A5086676477- Traumatic Brain Injury and Neurovascular Disturbances
- Sepsis Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Arrest and Resuscitation
- Cardiac and Coronary Surgery Techniques
- Hemodynamic Monitoring and Therapy
- Cardiac Ischemia and Reperfusion
- Neurosurgical Procedures and Complications
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Intensive Care Unit Cognitive Disorders
- Pancreatitis Pathology and Treatment
- Acute Kidney Injury Research
- Respiratory Support and Mechanisms
- Pancreatic and Hepatic Oncology Research
- Pharmacological Effects and Toxicity Studies
- Intracranial Aneurysms: Treatment and Complications
- S100 Proteins and Annexins
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac electrophysiology and arrhythmias
- Takotsubo Cardiomyopathy and Associated Phenomena
- Epilepsy research and treatment
Oulu University Hospital
2012-2022
University of Oulu
2004-2021
Intensive Care Society
2013
Tampere University Hospital
2013
Tampere University
2013
Intensive Care Foundation
2012
<i>Aims:</i> Effects of a new endotoxin adsorber on the length noradrenaline (NA) treatment, LPS (lipopolysaccharide) levels and SOFA (sequential organ failure assessment) scores in septic shock were evaluated. <i>Methods:</i> Two-hour hemoperfusion with was initiated patients endotoxemia. Controls matched for age, focus severity illness. <i>Results:</i> Adsorption treatment (n = 9) exhibited significant decrease EAA (endotoxin activity assay) (0.55...
The aim was to determine predictors of hospital and 1-year mortality in patients with intensive care unit (ICU)-treated refractory status epilepticus (RSE) a population-based study. This retrospective study the Finnish Intensive Care Consortium (FICC) database adult (16 years age or older) ICU-treated RSE Finland during 3-year period (2010–2012). consists admissions all 20 hospitals treating ICU. All five university 11 out 15 central participated present total referral population 3.92...
Introduction Low levels of vitamin D have been associated with increased mortality in patients that are critically ill. This study explored whether were 90-day severe sepsis or septic shock.Methods Plasma measured on admission to the intensive care unit (ICU) a prospective multicentre observational study.Results 610 included; these, 178 (29%) had shock. Vitamin deficiency (<50 nmol/L) was present 333 (55%) patients. The did not differ among without (28.3% vs. 28.5%, p = 0.789). Diabetes more...
Electrocardiographic (ECG) abnormalities are frequent in patients with intracranial insult. In this study, we evaluated the factors predisposing to repolarization abnormalities, i.e., prolonged corrected QT (QTc) interval, ischemic-like ECG changes and morphologic end-repolarization examined prognostic value of these subarachnoid intracerebral hemorrhages requiring intensive care.This was a prospective, observational clinical study university-level care unit. Clinical characteristics, level...
Background A high prevalence of delirium is observed in sepsis, yet specific markers for this brain dysfunction sedated patients are still lacking. Cytoplasmic low molecular weight calcium‐binding protein, S‐100β, a commonly used nonspecific marker injury. Here, we evaluated whether associated with increases S‐100β levels. Methods This observational study included 22 septic shock. Delirium was assessed by CAM ‐ ICU and blood samples were obtained to measure inflammatory ( CRP , PCT IL ‐6,...
BACKGROUND: Neurogenic pulmonary edema (NPE) is a well-recognized phenomenon after intracranial insult. In this study, we evaluated the predictors for NPE and its association with outcome in patients intensive care unit–treated nontraumatic hemorrhage. METHODS: This was prospective, observational clinical study university-level unit. Clinical characteristics, level of consciousness, Acute Physiology Chronic Health Evaluation (APACHE) II score were recorded on admission findings primary head...
No predictive models for long-term mortality in critically ill patients with acute kidney injury (AKI) exist. We aimed to develop and validate two one-year AKI based on data (1) intensive care unit (ICU) admission (2) the third day (D3) ICU.This substudy of FINNAKI study comprised 774 early (diagnosed within 24 hours ICU admission). selected predictors a priori previous studies, clinical judgment, differences between survivors non-survivors AKI. validated internally bootstrapping.Of...
Although tissue perfusion is often decreased in patients with sepsis, the relationship between macrohemodynamics and microcirculatory blood flow poorly understood. We hypothesized that alterations retinal visualized by angiography may be related to macrohemodynamics, inflammatory mediators, changes. Retinal fluorescein was performed twice during first 5 days intensive care unit observe abnormalities sepsis. changes were documented hyperfluorescence angiography; measured as arterial filling...
Abstract Introduction Transfusion of red blood cells (RBCs) and, in particular, older RBCs has been associated with increased short-term mortality critically ill patients. We evaluated the association between age transfused and acute kidney injury (AKI), hospital, 90-day Methods conducted a prospective, observational, predefined sub-study within FINNish Acute Kidney Injury (FINNAKI) study. This study included all elective ICU admissions expected stay more than 24 hours emergency from...
To examine whether intestinal bacterial translocation occurs early in acute mild and severe pancreatitis the expression of tight junction proteins (claudins-2, -3, -4, -5, -7), apoptosis or proliferation would explain possible translocation.Fifteen pigs were randomized to controls (n=5) develop edematous (n=5, saline infusion pancreatic duct) necrotic taurocholic acid infusion). Translocation was studied by measuring cultures from portal vein blood mesenteric lymph nodes. Immunohistochemical...
Indications for renal replacement therapy (RRT) have not been generally standardized and vary among intensive care units (ICUs). We aimed to assess the proportion, indications, modality of RRT, as well association between proportion RRT use 90-day mortality in patients with septic shock Finnish adult ICUs. identified from prospective observational multicenter FINNAKI study conducted 1 September 2011 February 2012. divided ICUs into high-RRT low-RRT according median RRT-treated shock....
Background The aim of this study was to assess the incidence and contributing factors hypophosphatemia association with poor long‐term outcome after nontraumatic intracranial hemorrhage. Methods This a prospective, observational patients hemorrhage (i.e., aneurysmal or perimesencephalic subarachnoid hemorrhage, spontaneous intracerebral intraventricular hemorrhage) treated in intensive care unit ( ICU ) at our university hospital. Plasma phosphate concentrations were measured serially 2‐day...
Background. Ischemia-reperfusion injury secondary to leukocyte activation has been widely recognized as one of the most relevant mechanism leading postoperative organ dysfunction occurring after a period ischemia. The aim present study was evaluate in prospective, randomized study, value depleting filter patients undergoing elective coronary artery bypass surgery. Methods. Twenty scheduled for on-pump surgery were undergo cardiopulmonary either with incorporated extracorporeal circulation...
Slow waves (less than 1 Hz) are the most important electroencephalogram signatures of nonrapid eye movement sleep. While considered to have a substantial importance in, for example, providing conditions single-cell rest and preventing long-term neural damage, disturbance in this neurophysiologic phenomenon is potential indicator brain dysfunction.Since, healthy individuals, slow can be induced with anesthetics, authors tested possible association between hypoxic injury slow-wave activity...
Abstract Objective. When developing approaches for automatic preprocessing of electroencephalogram (EEG) signals in non-isolated demanding environment such as intensive care unit (ICU) or even outdoor environment, one the major concerns is varying nature characteristics different artifacts time, frequency and spatial domains, which turn causes a simple approach to be not enough reliable artifact removal. Considering this, current study aims use correlation-driven mapping improve detection...
Centralized trauma care has been shown to be associated with improved patient outcome. We compared the outcomes of patients in relation size intensive unit (ICU) using a large Finnish database.A national prospectively collected ICU data registry was used for analysis. All adult admissions excluding isolated head and burns registered from July 1999 December 2006 were analyzed. Data 22 ICUs available. The non-university-affiliated units categorized according number beds referral population as...
Abstract Mortality remains high after emergency open surgery for a ruptured abdominal aortic aneurysm (RAAA). The aim of the present study was to assess, if intravenous (IV) Interferon (IFN) beta-1a improve survival by up-regulating Cluster differentiation (CD73). This is multi-center phase II double-blind, 2:1 randomized, parallel group comparison efficacy and safety IV IFN vs. placebo prevention death an infra-renal RAAA. All patients presented confirmed RAAA, survived primary were treated...
Cytokines initiate and modify systemic inflammatory response in early acute pancreatitis. The aim of this study was to analyze which cytokines are released from the pancreas portal venous blood phase experimental necrotizing oedematous pancreatitis those correlated with more severe form disease.Fifteen pigs were randomized develop mild (n = 5, saline infusion pancreatic duct), taurocholic acid infusion) along a control group 5). Arterial samples drawn cytokine levels measured vein at 0, 120,...
In a recent study, we proposed novel method to evaluate hypoxic ischemic encephalopathy (HIE) by assessing propofol-induced changes in the 19-channel electroencephalogram (EEG). The study suggested that patients with HIE are unable generate EEG slow waves during propofol anesthesia 48 h after cardiac arrest (CA). Since low number of electrodes would make clinically more practical, now investigated whether our results received full cap could be reproduced using only forehead electrodes....
EEG slow wave activity (SWA) has shown prognostic potential in post-resuscitation care. In this prospective study, we investigated the accuracy of continuously measured early SWA for prediction outcome comatose cardiac arrest (CA) survivors.We recorded with a disposable self-adhesive frontal electrode and wireless device starting from ICU admission until 48 h return spontaneous circulation (ROSC) CA survivors sedated propofol. We determined by offline calculation C-Trend® Index describing as...
Aim: The ultrastructural changes in the intestine were studied during experimental acute edematous and necrotizing porcine pancreatitis. immunohistochemical expression of E-cadherin β-catenin jejunum colon was assessed to characterize adherens junctions.Methods: Twenty-four pigs randomized controls (n = 8) or develop mild 8, saline infusion pancreatic duct) severe pancreatitis taurocholic acid infusion). ultrastructure mesenteric artery vein epithelium analyzed at baseline after 540 min with...