A5036950089- Intensive Care Unit Cognitive Disorders
- Dementia and Cognitive Impairment Research
- Anesthesia and Sedative Agents
- Sepsis Diagnosis and Treatment
- Alcoholism and Thiamine Deficiency
- Geriatric Care and Nursing Homes
- Cardiac Arrest and Resuscitation
- Pancreatitis Pathology and Treatment
- Anesthesia and Neurotoxicity Research
- Palliative Care and End-of-Life Issues
- Pharmaceutical Practices and Patient Outcomes
- Gallbladder and Bile Duct Disorders
- Family and Patient Care in Intensive Care Units
- EEG and Brain-Computer Interfaces
- Frailty in Older Adults
- Respiratory Support and Mechanisms
- Research in Social Sciences
- Appendicitis Diagnosis and Management
- Schizophrenia research and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Decision-Making and Restraints
- Nosocomial Infections in ICU
- Pancreatic and Hepatic Oncology Research
- Poisoning and overdose treatments
- Muscle and Compartmental Disorders
University of Oulu
2007-2024
Helsinki University Hospital
2008-2022
University of Helsinki
2002-2022
Oulu University Hospital
2007-2020
Intensive Care Foundation
2001-2010
Fukushima Medical University
2007
Nepean Hospital
2007
Sapienza University of Rome
2007
University of Colorado Denver
2007
Herttoniemi Hospital
2006
Background. Delirium is a common syndrome with poor prognosis affecting elderly inpatients. Treatment mainly based on sense wide variations in practice. We investigated whether intensified, multicomponent geriatric treatment could improve the of delirious patients.
Our aim was to investigate the long-term prognosis of delirium in frailest elderly, and clarify whether is just a marker underlying severe disease. We used logistic regression analysis determine independent prognostic significance delirium. A representative sample 425 patients (> or = 70 years) acute geriatric wards nursing homes were assessed at baseline followed up for 2 years. DSM-IV classification. The prevalence 24.9% (106/425). poor: mortality 1 year 34.9 vs. 21.6% nondelirious...
<i>Aims:</i> Effects of a new endotoxin adsorber on the length noradrenaline (NA) treatment, LPS (lipopolysaccharide) levels and SOFA (sequential organ failure assessment) scores in septic shock were evaluated. <i>Methods:</i> Two-hour hemoperfusion with was initiated patients endotoxemia. Controls matched for age, focus severity illness. <i>Results:</i> Adsorption treatment (n = 9) exhibited significant decrease EAA (endotoxin activity assay) (0.55...
Objectives: To describe the prevalence of various psychiatric and behavioral symptoms among patients with dementia in nursing homes acute geriatric wards to investigate administration psychotropic medications these patients. Methods: 425 consecutive (>70 years) six two city hospitals seven Helsinki, Finland, were assessed an extensive interview, cognitive tests, attention tests. Of these, 255 judged have according following information: previous diagnoses their adequacy, results CT scans,...
The aim of this study was to elucidate the impact intensive care unit (ICU)-acquired infection on hospital mortality.Patients with a longer than 48 hour stay in mixed 10 bed ICU tertiary-level teaching were prospectively enrolled between May 2002 and June 2003. Risk factors for mortality analyzed logistic regression model.Of 335 patients, 80 developed ICU-acquired infection. Among patients infections, always higher, regardless whether or not had admission (infection group (IAG), 35.6% versus...
Background: Acute acalculous cholecystitis (AAC) is a serious complication of critical illness. We evaluated the underlying diseases, clinical and diagnostic features, severity associated organ failures, outcome operatively treated AAC in mixed ICU patient population. Methods: The data all patients who had confirmed during their stay between 1 January 2000 31 December 2001 were collected from hospital records intensive care unit's management system for predetermined variables. Results:...
Background Delirium is a frequent post‐stroke complication that compromises effective rehabilitation and has been associated with poor outcome. We aimed to investigate whether delirium increased risk of dementia long‐term mortality once confounding taken into account. Methods The study comprised 263 consecutive acute ischemic stroke patients aged 55–85 years admitted the emergency department university hospital. cohort included three‐month survivors followed up for 10 years. diagnosis during...
To investigate the use of drugs with anticholinergic properties (DAPs) and their associations delirium mortality among elderly patients comorbidities.425 (≥70 years age) in geriatric wards nursing homes were assessed. The DAPs was retrieved from medical records. Delirium diagnosed according to DSM-IV criteria.Of 341 (80.2%) treated multiple (≥2), 92 (27.0%) suffered delirium, whereas 14 84 (16.7%) without DAP treatment had (p = 0.050). In a logistic regression analysis age, gender, Charlson...
A cross-sectional study was performed to evaluate the concordance of present criteria delirium among elderly (>70 years) geriatric hospital patients (n = 230) and nursing home residents 195). Different subjects were diagnosed as having when operationalized according American Psychiatric Association’s Diagnostic Statistical Manual Mental Disorders (DSM-III, DSM-III-R, DSM-IV) World Health Organization’s International Classification Diseases (ICD-10) used. Whereas 132 (31.1%) met for by at...
Abstract Background The Confusion Assessment Method (CAM) is an easy, four‐step algorithmic diagnostic test developed to detect delirium. Objective To determine how sensitive and specific the CAM in diagnosing delirium when compared with fully operationalized criteria of according Diagnostic Statistical Manual Mental Disorders (DSM) editions III, III revised, IV, International Classification Diseases (ICD) 10th edition. Methods A cross‐sectional study blinded assessments was performed on...
The detrimental effects of delirium on functioning and mortality are well known, but health-related quality life (HRQoL) costs care have rarely been investigated among patients with delirium. We studied the multicomponent geriatric treatment HRQoL in delirious inpatients.A randomized, controlled trial 174 inpatients was performed an acute hospital. intervention individually tailored treatment. measured by 15D instrument subjective health a four-level ordinal scale. Health including were...
A 2-year follow-up study was performed to compare the prognosis of delirium defined according 4 different diagnostic classifications (DSM-III, DSM-III-R, DSM-IV and ICD-10 clinical criteria) among 425 elderly geriatric hospital patients nursing home residents. The proportion varied from 24.9% (DSM-IV) 10.1% (ICD-10). prognoses were similar particularly all DSM classifications: 31.3–36.3% delirious died within 1 year 57.8–62.5% 2 years. number subjects diagnosed as small, their did not differ...
Abstract Background Different diagnostic criteria differ in their capacity to identify subjects as delirious. It is not known how DSM‐IV classification, compared with the DSM‐III, DSM‐III‐R, and ICD‐10, identifies delirium among individuals without dementia whether symptom profiles between these two subgroups. Methods A cross‐sectional study was performed on patients (age ≥ 70 years) seven acute geriatric wards ( n = 230) nursing‐homes 195) Helsinki, Finland. Delirium diagnosed according...
Abstract Introduction Sepsis-related multiple organ dysfunction is a common cause of death in the intensive care unit. The effect sepsis on markers tissue repair only partly understood. aim this study was to measure collagen synthesis and degradation during investigate association with disease severity outcome. Methods Forty-four patients severe participated 15 volunteers acted as controls. Blood samples were collected for 10 days after first sepsis-induced three six months. Procollagen type...