A5005253964- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Hemoglobinopathies and Related Disorders
- Heart Rate Variability and Autonomic Control
- Neuroscience and Neuropharmacology Research
- Long-Term Effects of COVID-19
- Autoimmune Bullous Skin Diseases
- Advanced MRI Techniques and Applications
- Bipolar Disorder and Treatment
- Peripheral Neuropathies and Disorders
- Urticaria and Related Conditions
- Cardiac electrophysiology and arrhythmias
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neural dynamics and brain function
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Older Adults Driving Studies
- Neonatal and fetal brain pathology
- Clinical Reasoning and Diagnostic Skills
- Bacterial Infections and Vaccines
- Innovations in Medical Education
- Autoimmune Neurological Disorders and Treatments
- Myasthenia Gravis and Thymoma
University of Oulu
2014-2024
Oulu University Hospital
1998-2022
Urho Kaleva Kekkonen Institute
2014
University of Helsinki
2014
Tampere University Hospital
2014
Tampere University
2014
Lundbeck (United States)
2014
Deerfield (United States)
2014
In-Q-Tel
2012
Neurology, Inc
2004
Abstract We report the first long-term follow-up of a randomized trial (NCT04978259) addressing effects remdesivir on recovery (primary outcome) and other patient-important outcomes one year after hospitalization resulting from COVID-19. Of 208 patients recruited 11 Finnish hospitals, 198 survived, whom 181 (92%) completed follow-up. At year, self-reported occurred in 85% 86% standard care (SoC) (RR 0.94, 95% CI 0.47-1.90). infer no convincing difference between SoC quality life or symptom (...
Objectives: Disorders of cardiovascular and other autonomic nervous system functions are often found in patients with temporal lobe epilepsy (TLE). Cardiovascular dysregulation TLE has previously been quantified assessing traditional time frequency domain measures heart rate (HR) variability from short term ECG recordings. However, new complexity fractal HR based on non-linear dynamics fractals ("chaos theory") may disclose certain patterns that cannot be detected using only conventional...
To measure interictal cardiovascular autonomic functions in patients with either refractory or well-controlled temporal lobe epilepsy (TLE).For assessment, heart rate variation during normal and deep breathing, Valsalva maneuver, tilting were measured 19 chronic TLE, 38 age- sex-matched healthy control subjects. Blood pressure responses to isometric work also evaluated.Heart-rate (HR) breathing (p = 0.006) 0.043) was lower TLE than Heart-rate response 0.036) Blood-pressure showed no...
Abstract Bullous pemphigoid (BP) is an autoimmune blistering skin disease with increasing incidence. BP associated neurological disorders, but it has not been established, what subtypes of dementia and stroke are BP, the temporal relation between these diseases. Also, association psychiatric disorders controversial. We conducted a retrospective nationwide study, using Finnish Care Register for Health diagnoses 1987 2013. The study population 4524 patients were compared 66138 basocellular...
Sleep promotes cerebrospinal fluid (CSF) to interstitial (ISF) exchange in brain facilitated by pulsations. Especially vasomotion and arterial pulsations modulated noradrenaline drive the intracranial dynamics. Narcolepsy type 1 (NT1) entails lessened hypocretinergic output wake-promoting systems including noradrenergic locus coeruleus. As arousal state signaling affect CSF-ISF clearance, we chose patients with NT1 as a human hypocretin-targeted model of sleep-related pathology bridging gap...
To evaluate the interictal autonomic nervous system function in 84 patients with epilepsy: 37 newly diagnosed, previously untreated epilepsy, and 47 receiving long-term carbamazepine (CBZ), phenytoin (PHT), or valproate (VPA) monotherapy, CBZ plus PHT, VPA for their seizure disorder.We assessed control of cardiovascular regulatory by standardized reflex tests measuring changes heart rate (HR) blood pressure (BP) at rest after certain stimuli.The HR BP responses were similar to those subjects...
The authors evaluated the contribution of various clinical characteristics to mortality risk and underlying causes death among all adult patients with epilepsy seen at Department Neurology, Oulu University Hospital in Finland during 1996 1997. Hazard ratios (HRs) for 1998-2006 relative a population-based reference cohort were estimated using Cox modeling, adjustment age gender. HR total was 2.66 (95% confidence interval [CI] 2.09-3.39). Infectious etiology (HR 5.77, 95% CI 2.52-13.2) seizure...
Epilepsy causes measurable irregularity over a range of brain signal frequencies, as well autonomic nervous system functions that modulate heart and respiratory rate variability. Imaging dynamic neuronal signals utilizing simultaneously acquired ultra-fast 10 Hz magnetic resonance encephalography (MREG), direct current electroencephalography (DC-EEG), near-infrared spectroscopy (NIRS) can provide more comprehensive picture human function. Spectral entropy (SE) is nonlinear method to...
Summary: Purpose: Cardiovascular dysregulation has been detected in patients with temporal lobe epilepsy (TLE) by using cardiovascular reflex tests and analysis of heart rate variability (HRV). The two methods have not previously used the same study to compare them assessment cardioregulatory function. Magnetic resonance imaging (MRI) is considered best method reveal structural changes such as hippocampal sclerosis associated TLE. It known whether these modify function Methods: Standard...
Abstract Introduction Functional magnetic resonance imaging ( fMRI ) combined with simultaneous electroencephalography EEG ‐ has become a major tool in mapping epilepsy sources. In the absence of detectable epileptiform activity, resting state may still detect changes blood oxygen level‐dependent signal, suggesting intrinsic alterations underlying brain physiology. Methods this study, we used coefficient variation CV critically sampled 10 Hz ultra‐fast (magnetoencephalography, MREG signal to...
Respiratory brain pulsations have recently been shown to drive electrophysiological activity in patients with epilepsy. Furthermore, functional neuroimaging indicates that respiratory increased variability and amplitude epilepsy compared healthy individuals. To determine whether the is altered epilepsy, we pulsation synchronicity between controls patients. Whole fast magnetic resonance imaging was performed on 40 medicated focal 20 drug-naïve 102 controls. Cerebrospinal fluid associated were...
Abstract Background Narcolepsy is a chronic neurological disease characterized by daytime sleep attacks, cataplexy, and fragmented sleep. The hypothesized to arise from destruction or dysfunction of hypothalamic hypocretin-producing cells that innervate wake-promoting systems including the ascending arousal network (AAN), which regulates via release neurotransmitters like noradrenalin. Brain pulsations are thought drive intracranial cerebrospinal fluid flow linked brain metabolite transfer...
Abstract Resting-state functional MRI has shown potential for detecting changes in cerebral blood oxygen level-dependent signal patients with epilepsy, even the absence of epileptiform activity. Furthermore, it been suggested that coefficient variation mapping fast may provide a powerful tool identification intrinsic brain pulsations neurological diseases such as dementia, stroke and epilepsy. In this study, we used sequence (magnetic resonance encephalography) to acquire ten whole-brain...
Background Epilepsy is associated with sudden death, but the reasons for this association are not well known.Objective We studied role of antiepileptic drugs (AEDs) as a factor contributing to cardiac death (SCD) in The Finnish Study Genotype and Phenotype Characteristics Sudden Cardiac Death (FinGesture).Methods results FinGesture study compares characteristics victims SCD caused by an autopsy-verified acute coronary event (cases) vs. survivors (ACS) (controls). population comprised 3737...
There is a need to develop effective educational experience in neurology improve the students' skills diagnosing and managing patients with neurological symptoms or disease. The aim of this study was investigate medical attitudes emotions towards before after four week clinical course at two Finnish Universities order find elements learning by decreasing emotional stress studies. In two-stage study, 58 students participated an internet survey open-ended questions completing course. content...
Summary Objective Previous studies have suggested that heterozygous variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase gamma ( POLG 1 ) increase the risk for liver injury patients on valproate VPA therapy. We assessed prevalence of these common seven other pathogenic mutations determined occurrence ‐induced hepatotoxicity VHT or pancreatic toxicity a cohort with epilepsy. Methods Patients epilepsy (N = 367) were retrospectively identified from medical record files screened . who...
Objective. To evaluate spectral heart rate (HR) variation using short-term ECG recordings at rest and during the tilt table test. Methods. The values of components total power (TP), high-frequency (HF), low-frequency (LF) LF: HF ratio were measured head-up in patients with temporal lobe epilepsy (TLE) their control subjects. Results. Compared to subjects, TLE had lower (P < 0.05) LF : TP 0.001), 0.05), tilt. Upon changing from supine standing position attenuated compared Conclusion. These...
Abstract Respiratory brain pulsations pertaining to intra-axial hydrodynamic solute transport are markedly altered in focal epilepsy. We used optical flow analysis of ultra-fast functional magnetic resonance imaging (fMRI) data investigate the velocity characteristics respiratory impulse propagation patients with epilepsy treated antiseizure medication (ASM) (medicated epilepsy; ME, n = 23), drug-naïve at least one seizure (DN, 19) and matched healthy control subjects (HC, 75). detected two...
Abstract Narcolepsy is a chronic neurological disease characterized by dysfunction of the hypocretin system in brain causing disruption wake-promoting system. In addition to sleep attacks and cataplexy, patients with narcolepsy commonly report cognitive symptoms while objective deficits sustained attention executive function have been observed. Prior resting-state functional magnetic resonance imaging (fMRI) studies reported decreased inter/intranetwork connectivity regarding default mode...