A5056860421- Growth Hormone and Insulin-like Growth Factors
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Heart Failure Treatment and Management
- Diabetes Management and Research
- Regulation of Appetite and Obesity
- Lipid metabolism and disorders
- Pituitary Gland Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Nutrition and Health in Aging
- Colorectal Cancer Screening and Detection
- Metabolism and Genetic Disorders
- Adrenal Hormones and Disorders
- Hormonal and reproductive studies
- Cardiovascular and exercise physiology
- Advanced MRI Techniques and Applications
- Body Composition Measurement Techniques
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Thyroid Disorders and Treatments
Aarhus University
1994-2024
Aarhus University Hospital
2006-2020
Regionshospitalet Viborg
2008-2013
Philips (United States)
2013
IPS Research (United States)
2013
Aarhus Municipality
1998-2003
Mayo Clinic
2001
WinnMed
2001
Diabetes Australia
1999
Hvidovre Hospital
1998
The incretin hormone glucagon-like peptide-1 (GLP-1) and its analogs are currently emerging as antidiabetic medications. GLP-1 improves left ventricular ejection fraction (LVEF) in dogs with heart failure (HF) patients acute myocardial infarction. We studied metabolic cardiovascular effects of 48-h infusions congestive HF. In a randomized, double-blind crossover design, 20 without diabetes HF ischemic disease, EF 30 ± 2%, New York Heart Association II III ( n = 14 6) received (0.7 pmol·kg −1...
Summary objective Ghrelin was recently identified as a specific endogenous ligand for the growth hormone secretagogue receptor (GHS‐R). This new isolated from rat and human stomach reported to circulate in plasma, but regulation physiological significance of ghrelin humans have not been clarified. The present study undertaken test following hypotheses: (1) prolonged fasting, which is known stimulate GH secretion, associated with changes immunoreactivity; (2) somatostatin systemic circulation...
The kidney is probably critically involved in the development of essential hypertension, as many genetic models hypertension. We have investigated whether a narrowed renal afferent arteriole pathogenesis hypertension spontaneously hypertensive rats. Systolic blood pressure 37 F2 generation rats/Wistar-Kyoto rats was measured at age 7 weeks. right removed, and lumen diameter media cross-sectional area arterioles were after having been fixed while relaxed under transmural 100 mm Hg....
We investigated the association of early achieved HbA1c level and magnitude reduction with subsequent risk cardiovascular events or death in patients type 2 diabetes who initiate metformin.This was a population-based cohort study including all metformin initiators tests Northern Denmark, 2000-2012. Six months after initiation, we classified by (<6.5% higher) change from pretreatment baseline. used Cox regression to examine rates acute myocardial infarction, stroke, death, controlling for...
Abstract. Objective. It is well known that chronic heart failure (CHF) associated with insulin resistance and cachexia, but little about the underlying substrate metabolism. The present study was undertaken to identify disturbances of basal glucose, lipid protein Design. We studied eight nondiabetic patients CHF (ejection fraction 30 ± 4%) healthy controls. Protein metabolism (whole body regional muscle fluxes) total glucose turnover were isotopically assayed. Substrate oxidation obtained by...
The metabolic response to fasting involves a series of hormonal and adaptations leading protein conservation. An increase in the serum level growth hormone (GH) during has been well substantiated. present study was designed test hypothesis that GH may be principal mediator conservation assess underlying mechanisms. Eight normal subjects were examined on four occasions: 1) basal postabsorptive state (basal), 2) after 40 h (fast), 3) with somatostatin suppression (fast-GH), 4) exogenous...
Hyperthyroidism is characterized by increased levels of circulating free fatty acids (FFA) and lipid oxidation, but it uncertain which regional fat depots contribute. The present study was designed to define the participation femoral abdominal stores in overall stimulation lipolysis hyperthyroidism basal state during insulin stimulation.
Abstract The appropriate management of GH-deficient patients during transition from childhood to adulthood has not been reported in controlled trials, even though there is evidence suggest that this phase associated with specific problems relation GH sensitivity. An issue particular interest the impact substitution on insulin sensitivity, which normally declines puberty. We, therefore, evaluated sensitivity (euglycemic glucose clamp) and substrate metabolism 18 (6 females 12 males; age, 20 ±...
During fasting, a lack of GH increases protein loss by close to 50%, but the underlying mechanisms remain uncertain. The present study tests hypothesis that anabolic actions depend on mobilization lipids. Seven normal subjects were examined four occasions during 37-h fast with infusion somatostatin, insulin, and glucagon for final 15 h: 1) replacement, 2) replacement antilipolysis acipimox, 3) without antilipolysis, 4) intralipid. Urinary urea excretion, serum concentrations, muscle...
Thyroid hormones have significant metabolic effects, and muscle wasting weakness are prominent clinical features of chronic hyperthyroidism. To assess the underlying mechanisms, we examined seven hyperthyroid women with Graves' disease before (Ht) after (Eut) medical treatment control subjects (Ctr). All underwent a 3-h study in postabsorptive state. After regional catheterization, protein dynamics whole body forearm muscles were measured by amino acid tracer dilution technique using [ 15...
Aim To examine real‐life time trends in early glycaemic control patients with type 2 diabetes between 2000 and 2012. Methods We used population‐based medical databases to ascertain the association achievement of initial glucose‐lowering treatment incident N orthern D enmark. Success reaching glycated haemoglobin ( HbA1c ) goals within 3–6 months was examined using regression analysis. Results Of 38 418 patients, 91% started oral drugs monotherapy. Metformin initiation increased from 32%...
Background Skeletal muscle wasting is critical in patients with heart failure (HF). Whereas prior studies have employed appendicular lean mass (ALM) normalized by height squared to identify low skeletal mass, the potential of ALM body index (ALM/BMI) remains unexplored HF. In this study, we compared use 2 indices HF examine their sex‐specific correlations measures physical capacity, quality life, and daily activity. Methods Results A total 111 underwent dual x‐ray absorptiometry, capacity...
GH and other stress hormones stimulate lipolysis, which may result in free fatty acid (FFA)-mediated insulin resistance. However, there are also indications that FFAs the very low physiological range have same effect.The objective of study was to address systematically dose-response relations between sensitivity.We therefore examined eight healthy men for 8 h (6 basal 2 glucose clamp) on four occasions.Intralipid infused at varying rates (0, 3, 6, 12 microl.kg(-1).min(-1)); lipolysis blocked...
Whether GH promotes IGF-I production or lipolysis depends on nutritional status, but the underlying mechanisms remain unknown.To investigate impact of fasting GH-mediated changes in substrate metabolism, insulin sensitivity, and signaling pathways.We conducted a randomized crossover study.Ten healthy men (age 24.3 +/- 0.6 yr, body mass index 23.1 0.4 kg/m(2)) participated.A bolus administered 1) postabsorptively 2) state (37.5 h). Skeletal muscle adipose tissue biopsies were taken,...
Context: Experimental studies in GH-deficient patients and healthy subjects receiving somatostatin-infusion suggest that GH is an important regulator of substrate metabolism during fasting. These models may not adequately reflect the selective effects GH, receptor (GHR) blockade offers a new model to define metabolic role GH. Objective: The aim this study was investigate impact GHR on insulin sensitivity Design: We conducted randomized, placebo-controlled, crossover 10 young men....
Circulating free fatty acids (FFAs) may worsen heart failure (HF) due to myocardial lipotoxicity and impaired energy generation. We studied cardiac whole body effects of 28 days suppression circulating FFAs with acipimox in patients chronic HF. In a randomized double-blind crossover design, 24 HF ischemic disease [left ventricular ejection fraction: 26 ± 2%; New York Heart Association classes II (n = 13) III 5)] received treatment (250 mg, 4 times/day) placebo. Left fraction, diastolic...
OBJECTIVE Development of muscle weakness and atrophy are well known complications thyrotoxicosis, although little is about its clinical course. The present longitudinal study was therefore undertaken to monitor mass strength before during treatment hyperthyroidism. DESIGN AND PATIENTS Five patients (2 male, 3 female; Age 41 ± 6 years; BMI 22.2 1.1 kg/m 2 ) with newly diagnosed hyperthyroidism were studied respect area, strength, body composition substrate metabolism at baseline after 1, 3,...
Lower gastrointestinal (GI) bleeding is a well-known symptom of colorectal cancer (CRC). Whether incident GI also marker other cancers remains unclear.This nationwide cohort study examined the risk various types in patients with lower bleeding. We used Danish medical registries to identify all first-time hospital diagnosis during 1995-2011 and followed them for 10 years subsequent diagnoses. computed absolute risks cancer, treating death as competing risk, calculated standardized incidence...