practitioners (n = 42) from Dutch Sentinel General Practice Network collected samples 560 male patients (≥18 years) suspected of UTI and recorded prescribed antibiotic treatment. this way, susceptibility Gram-negative uropathogens, including extended-spectrum beta-lactamase (ESBL-) producing Escherichia coli could be determined. addition, E. prescriptions were compared with data a similar...
Abstract Background Day care centres (DCCs) are ideal settings for drug-resistant bacteria to emerge. Prevalence numbers of faecal carriage antimicrobial resistant in these rare. We aimed determine the prevalence children attending DCCs and assess identify infection risk factors within The Netherlands Belgium. Methods A point-prevalence study was conducted 28 Dutch (499 children) 18 Belgian (448 DCCs. Stool samples were taken from children’s diapers a questionnaire filled by their parents....
Over 90% of antibiotics for human use in Europe are prescribed primary care. We assessed the congruence between care treatment guidelines skin infections and commensal Staphylococcus aureus (S. aureus) antimicrobial resistance levels community-dwelling persons. The prevalence S. was analysed by taking nose swabs from healthy patients nine European countries (total N = 32,032). Primary bacterial were interpreted with respect to these patterns. First- second-choice recommendations considered...
To evaluate and compare Chlamydia trachomatis (CT) diagnostic test practices of different sexually transmitted infection (STI) care providers in 16-29 year olds from one defined geographic Dutch region (280,000 inhabitants). Both number proportion positive CT tests (ie, positivity) were assessed, factors associated with these outcomes.Data on laboratory testing diagnosis urogenital, anorectal oropharyngeal between 2006 2010 retrieved general practitioners (GPs), gynaecologists, an STI clinic...
Variant of concern (VOC) SARS-CoV-2 alpha variant (B.1.1.7) was the dominant strain in Netherlands between March 2021-June 2021. We describe three primary school outbreaks due to using whole genome sequencing with evidence large-scale transmission among children, teachers and their household contacts.All described were investigated by South Limburg Public Health Service, Netherlands. A case defined as an individual a real-time polymerase chain reaction test or antigen positive for...
Gonorrhoea, caused by Neisseria gonorrhoeae (NG), can cause reproductive morbidity, is increasingly becoming resistant to antibiotics and frequently asymptomatic, which shows the essential role of NG test practice. In this study we wanted compare diagnostic testing procedures between different STI care providers serving a defined geographic Dutch region (280,000 inhabitants).Data on laboratory diagnosis urogenital extragenital (i.e. anorectal oropharyngeal) were retrieved from general...
Abstract Background The Dutch province of Limburg borders the German district Heinsberg, which had a large cluster COVID-19 cases linked to local carnival activities before any were reported in Netherlands. However, Heinsberg was not included as an area reporting or community transmission per national case definition at time. In early March, two residents from long-term care facility (LTCF) Sittard, town located close vicinity tested positive for COVID-19. this study we aimed determine...
Breakthrough SARS-CoV-2 infections have been reported in fully vaccinated individuals, spite of the high efficacy currently available vaccines, proven trials and real-world studies. Several variants concern (VOC) proffered to be associated with breakthrough following immunization. In this study, we investigated 378 recorded between January July 2021 compared distribution genotypes identified 225 individuals frequency circulating community lineages region South Limburg (The Netherlands) a...
Abstract Background Since the Coronavirus Disease 2019 (COVID-19) pandemic, awareness of infection prevention and control (IPC) has increased in primary care settings. This study aimed to examine behavioural determinants shaping IPC behaviour pre-, during, post-pandemic among healthcare workers (HCWs) general practices, inform optimised care. Methods For this qualitative study, semi-structured in-depth interviews were conducted during two periods: (1) pre-COVID-19 pandemic: July...
For women with recurrent urinary tract infections (rUTI), the contribution of antibiotic use versus patient-related factors in determining presence antimicrobial resistance faecal and Escherichia coli, obtained from same patient population, has not been assessed yet. Within context 'Non-antibiotic prophylaxis for infections' (NAPRUTI) study, present study determinants E. coli isolated samples rUTIs collected at baseline. Potential were retrieved self-administered questionnaires. From 434...
Objective To assess health and activities of daily living (ADL) in SARS-CoV-2-positive adults with without post-COVID-19 condition (PCC) compare this negative tested individuals. Furthermore, different PCC case definitions were compared SARS-CoV-2-negative Methods All PCR positive for SARS-CoV-2 at the Public Health Service South Limburg (Netherlands) between June 2020 November 2021 (n=41 780) matched individuals (2:1, on age, sex, year-quarter test, municipality; n=19 875) invited by email....
Aim: The objective of this study is to compare various Streptococcus pneumoniae identification methods. Materials & methods: In total, 1371 putative S. isolates were tested with three phenotypic methods and a molecular-based method targeting virulence factor (CpsA). We assessed the sensitivity specificity each widely used algorithm. Results: None or algorithm separately was able correctly identify all isolates. Furthermore, high rate optochin resistance found. Conclusions: demonstrated...
Background Care institutions are recognised to be a high-risk setting for the emergence and spread of infections antimicrobial-resistant organisms, which stresses importance infection prevention control (IPC). Accurate implementation is crucial optimal IPC practice. Despite wide promotion research thereof in hospital nursing home setting, similar efforts lacking disability care settings. Therefore, this study aimed assess perceived barriers facilitators among professionals working at...