A5075684889- Retinal Development and Disorders
- Schizophrenia research and treatment
- Retinal Diseases and Treatments
- Mental Health and Psychiatry
- Bipolar Disorder and Treatment
- Retinal and Optic Conditions
- Posttraumatic Stress Disorder Research
- Resilience and Mental Health
- Glaucoma and retinal disorders
- Child and Adolescent Psychosocial and Emotional Development
- Cell Adhesion Molecules Research
- Family Caregiving in Mental Illness
- Cellular transport and secretion
- Migration, Health and Trauma
- Mental Health Treatment and Access
- Connexins and lens biology
- Psychosomatic Disorders and Their Treatments
- Photoreceptor and optogenetics research
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Visual Impairment Studies
- Viral Infections and Immunology Research
- Psychiatric care and mental health services
- Genetic Syndromes and Imprinting
- melanin and skin pigmentation
- Intraocular Surgery and Lenses
Copenhagen University Hospital
2009-2025
Rigshospitalet
2010-2025
Kennedy Center
2012-2022
Glostrup Hospital
2012-2021
University of Copenhagen
1993-2021
The Danish Veteran Centre
2013-2016
Danish Gas Technology Centre (Denmark)
2013-2014
Mental Health Services
2008-2014
Capital Region of Denmark
2008-2014
Hudklinikken
2013
Intensive early treatment for first-episode psychosis has been shown to be effective. It is unknown if the positive effects are sustained 5 years.To determine long-term of an intensive early-intervention program (OPUS) psychotic patients.Single-blinded, randomized, controlled clinical trial 2 years vs standard treatment. Follow-up periods were and years.Copenhagen Hospital Corporation Psychiatric Hospital, Aarhus, Denmark. Patients A total 547 patients with a first episode psychosis. Of...
In the study reported here, we examined posttraumatic stress disorder (PTSD) symptoms in 746 Danish soldiers measured on five occasions before, during, and after deployment to Afghanistan. Using latent class growth analysis, identified six trajectories of change PTSD symptoms. Two resilient had low levels across all times, a new-onset trajectory started showed marked increase Three temporary-benefit trajectories, not previously described literature, decreases during (or immediately after)...
Those with first-episode psychosis are at high-risk of suicide.To identify predictive factors for suicidal thoughts, plans and attempts, to investigate the rate suicides other deaths during 5 years after first diagnosis initiation treatment.A longitudinal, prospective, 5-year follow-up study 547 individuals schizophrenia spectrum psychosis. Individuals presenting their treatment in mental health services two circumscribed urban areas Denmark were included a randomised controlled trial...
Autosomal recessive Stargardt disease (STGD1, MIM 248200) is caused by mutations in the ABCA4 gene. Complete sequencing of STGD patients identifies compound heterozygous or homozygous disease-associated alleles 65–70% and only one mutation 15–20% patients. This study was designed to find missing disease-causing variation a combination next-generation (NGS), array-Comparative Genome Hybridization (aCGH) screening, familial segregation silico analyses. The entire 140 kb genomic locus sequenced...
Gender differences in psychosis have been investigated, and the results contributed to a better understanding of disease, but many questions are unanswered. In clinical terms, women men with differ terms access social support, tendency substance abuse, level functioning symptom patterns. We aimed investigate how gender at onset develop during first 5years treatment.A total 578 patients first-episode schizophrenia spectrum were included Danish OPUS trial--a randomized trial comparing 2 years...
Information about the cost-effectiveness of early intervention programmes for first-episode psychosis is limited.To evaluate an intensive early-intervention programme (called OPUS) (trial registration NCT00157313) consisting enriched assertive community treatment, psychoeducational family treatment and social skills training individuals with compared standard treatment.An incremental analysis a randomised controlled trial, adopting public sector perspective was undertaken.The mean total...
Abstract Inherited retinal diseases (IRDs) are a common cause of visual impairment. IRD covers set genetically highly heterogeneous disorders with more than 150 genes associated one or clinical forms IRD. Molecular genetic diagnosis has become increasingly important especially due to expanding number gene therapy strategies under development. Next generation sequencing (NGS) panels proven valuable diagnostic tool in We present the molecular findings 677 individuals, residing Denmark, and...
Abstract Background The early phases of psychosis have been hypothesized to constitute a critical period, window opportunity. At the same time, are associated with increased risk unwanted outcome, such as suicidal behaviour and social isolation. This was background for emergence intervention services, in D enmark, OPUS trial initiated part that process. Methods Modified assertive community treatment, together family involvement skills training, constituted core elements original programme. A...
Article AbstractObjective: To identify trajectories of posttraumatic stress disorder (PTSD) symptoms from before to 2.5 years after deployment and assess risk factors for symptom fluctuations late-onset PTSD.Method: 743 soldiers deployed Afghanistan in 2009 were assessed PTSD using the Checklist (PCL) at 6 occasions predeployment postdeployment (study sample = 561). Predeployment vulnerabilities stressors also assessed.Results: Six identified: a resilient trajectory with low levels across...
<b>Objectives</b> To evaluate comorbidity before and after the diagnosis of branch retinal vein occlusion to determine whether it is a consequence arterial thickening therefore could serve as diagnostic marker for other comorbidities risk factors development such occlusion. <b>Design</b> Case-control study with prospective follow-up data from Danish national registries. <b>Setting</b> Four secondary referral centres covering about 80% population (4.4 million). <b>Participants</b> 1168...
Autosomal recessive Stargardt disease (STGD1, MIM 248200) is caused by mutations in the ABCA4 gene. Complete sequencing of locus STGD1 patients identifies two expected disease-causing alleles ∼75% and only one mutation ∼15% patients. Recently, many possibly pathogenic variants deep intronic sequences have been identified latter group. We extended our analyses determined that these, c.4253+43G>A (rs61754045), present 29/1155 (2.6%) The variant found at statistically significantly higher...
Background Several studies indicate that cannabis use among patients with psychotic disorders is associated worse outcome, but only a few have controlled for baseline condition and medication. Method At 5-year follow-up, interviews were carried out 314 first-episode psychosis included in the OPUS trial. The age range of 18 to 45 years old 59% male. Cannabis was extracted from Schedule Clinical Assessment Neuropsychiatry. divided into different groups according variable use: abstainers,...
Purpose: Generalized retinal dystrophy is a frequent cause of visual impairment and blindness in younger individuals subject new clinical intervention trials. Nonetheless, there are few nation-wide population-based epidemiological data generalized dystrophy. The purpose this study was to examine the prevalence diagnostic spectrum Danish population.Methods: A cross-sectional with from Retinitis Pigmentosa Registry that comprises all patients Denmark chorioretinal dystrophies 19th century...