A5102801735- Lung Cancer Treatments and Mutations
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Colorectal Cancer Treatments and Studies
- Chronic Myeloid Leukemia Treatments
- Pelvic floor disorders treatments
- Biosimilars and Bioanalytical Methods
- Healthcare cost, quality, practices
- Chronic Lymphocytic Leukemia Research
- Cutaneous Melanoma Detection and Management
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Skin Protection and Aging
- Cancer Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- PI3K/AKT/mTOR signaling in cancer
- Pancreatic and Hepatic Oncology Research
- Nonmelanoma Skin Cancer Studies
- Cancer Genomics and Diagnostics
- Myofascial pain diagnosis and treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Lung Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
Pharmo Institute
2017-2023
Maastricht University
2019-2023
Utrecht University
2011-2023
Maastricht University Medical Centre
2019-2022
University Medical Center
2019-2022
Reimbursement decisions are conventionally based on evidence from randomised controlled trials (RCTs), which often have high internal validity but low external validity. Real-world data (RWD) may provide complimentary for relative effectiveness assessments (REAs) and cost-effectiveness (CEAs). This study examines whether RWD is incorporated in health technology assessment (HTA) of melanoma drugs by European HTA agencies, as well differences use between agencies across time. reports published...
A new method for quantification of osimertinib (OSIM) in human plasma using a high-performance liquid chromatography-tandem mass spectrometry was developed and validated. Methanol used protein precipitation pazopanib as internal standard. Separation performed on HyPURITY®C18 analytical column (50 × 2.1 mm; 3 μm) gradient elution ammonium acetate water methanol, both acidified with formic acid 0.1%. Detection OSIM triple quadruple spectrometer after electrospray ionization. This led to robust...
A liquid chromatography-tandem mass spectrometry method was developed and validated to quantify alectinib, crizotinib, erlotinib gefitinib. This assay can be combined with our for osimertinib, allowing quantification of the most used ALK- EGFR-tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer a single-assay setup. Chromatographic separation performed on HyPurity® C18 analytical column using an elution gradient ammonium acetate water methanol, both acidified formic acid 0.1%....
Abstract Osimertinib is prescribed to patients with metastatic non‐small cell lung cancer (NSCLC) and a sensitizing EGFR mutation. Limited data exists on the impact of patient characteristics or osimertinib exposure effectiveness outcomes. This was Dutch, multicenter cohort study. Eligible were ≥18 years, m + NSCLC, receiving osimertinib. Primary endpoint progression‐free survival (PFS). Secondary endpoints included overall (OS) safety. Kaplan‐Meier analyses multivariate Cox proportional...
Exposure to osimertinib, a third generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) for treatment of non-small cell lung cancer (NSCLC) and sensitizing EGFR mutation, can be substantially below average. We evaluated whether plasma levels could boosted by co-administration cobicistat, strong Cytochrome P450 3A-inhibitor.This was pharmacokinetic, proof-of-concept clinical trial (the OSIBOOST trial, NCT03858491). NSCLC-patients with osimertinib were eligible if...
Aim: We investigated the effectiveness of durvalumab post-concurrent CRT (cCRT) and post-sequential (sCRT) versus cCRT sCRT alone compared these outcomes with PACIFIC trial. Methods: Four cohorts stage III NSCLC patients who received were included: without durvalumab, durvalumab. PFS OS analyzed using Cox regression. Results: Durvalumab improved (cCRT: aHR = 0.69, sCRT: 0.71) 0.71, 0.32), although not all results significant. was longer in real-world than trial, while did differ. Conclusion:...
In- and exclusion criteria of randomized clinical trials (RCTs) aim to include a homogeneous study-population. This study compared characteristics lung cancer patients from phase III RCTs evaluating tyrosine kinase inhibitors (TKIs) or immune checkpoint (ICIs) with in real world setting the United Kingdom.A retrospective was conducted using Clinical Practice Research Datalink GOLD. Patients (N = 9239) first ever registration between 2014 2018 were identified. Eligibility for inclusion...
INTRODUCTION: Reimbursement decisions are usually based on evidence from randomized controlled trials (RCT) with high internal validity but lower external validity. Real-World Data (RWD) may provide complimentary for relative effectiveness assessments (REA's) and cost-effectiveness (CEA's) of treatments. This study explores to which extent RWD is incorporated in REA's CEA's drugs used treat metastatic melanoma (MM) by five Health Technology Assessment (HTA) agencies. METHODS: Dossiers MM...
Three-dimensional (3D) and four-dimensional (4D) volume transperineal ultrasound imaging is used to assess the axial plane of pelvic floor, including puborectalis muscle. This study was designed evaluate effect probe pressure women's perineum on Mean Echogenicity Puborectalis muscle (MEP), Muscle Area (PMA). a sub-analysis large prospective 3D/4D floor in primigravid women. To analyze applied pressure, datasets 15 women at 6 months postpartum were included. Volume data sets obtained with...
With three- and four-dimensional (3D/4D) volume transperineal ultrasound imaging we are able to visualise the puborectalis muscle in axial plane. Parameters like Mean Echogenicity of Puborectalis (MEP), Muscle Area (PMA) can be calculated. The goal this study is evaluate association between women's Body Mass Index (BMI), age sport activity on MEP PMA. This was a sub-analysis large prospective 3D/4D pelvic floor primigravid women, including datasets 105 primiparous women at 12 36 weeks...
Stress urinary incontinence (SUI) is a common condition in parous women, an increased prevalence already noticeable the first pregnancy. Although bladder neck mobility considered important factor SUI, underlying pathophysiology of SUI early pregnancy has not been fully elucidated. Therefore, aim this study was to compare and hiatal dimensions as assessed by transperineal ultrasound pregnant nulliparous women with without SUI. In prospective observational 280 were included trimester between...
INTRODUCTION: In 2007, the National Healthcare Institute (ZIN) initiated conditional financing (CF) of expensive hospital drugs as an example reimbursement schemes (CRS). CF is a 4-year procedure encompassing initial HTA assessment (T = 0) followed by additional data collection via outcomes research (separately assessing appropriate use & cost-effectiveness in routine practice) and re-assessment 4). This study aims to review performance experiences with Netherlands date. METHODS: All...