A5060992415- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Family and Patient Care in Intensive Care Units
- Hemodynamic Monitoring and Therapy
- Trauma and Emergency Care Studies
- Nosocomial Infections in ICU
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Nausea and vomiting management
- Anesthesia and Sedative Agents
- Poisoning and overdose treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Pneumonia and Respiratory Infections
- EEG and Brain-Computer Interfaces
- Immune Response and Inflammation
- Pancreatitis Pathology and Treatment
- Appendicitis Diagnosis and Management
- Cardiovascular Function and Risk Factors
Oulu University Hospital
2015-2024
University of Oulu
2015-2024
National Heart Institute
2024
Helsinki University Hospital
2015-2017
Turku University Hospital
2015-2017
Tampere University
2013-2016
Tampere University Hospital
2013-2016
Intensive Care Foundation
2004-2014
Intensive Care Society
2013
May Institute
2012
Objective: To study long-term mortality, quality of life (QOL), quality-adjusted years (QALYs), and costs per QALY in an unselected intensive care unit (ICU) patient population with severe sepsis. Design: Prospective observational cohort study. Setting: Twenty-four ICUs Finland. Patients: A total 470 adult patients sepsis who were treated between November 1, 2004 February 28, 2005. The QOL before critical illness was assessed 252 after 156 (58% the surviving April 30, 2006). Ninety-eight...
Background. The role of viral infections in the etiology severe community-acquired pneumonia (SCAP) was prospectively evaluated from 2008 to 2012 at a university-level intensive care unit.
Abstract We report the first long-term follow-up of a randomized trial (NCT04978259) addressing effects remdesivir on recovery (primary outcome) and other patient-important outcomes one year after hospitalization resulting from COVID-19. Of 208 patients recruited 11 Finnish hospitals, 198 survived, whom 181 (92%) completed follow-up. At year, self-reported occurred in 85% 86% standard care (SoC) (RR 0.94, 95% CI 0.47-1.90). infer no convincing difference between SoC quality life or symptom (...
<i>Aims:</i> Effects of a new endotoxin adsorber on the length noradrenaline (NA) treatment, LPS (lipopolysaccharide) levels and SOFA (sequential organ failure assessment) scores in septic shock were evaluated. <i>Methods:</i> Two-hour hemoperfusion with was initiated patients endotoxemia. Controls matched for age, focus severity illness. <i>Results:</i> Adsorption treatment (n = 9) exhibited significant decrease EAA (endotoxin activity assay) (0.55...
Neurocritical illness is a growing healthcare problem with profound socioeconomic effects. We assessed differences in costs and long-term outcome for different forms of neurocritical illnesses treated the intensive care unit (ICU).We used prospective Finnish Intensive Care Consortium database to identify all adult patients traumatic brain injury (TBI), intracerebral hemorrhage (ICH), subarachnoid (SAH) acute ischemic stroke (AIS) at university hospital ICUs Finland during 2003-2013. Outcome...
Abstract Background Neuroinflammation often develops in sepsis along with increasing permeability of the blood-brain barrier (BBB), which leads to septic encephalopathy. The is formed by tight junction structures between cerebral endothelial cells. We investigated expression proteins related brain autopsy specimens critically ill patients deceased and analyzed relationship BBB damage measures systemic inflammation organ dysfunction. Methods case series included all (385) adult due years...
The aim of this study was to elucidate the impact intensive care unit (ICU)-acquired infection on hospital mortality.Patients with a longer than 48 hour stay in mixed 10 bed ICU tertiary-level teaching were prospectively enrolled between May 2002 and June 2003. Risk factors for mortality analyzed logistic regression model.Of 335 patients, 80 developed ICU-acquired infection. Among patients infections, always higher, regardless whether or not had admission (infection group (IAG), 35.6% versus...
Background: Acute acalculous cholecystitis (AAC) is a serious complication of critical illness. We evaluated the underlying diseases, clinical and diagnostic features, severity associated organ failures, outcome operatively treated AAC in mixed ICU patient population. Methods: The data all patients who had confirmed during their stay between 1 January 2000 31 December 2001 were collected from hospital records intensive care unit's management system for predetermined variables. Results:...
The prehospital research field has focused on studying patient survival in cardiac arrest, as well acute coronary syndrome, stroke, and trauma. There is little known about the overall short-term mortality its predictability unselected patients. This study examines whether a National Early Warning Score (NEWS) predicts 1-day 30-day mortalities. Data from all emergency medical service (EMS) situations were coupled to data obtained Causes of Death Registry during six-month period Northern...
The number of missions in the emergency medical services (EMS) has increased considerably recent years. People are requesting ambulance for even minor illnesses and non-medical problems, which is placing financial resource burdens on EMS. aim this study was to determine rate non-transportation Northern Finland reasons these missions.All two hospital districts during 6-month period January 1 through June 30, 2014, were retrospectively evaluated from EMS charts identify patients not...
Injury to endothelium and glycocalyx predisposes vascular leak, which may subsequently lead increased fluid requirements worse outcomes. In this post hoc study of the prospective multicenter observational Finnish Acute Kidney (FINNAKI) cohort conducted in 17 intensive care units, we studied association Syndecan-1 (SDC-1), Angiopoetin-2 (Ang-2), soluble thrombomodulin (sTM), adhesion protein-1 (VAP-1) interleukin-6 (IL-6) with administration balance among septic critical patients their...
Introduction Low levels of vitamin D have been associated with increased mortality in patients that are critically ill. This study explored whether were 90-day severe sepsis or septic shock.Methods Plasma measured on admission to the intensive care unit (ICU) a prospective multicentre observational study.Results 610 included; these, 178 (29%) had shock. Vitamin deficiency (<50 nmol/L) was present 333 (55%) patients. The did not differ among without (28.3% vs. 28.5%, p = 0.789). Diabetes more...
Early diagnosis is essential but challenging in severe sepsis. Quantifying and comparing metabolite concentrations serum has been suggested as a new diagnostic tool. Here we used proton nuclear magnetic resonance spectroscopy (1H NMR) based metabolomics to analyze the possible differences between sera taken from septic patients healthy controls, well of surviving non-surviving sepsis patients. We took samples 44 when first induced organ dysfunction was found. Serum were also collected 14 age...