A5079564960- Peroxisome Proliferator-Activated Receptors
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
- Neuropeptides and Animal Physiology
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Biochemical and Molecular Research
- Drug Transport and Resistance Mechanisms
- Cancer Treatment and Pharmacology
- Microbial Metabolic Engineering and Bioproduction
- Chemical Synthesis and Analysis
- Diabetes Treatment and Management
- Circular RNAs in diseases
- Blood Coagulation and Thrombosis Mechanisms
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- Parkinson's Disease Mechanisms and Treatments
- Fungal and yeast genetics research
- Cellular transport and secretion
- Pharmacological Effects and Toxicity Studies
- Adipokines, Inflammation, and Metabolic Diseases
University of Southern Denmark
2014-2025
Odense University Hospital
2016-2025
John Wiley & Sons (United States)
2018
Hudson Institute
2018
PharmacoGenetics (China)
2013
University of Bologna
2011
National Institutes of Health
2006
National Human Genome Research Institute
2006
University of North Dakota
2006
Objective: Early and accurate diagnosis of prostate cancer (PC) is crucial for effective treatment. Diagnosing clinically insignificant cancers can lead to overdiagnosis overtreatment, highlighting the importance accurately selecting patients further evaluation based on improved risk prediction tools. Novel biomarkers offer promise enhancing this diagnostic process. In study, we aimed externally validate a previously developed urine plasma biomarker test in biopsy-naïve population. Materials...
In the present study, we show that depletion of acyl-CoA-binding protein, Acb1p, in yeast affects ceramide levels, protein trafficking, vacuole fusion and structure. Vacuoles Acb1p-depleted cells are multi-lobed, contain significantly less SNAREs (soluble N-ethylmaleimide-sensitive attachment receptors) Nyv1p, Vam3p Vti1p, unable to fuse vitro. Mass spectrometric analysis revealed a dramatic reduction content ceramides whole-cell lipids vacuoles isolated from cells. Maturation aminopeptidase...
Because α-synuclein (Snca) has a role in brain lipid metabolism, we determined the impact that loss of had on arachidonic acid (20:4n-6) metabolism vivo using Snca-/- mice. We measured [1-14C]20:4n-6 incorporation and turnover kinetics phospholipids an established steady-state kinetic model. Liver was used as negative control, no changes were observed between groups. In brains, there marked reduction 20:4n-6-CoA mass microsomal acyl-CoA synthetase (Acsl) activity toward 20:4n-6. Microsomal...
Abstract Previously, we demonstrated that ablation of α‐synuclein ( Snca ) reduces arachidonate (20:4n‐6) turnover in brain phospholipids through modulation an endoplasmic reticulum‐localized acyl‐CoA synthetase (Acsl). The effect on docosahexaenoic acid (22:6n‐3) metabolism is unknown. In the present study, examined gene 22:6n‐3 metabolism. We determined uptake and incorporation into by infusing awake, wild‐type −/− mice with [1‐ 14 C]22:6n‐3 using steady‐state kinetic modeling. addition,...
Background. Docetaxel is a highly effective treatment of wide range malignancies but often associated with peripheral neuropathy. The genetic variability genes involved in the transportation or metabolism docetaxel may be responsible for variation docetaxel-induced neuropathy (DIPN). main purpose this study was to investigate impact variants GSTP1 and ABCB1 on DIPN.Material methods. DNA extracted from whole blood 150 patients early-stage breast cancer who had received adjuvant February 2011...
The nuclear receptor peroxisome proliferator-activated gamma (PPAR gamma) is essential for adipogenesis. Although several fatty acids and their derivatives are known to bind activate PPAR gamma, the nature of endogenous ligand(s) promoting early stages adipocyte differentiation has remained enigmatic. Previously, we showed that lipoxygenase (LOX) activity involved in activation during differentiation. Of seven murine LOXs, only unconventional LOX epidermis-type 3 (eLOX3) expressed 3T3-L1...
In the present study, we have used DNA microarray and quantitative real-time PCR analysis to examine transcriptional changes that occur in response cellular depletion of yeast acyl-CoA-binding protein, Acb1p. Depletion Acb1p resulted differential expression genes encoding proteins involved fatty acid phospholipid synthesis (e.g. FAS1, FAS2, ACC1, OLE1, INO1 OPI3), glycolysis glycerol metabolism GPD1 TDH1), ion transport uptake ITR1 HNM1) stress HSP12, DDR2 CTT1). show transcription gene,...
Brown adipose tissue activity dissipates energy as heat, and there is evidence that lack of the retinoblastoma protein (pRb) may favor development brown adipocyte phenotype in cells. In this work we assessed impact germ line haploinsufficiency pRb gene (Rb) on response to high-fat diet feeding mice. Rb(+/-) mice had body weight adiposity indistinguishable from wild-type (Rb(+/+)) littermates when maintained a standard diet, yet they gained less fat after long-term coupled with reduced feed...
Our objective was to investigate the steady-state pharmacokinetic and pharmacodynamic interaction between antidepressive herbal medicine St John's wort antidiabetic drug metformin.We performed an open cross-over study in 20 healthy male subjects, who received 1 g of metformin twice daily for week with without 21 days preceding concomitant treatment wort. The pharmacokinetics determined, a 2 h oral glucose tolerance test performed.St decreased renal clearance but did not affect any other...
The aim of this study was to examine the effect single nucleotide polymorphisms in CYP2C8, LPIN1, PPARGC1A and PPARγ on rosiglitazone's (i) trough steady-state plasma concentration (C(ss,min)), (ii) glycosylated haemoglobin A1c (HbA1c) (iii) risk developing adverse events, mainly oedema, patients with type 2 diabetes mellitus (T2D).The data used were obtained from South Danish Diabetes Study including 371 T2D a focus 187 who treated rosiglitazone. placebo-controlled, partly blinded...
Abstract Background Factors such as age, gender, and genetic polymorphisms may explain individual differences in pain phenotype. Genetic associations with sensitivity have previously been investigated osteoarthritis patients, a focus on the P2X7, TRPV 1, TACR 1 genes. However, other genes play role well. Osteoarthritis is common joint disease, many patients suffering from this disease are thought to increased noxious stimuli resulting sensitization nociceptive system. The aim of study was...
Metformin is first-line treatment of type 2 diabetes mellitus and reduces cardiovascular events in patients with insulin resistance diabetes. Target tissue for metformin action thought to be the liver, where distribution depends on facilitated transport by polyspecific transmembrane organic cation transporters (OCTs). Non-alcoholic fatty liver disease (NAFLD) most common western world strong associations metabolic syndrome, but whether NAFLD affects biodistribution not known. In this study,...
Adipocyte differentiation is orchestrated by the ligand-activated nuclear receptor PPARγ. Endogenous ligands comprise oxidized derivatives of arachidonic acid and structurally similar PUFAs. Although expression PPARγ peaks in mature adipocytes, are produced primarily at onset differentiation. Concomitant with agonist production, murine fibroblasts undergo two rounds mitosis referred to as mitotic clonal expansion. Here we show that mouse embryonic deficient either cell cycle inhibitors,...
Sudden death due to acute intoxication occurs frequently in patients with opioid addiction (OA). To examine whether certain genotypes were associated this, we examined the frequencies of 29 SNPs located candidate genes related pharmacology: ABCB1, OPRM1, UGT2B7, CYP3A5, CYP2B6, CYP2C19, CYP2D6, COMT, KCNJ6 and SCN9A 274 deceased OA (DOA), 309 living (LOA) 394 healthy volunteers (HV). The main hypothesis study was that subjects homozygous for variant 3435T ABCB1 (rs1045642) occur more DOA...
Dysfibrinogenemia is a rare group of qualitative fibrinogen disorders caused by structural abnormalities in the molecule. The laboratory diagnosis dysfibrinogenemia controversial. Fibrinogen Paris V, clinically termed Dusart Syndrome, single base substitution gene coding for Aα-chain molecule.To diagnose first Scandinavian family with V affecting several members; proband, seven-year-old boy cerebral vein thrombosis.The was established following ISTH guideline testing supplemented fibrin...