A5084753648- Dementia and Cognitive Impairment Research
- Schizophrenia research and treatment
- Pharmaceutical Practices and Patient Outcomes
- Frailty in Older Adults
- Balance, Gait, and Falls Prevention
- Research in Social Sciences
- Health Systems, Economic Evaluations, Quality of Life
- Intergenerational Family Dynamics and Caregiving
- Sleep and related disorders
- Chronic Disease Management Strategies
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Nutrition and Health in Aging
- Geriatric Care and Nursing Homes
- Hip and Femur Fractures
- Immune Cell Function and Interaction
- Ear Surgery and Otitis Media
- Bone health and osteoporosis research
- Healthcare Decision-Making and Restraints
- Palliative Care and End-of-Life Issues
- Child Nutrition and Feeding Issues
- Health disparities and outcomes
- Plant Toxicity and Pharmacological Properties
- Interpreting and Communication in Healthcare
- Medication Adherence and Compliance
Hospital District of Helsinki and Uusimaa
2021-2025
University of Helsinki
2010-2022
Helsinki University Hospital
2007-2022
Primary Health Care
2016
Social Insurance Institution
2007-2011
Åland University of Applied Sciences
2001
To examine whether a regular, long-term exercise program performed by individuals with Alzheimer's disease (AD) at home or as group-based an adult daycare center has beneficial effects on cognition; to secondary outcomes of trial that been published earlier.Randomized, controlled trial.Community.Community-dwelling dyads (N = 210) AD and their spousal caregivers randomized into three groups.Two types intervention comprising customized home-based (HE) (GE), each twice week for 1 year, were...
BackgroundPoor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor respiratory has remained unclear. We examined if contributes as a factor to infections.MethodsWe used data on insomnia, influenza upper (URIs) from primary care hospital records in UK Biobank (N ≈ 231,000) FinnGen 392,000). computed logistic regression assess association infections, disease free survival hazard ratios, performed Mendelian randomization...
To investigate the use of drugs with anticholinergic properties (DAPs) and their associations delirium mortality among elderly patients comorbidities.425 (≥70 years age) in geriatric wards nursing homes were assessed. The DAPs was retrieved from medical records. Delirium diagnosed according to DSM-IV criteria.Of 341 (80.2%) treated multiple (≥2), 92 (27.0%) suffered delirium, whereas 14 84 (16.7%) without DAP treatment had (p = 0.050). In a logistic regression analysis age, gender, Charlson...
BACKGROUND: Adverse pregnancy outcomes (APO) contribute to higher risk of maternal cerebrovascular disease, but longitudinal data that include APO and stroke timing are lacking. We hypothesized associated with younger age at first stroke, a stronger relationship in those >1 APO. METHODS: analyzed Finnish nationwide health registry from the FinnGen Study. included women who gave birth after 1969 when hospital discharge was established. defined as affected by gestational hypertension,...
The caregiving situation among caregivers and their spouses with Alzheimer's disease, the support services received, unmet needs, caregivers' satisfaction are examined. study included a survey of random sample 1943 persons disease in Finland. Mean age was 78.2 years, 35% had poor subjective health. Disabilities behavioral symptoms were common disease. most often offered financial (36%), technical devices (33%), physiotherapy (32%), respite care nursing homes (31%). Most needed for spouse...
Objectives: To examine the experiences of spousal care givers Alzheimer patients to disclosure dementia diagnosis and subsequent care. Methods: A random sample 1943 people receiving medication for disease (AD) was sent a cross-sectional postal survey about their opinions on follow-up smaller qualitative study (n = 63) included open-ended questions concerning same topics. Results: The response rate 77%. Of respondents, 1214 1434 acknowledged themselves as spouse’s giver. mean age 78.2 years,...
<b><i>Background:</i></b> Exercise improves functional performance in subjects with dementia. However, whether the benefits of exercise are evident all stages dementia remains uncertain. This study examines how people different Alzheimer's disease (AD) benefit from intervention their physical functioning and risk falling. <b><i>Methods:</i></b> The present is a subanalysis randomized controlled trial examining effects (twice week for 12 months)...
Besides cognitive decline, Alzheimer's disease (AD) leads to physical disability, need for help and permanent institutional care. The trials investigating effects of exercise rehabilitation on functioning home-dwelling older dementia patients are still scarce. aim this study is investigate the effectiveness intensive lasting one year mobility with AD.During years 2008-2010, AD (n = 210) living their spousal caregiver in community recruited using central registers Finland, they offered year....
Narcolepsy is a severe sleep disorder with characteristics of fatigue, fragmented sleep, cataplexy and hypnagogic hallucinations. Earlier clinical studies have reported the onset schizophrenia after narcolepsy but causality behind unknown. Our goal was to understand between schizophrenia. To estimate comorbidity schizophrenia, we employed data from FinRegistry that contains for total population Finland in 7.2 million individuals (N = 1664 55,372 schizophrenia). We then used Mendelian...
This study aims to assess potentially severe class D drug-drug interactions (DDDIs) in residents 65 years or older assisted living facilities with the use of a Swedish and Finnish interaction database (SFINX).A cross-sectional Helsinki, Finland.A total 1327 were assessed this study. Drugs classified according Anatomical Therapeutic Chemical (ATC) classification system DDDIs coded SFINX.Prevalence DDDIs, associated factors 3-year mortality among residents.Of participants (mean age was 82.7...
To explore how neuropsychiatric symptoms (NPS) are associated with number of falls and exercise modifies the risk falling in community-dwelling people Alzheimer's disease (AD) NPS.Secondary analysis a randomized controlled trial.Community.Community-dwelling individuals AD (N=210) who completed Neuropsychiatric Inventory (NPI) (N = 179).Participants were into 3 groups: group-based (4-hour sessions approximately 1 hour training) tailored home-based (1 twice week for year control group...
<b><i>Background:</i></b> People with dementia are at high risk for falls. However, little is known of the features causing falls in Alzheimer disease (AD). Our aim was to investigate how participants AD fall. <b><i>Methods:</i></b> In FINALEX (Finnish Disease Exercise Trial) study, participants’ (<i>n</i> = 194) were followed up 1 year by diaries kept their spouses. <b><i>Results:</i></b> The most common...
Introduction . Caregiving families of patients with dementia are often reluctant to use support services. The aim this study was describe their subjective critiques these Material and Methods A cross-sectional questionnaire sent a random sample (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>N</mml:mi><mml:mo>=</mml:mo><mml:mn>1943</mml:mn></mml:math>) Alzheimer’s patients’ spouses in Finland an open-ended question: “What kind problems have you faced the services?” Their...
We conducted a cross-sectional survey of random sample 1943 spouses home-dwellers with Alzheimer's disease (AD) to examine the prevalence court-appointed guardians or financial powers attorney for persons AD, related factors and need information about these issues among caregiving families. The questionnaire consisted questions on variables demographic characteristics, disability, symptoms care needs person dementia, strain caregiving, use legal attorney, as well discussions -- them doctor....