A5007005415- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Sexual function and dysfunction studies
- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Urological Disorders and Treatments
- Hormonal and reproductive studies
- Testicular diseases and treatments
- Multiple and Secondary Primary Cancers
- Cardiac, Anesthesia and Surgical Outcomes
- Genital Health and Disease
- Tendon Structure and Treatment
- Renal and Vascular Pathologies
- Urinary Tract Infections Management
- Economic and Financial Impacts of Cancer
- Pelvic floor disorders treatments
- Global Cancer Incidence and Screening
- Sperm and Testicular Function
- Ureteral procedures and complications
- Surgical Simulation and Training
- MRI in cancer diagnosis
- Bone health and treatments
- Innovations in Medical Education
University of Southern Denmark
2016-2025
Odense University Hospital
2016-2025
Karolinska University Hospital
2014-2025
Karolinska Institutet
2015-2025
Steno Diabetes Centers
2025
Aarhus University Hospital
1997-2024
Aalborg University Hospital
1990-2024
Regionshospitalet Viborg
2005-2023
University of Copenhagen
1997-2023
Aalborg University
2016-2023
von Hippel Lindau disease (vHL) is caused by a hereditary predisposition to multiple neoplasms, especially hemangioblastomas in the retina and CNS, renal cell carcinomas (RCC), pheochromocytomas, neuroendocrine pancreatic tumours (PNET) endolymphatic sac tumours. Evidence based approaches are needed ensure an optimal clinical care, while minimizing burden for patients their families. This guideline on evidence from international vHL literature extensive research of geno- phenotypic...
Abstract Background Primary tumor removal by cytoreductive nephrectomy in synchronous metastatic renal cell carcinoma patients has been investigated the context of various treatment regimens. Two randomized controlled trials role and timing era targeted therapy demonstrated that upfront should no longer be performed when require systemic therapy. Superiority checkpoint immunotherapy agents led to a paradigm change from therapies immunotherapy-based first-line with primary disease; thus,...
The aim of this study was to investigate whether low-intensity extracorporeal shockwave therapy (LI-ESWT) can be used as a treatment for men with erectile dysfunction organic origin.This prospective, randomized, blinded, placebo-controlled included 112 unable have intercourse either or without medication. Erectile assessed at screening and 5, 12 24 weeks after treatment. Assessment performed by interview using the Erection Hardness Scale (EHS) International Index Function (IIEF-15)...
Abstract Aim This study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications. Methods Danish nationwide was conducted among incident cases diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE), myocarditis, and atrial fibrillation (AF), between January 2000 December 2022. Using case‐crossover design, we examined exposure individual drugs on the date event (focal date)...
Background Natural language processing models are increasingly used in scientific research, and their ability to perform various tasks the research process is rapidly advancing. This study aims investigate whether Generative Pre-trained Transformer 4 (GPT-4) equal humans writing introduction sections for articles. Methods randomized non-inferiority was reported according Consolidated Standards of Reporting Trials trials artificial intelligence (AI) guidelines. GPT-4 instructed synthesize 18...
Age is the strongest risk factor for developing cancer. The aim of present analysis to give an overview trends in cancer incidence, mortality, prevalence, and relative survival Denmark from 1980 2012 focusing on age, comparing persons aged 70 years or more with those less than years.Data derived NORDCAN database comparable data prevalence Nordic countries. Danish originate Cancer Registry Cause Death follow-up death emigration until end 2013.Incidence mortality rates all sites, but...
To evaluate the Bone Scan Index (BSI) for prediction of castration resistance and prostate cancer-specific survival (PCSS). In this retrospective study, we used novel computer-assisted software automated detection/quantification bone metastases by BSI. Patients with cancer are M-staged whole-body scintigraphy (WBS) categorised as M0 or M1. Within M1 group, there is a wide range clinical outcomes. The BSI was introduced decade ago providing quantification estimating percentage involvement....
Objective: To investigate the efficacy of extracorporeal shockwave therapy (ESWT) on healing chronic diabetic foot ulcers (DFU). Method: Patients with DFUs were randomised (1:1) to receive a series six ESWT treatments over 3 weeks in combination standard care or alone. was performed using 250 shocks/cm 2 and 500 shocks arterial beds supplying ulcer location. Results: We recruited 23 patients, 11 intervention group 12 control. Transcutaneous oxygen tension significantly increased patients...
Urinary tract infection (UTI) is the most common bacterial infectious disease with a high frequency of recurrence and leading cause septicemia. In vivo experimentation has contributed significantly to present-day knowledge on urinary pathogenesis. This research traditionally almost exclusively been based murine models UTI. Conflicting results between UTI in mice humans increasing skepticism towards small rodent general warrant need novel large-animal that better resemble anatomy physiology...
To assess the safety of computed tomography-guided percutaneous cryoablation (PCA) in patients who had pre-procedural ureteral stenting, while they were treated for clinical T1 renal cell carcinoma (RCC) with complex location. This retrospective international multicenter cohort study included between January 2016 and February 2021 at two University Hospitals, X1 X2. Patients aged more than 18 years suspected RCC included. All underwent stenting. The complications recorded within 30 days...
Objective: Early and accurate diagnosis of prostate cancer (PC) is crucial for effective treatment. Diagnosing clinically insignificant cancers can lead to overdiagnosis overtreatment, highlighting the importance accurately selecting patients further evaluation based on improved risk prediction tools. Novel biomarkers offer promise enhancing this diagnostic process. In study, we aimed externally validate a previously developed urine plasma biomarker test in biopsy-naïve population. Materials...
Background Birt-Hogg-Dubé syndrome (BHD), a rare genetic disease characterized by multiple pulmonary cysts, can lead to spontaneous pneumothorax, cutaneous hamartomas, renal and cell cancer. The overall aim of this study was assess clinical characteristics patients with BHD-emphasizing on trends in function patterns.
Abstract Background The diagnosis of pulmonary hypertension (PH) relies on measuring artery pressures at right heart catheterization (RHC). Echocardiographic tricuspid regurgitation velocity (TRV) is a screening tool to define PH probability. While latest guidelines reduced RHC threshold for diagnosis, TRV thresholds were not. We aimed update probability according the novel criteria. Methods Patients undergoing suspected prospectively enrolled. A retrospective cohort was used external...
Abstract Purpose Low-intensity extracorporeal shockwave therapy (LI-ESWT) is a potential novel treatment against diabetic kidney disease (DKD). The present study investigates the longer term effects of LI-ESWT on function in patients with DKD. Methods This matched cohort included 28 DKD, who received six sessions LI-ESWT. Patients were 1:5 from Funen Diabetes Database. Multivariable adjusted eGFR and ACR analyzed using multilevel mixed-effects linear regression. primary outcomes measured at...
Adipose-derived regenerative cells (ADRCs) also referred to as the stromal vascular fraction, provide an ample source of stem with widespread therapeutic use. Being heterogenous in nature, possibly affecting clinical outcome after cell treatment, ADRC- donor, -BMI, and -gender may have a large impact on ADRC composition quality but this remains largely unexplored. Herein, we comprehensive single-cell RNA sequencing mapping across two trial intervention studies found no gender- or BMI-related...
Summary Aim To test the feasibility of a fully automated artificial intelligence‐based method providing PET measures prostate cancer ( PC a). Methods A convolutional neural network CNN ) was trained for measurements in 18 F‐choline FCH / CT scans obtained prior to radical prostatectomy RP 45 patients with newly diagnosed a. Automated values were volume, maximal standardized uptake value SUV max ), mean voxels considered abnormal and volume (Vol abn ). The product × Vol calculated reflect...
Evidence-practice gaps exist in urology. We previously surveyed European Association of Urology (EAU) guidelines for strong recommendations underpinned by high-certainty evidence that impact patient experience which practice variations were suspected. The recommendation "Do not offer neoadjuvant androgen deprivation therapy (ADT) before surgery patients with prostate cancer" was prioritised further investigation. ADT is neither clinically effective nor cost and has serious side effects....