A5086363858- Xenotransplantation and immune response
- Anesthesia and Pain Management
- Organ Transplantation Techniques and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Animal Genetics and Reproduction
- Hemodynamic Monitoring and Therapy
- Pain Management and Opioid Use
- Cardiac Ischemia and Reperfusion
- Pain Mechanisms and Treatments
- Virus-based gene therapy research
- Musculoskeletal pain and rehabilitation
- Total Knee Arthroplasty Outcomes
- Tissue Engineering and Regenerative Medicine
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- Cardiovascular Syncope and Autonomic Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Blood transfusion and management
- Neuropeptides and Animal Physiology
- Biomedical and Chemical Research
- Non-Invasive Vital Sign Monitoring
- Nausea and vomiting management
- Heart Rate Variability and Autonomic Control
- Pain Management and Placebo Effect
- Liver physiology and pathology
Hannoversche Kinderheilanstalt
2023
Medizinische Hochschule Hannover
2000-2022
DIAKO
2020-2021
Francis Hospital
2015
Thrombosis and Atherosclerosis Research Institute
2015
Diakonissenkrankenhaus
2012-2014
The Royal Free Hospital
2001
University College London
2001
Hannover Re (Germany)
2001
Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin
2000
Previous studies show a prolongation of activated partial thromboplastin time and prothrombin in healthy volunteers after treatment with sugammadex. The authors investigated the effect sugammadex on postsurgical bleeding coagulation variables.This randomized, double-blind trial enrolled patients receiving thromboprophylaxis undergoing hip or knee joint replacement fracture surgery. Patients received 4 mg/kg usual care (neostigmine spontaneous recovery) for reversal rocuronium-...
Opioids are often used for pain treatment, but the response is insufficient and dependent on e.g. condition, genetic factors drug class. Thus, there an urgent need to identify biomarkers enable selection of appropriate individual patient, a concept known as personalized medicine. Quantitative sensory testing (QST) clinical parameters can provide some guidance response, better more objective urgently warranted. Electroencephalography (EEG) may be suitable since it assesses central nervous...
The development of persistent postoperative pain may occur following surgery, including total hip replacement. Yet, the prevalence depend on definition pain. This observational cohort study explored whether after replacement differs depending and evaluated impact ongoing patient's quality life 6 months surgery.Pre- characteristics 125 patients undergoing elective were assessed 104 available for follow-up interview, surgery.Six between 26% 58% still reported - Patients with moderate-to-severe...
Pre-existing or chronic pain is an established risk factor for severe postoperative pain. In this prospective observational cohort study, we investigated whether a history of pain, beyond the presence hip-related affected other factors including early mobilization, function, and psychological distress after hip surgery. Patients who underwent total replacement surgery were observed from preoperative day until seventh day. Before surgery, they characterized by their history, intensity,...
Abstract: The introduction of h‐DAF transgenic porcine organs into pre‐clinical pig‐to‐primate discordant xenotransplantation has led to complete and reliable abrogation hyperacute xenograft rejection (HAR). Despite additional heavy immunosuppression however, most xenografts are still lost due acute vascular (AVR), with current treatment protocols being only limited value. In a life‐supporting model kidney transplantation, unmodified (n = 8) or h‐DAF‐transgenic 9) kidneys were transplanted...
Abstract Background Factors such as age, gender, and genetic polymorphisms may explain individual differences in pain phenotype. Genetic associations with sensitivity have previously been investigated osteoarthritis patients, a focus on the P2X7, TRPV 1, TACR 1 genes. However, other genes play role well. Osteoarthritis is common joint disease, many patients suffering from this disease are thought to increased noxious stimuli resulting sensitization nociceptive system. The aim of study was...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Moreno IT, Tsamassiottis S, Ettinger M, Fischer-Kumbruch Przemeck M. Femoral nerve blockade versus local infiltration analgesia for primary knee arthroplasty. Randomised controlled trial. Anaesthesiology Intensive Therapy. 2022;54(5):387-392. doi:10.5114/ait.2022.123346. APA Moreno, I. T., Tsamassiottis, S., Ettinger, M., Fischer-Kumbruch, & Przemeck, (2022). Therapy, 54(5), 387-392....
Abstract: At present, the major barrier to successful discordant xenotransplantation of unmodified or complement regulator transgenic porcine xenografts is acute vascular xenograft rejection (AVR). AVR associated with intragraft deposition induced recipient xenoreactive antibodies and subsequent activation. In a life‐supporting pig primate kidney setting using h‐DAF donor organs postoperative immunosuppression, episodes were either treated boluses cyclophosphamide steroids same regimen...
Background: Pulse‐contour analysis represents a technique for cardiac output (CO)‐measurement and allows continuously monitoring trends in CO. We evaluated reliability of pulse‐contour CO (COpc) septic shock. Methods: Seventeen anaesthetized mechanically ventilated pigs were investigated. After baseline measurements, 14 animals received 0.75 g/kg body weight faeces into the abdominal cavity to induce sepsis observed over 9 h, three served as controls. A central venous catheter was inserted...
Experimental models have been used extensively to evaluate pain using e.g., visual analogue scales or electroencephalography (EEG). Stimulation tonic has shown better mimic the unpleasantness of chronic pain, but mainly evoked by non-clinical stimuli. This study aims to, EEG during clinical in patients scheduled for total hip replacement with control and resting conditions.The was moved examiner evoke 30 seconds while recording EEG. The condition entailed movement opposite a similar fashion...
Organs transplanted between phylogenetically disparate species, such as from the pig into primate, are subject to hyperacute rejection (HAR). This form of xenograft is mediated by preformed natural antibodies and believed occur invariably in discordant xenografts thus leading rapid destruction complete thrombosis graft. Recent data, however, have shown that porcine cynomolgus monkey setting, HAR not inevitably seen after kidney transplantation. The influence preoperative antiporcine antibody...
Emerging evidence highlights the importance of preoperative expectations in predicting patient-reported outcomes orthopedic surgeries. To date, it is still a matter controversy whether patient satisfaction can be maximized by promoting either optimistic or realistic outcome before surgery. Adjusting overly expectancies favor more outlook on limitations total hip arthroplasty could reduce risk disappointment and lead to greater with surgery outcomes. Our prospective cohort study was aimed at...
Rahe-Meyer, Niels; Fennema, Hein; Schulman, Sam; Klimscha, Walter; Przemeck, Michael; Blobner, Manfred; Wulf, Hinnerk; Speek, Marcel; Sisk, Christine McCrary; Williams-Herman, Debora; Woo, Tiffany; Szegedi, Armin Author Information
BACKGROUND: Current literature about the effects of patients' expectations on relevant outcome measures is still conflicting and incomplete. The aim this prospective observational study was to assess influence fulfillment postoperative pain intensity relief. Furthermore, clinical characteristics influencing were explored.METHODS: Patients undergoing elective orthopedic surgery assessed using two standardized self-report questionnaires day before third day. One hundred seventy patients from...
Abstract Background Sympathomimetic drugs are a therapeutic cornerstone for the management of hypotensive states like intraoperative hypotension (IOH). While cafedrine/theodrenaline (C/T) is widely used in Germany to restore blood pressure patients with IOH, more research required compare its effectiveness alternatives such as ephedrine (E) that commonly available internationally. Methods HYPOTENS (NCT02893241, DRKS00010740) was prospective, national, multicenter, open-label, two-armed,...
After xenograft reperfusion, complement activation may lead to generation of anaphylatoxins and cardiocirculatory instability the recipient.In 13 cynomolgus recipients either unmodified or human decay accelerating factor transgenic porcine kidneys parameters were measured by single indicator transpulmonary thermodilution.After graft recipient cardiac output decreased 25.4% (P<0.05), intrathoracic blood volume 22.8% extravascular lung water increased slightly (P=n.s.). The impairment in was...
Abstract: We here describe the identification of new allele HLA‐B*4431, which was found in three members a Turkish family. Sequencing following haplotype‐specific PCR amplification revealed that exon 2 is identical to HLA‐B*4402, whereas 3 resembles HLA‐B*40 variant with exception position 572, where single nucleotide transversion (C > G) leads an amino acid exchange (Trp162Ser). The generation 3′ part B*4431 may be best explained by separate recombination between B*40 and B*07. Although...