A5088770887- Forensic Toxicology and Drug Analysis
- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Cannabis and Cannabinoid Research
- Education, Healthcare and Sociology Research
- Analytical Chemistry and Chromatography
- Pharmacogenetics and Drug Metabolism
- Pancreatic function and diabetes
- Poisoning and overdose treatments
- Pharmacological Effects and Toxicity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Restraint-Related Deaths
- Diet and metabolism studies
- Crime, Illicit Activities, and Governance
- Neurosurgical Procedures and Complications
- Forensic Fingerprint Detection Methods
- Prenatal Substance Exposure Effects
- Neuropeptides and Animal Physiology
- Eicosanoids and Hypertension Pharmacology
- Drug Transport and Resistance Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Migration, Health and Trauma
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Diabetes Treatment and Management
University of Southern Denmark
2015-2023
Institute of Forensic Science
2015
<b><i>Background/Aims:</i></b> Increasing rates of overdose deaths involving opioid maintenance treatment (OMT) medications and particularly methadone have been observed concurrently with the implementation liberal OMT strategies (i.e. minimum control high doses prescribed). This study examined methadone-related in a programme. <b><i>Methods:</i></b> Drug-overdose (n = 130) detection Copenhagen, Aarhus, Odense Municipality, Denmark, during...
Sudden death due to acute intoxication occurs frequently in patients with opioid addiction (OA). To examine whether certain genotypes were associated this, we examined the frequencies of 29 SNPs located candidate genes related pharmacology: ABCB1, OPRM1, UGT2B7, CYP3A5, CYP2B6, CYP2C19, CYP2D6, COMT, KCNJ6 and SCN9A 274 deceased OA (DOA), 309 living (LOA) 394 healthy volunteers (HV). The main hypothesis study was that subjects homozygous for variant 3435T ABCB1 (rs1045642) occur more DOA...
Abstract Patients suffering from psychiatric disorders have an excess mortality and a shorter life span expectancy compared to the general population. Furthermore, they are treated with multiple drugs known increased risk of drug abuse. In this study, we aimed at investigating pharmaceutical abuse profiles deceased included in Danish prospective autopsy‐based forensic study on patients, SURVIVE. Using postmortem systematic toxicological analysis results, identified 129 different consumed...
Objective: The objectives of the study were to describe distribution tetrahydrocannabinol (THC)-influenced drivers in a new Danish 3-level offense system and discuss consequences changed legislation.Methods: By request police, blood individuals suspected driving under influence drugs (DUID) Funen Southern Jutland was sampled by medical staff shipped Section Forensic Toxicology University Denmark Odense. Samples from for cannabis (DUIC) stored at 5 °C prior immediate analysis, THC content...
Intracranial pressure (ICP) monitoring at our department includes a standardized postural change examination to evaluate its effects on ICP. During these procedures we observed that neck flexion caused an increase in ICP one patient. To clarify if the observation was random occurrence or it could be reproduced, added and extension standard examination.
Quantitative results from toxicological analyses of autopsy material are widely compared to ranges in reference works determine if drug concentrations relevant levels for establishing intoxication. This study compares commonly used opioids and stimulants addict autopsies driving under the influence drugs (DUID) cases supplement current knowledge possible span overlaps measured concentrations. The included whole-blood forensic addicts performed 2015 2020 (n = 220) DUID 2019 7088). focus was...
An analytical procedure is presented which determines benzene, toluene, ethylbenzene and total aromatics in non-olefinic hydrocarbon solvents boil between 100 450°F. This compositional information required connection with current air pollution laws. The method based on (a) the addition of a known amount internal standard (hexamethylbenzene), (b) segregation aromatic hydrocarbons sample by liquid chromatography silica, (c) analysis this fraction (plus solvent) gas chromatography. applicable...