A5080965346- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac Ischemia and Reperfusion
- Cardiac and Coronary Surgery Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Tissue Engineering and Regenerative Medicine
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Mesenchymal stem cell research
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Vascular Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Infectious Aortic and Vascular Conditions
- Anesthesia and Neurotoxicity Research
- Thermal Regulation in Medicine
- Aortic aneurysm repair treatments
- Cardiovascular Effects of Exercise
- Eicosanoids and Hypertension Pharmacology
- Neonatal and fetal brain pathology
- Blood transfusion and management
- Intensive Care Unit Cognitive Disorders
Helsinki University Hospital
2019-2024
University of Helsinki
2022-2024
Society of Thoracic Surgeons
2020
Oulu University Hospital
2004-2017
Vaasa Central Hospital
2017
University of Oulu
2003-2011
Nieuwegein Fonds
2007
Centre Hospitalier de Troyes
2007
Park Terrace Care Center
2006
The aim of this study was to compare the risk prosthetic valve endocarditis (PVE) in patients with transcatheter aortic replacement (TAVR) or surgical (SAVR).The FinnValve registry included data from 6,463 consecutive who underwent TAVR (n=2,130) SAVR (n=4,333) a bioprosthesis 2008 2017. PVE defined according modified Duke criteria. In study, incidence 3.4/1,000 person-years after TAVR, and 2.9/1,000 SAVR. competing analysis there no significant difference between over an eight-year...
The aim of this study was to evaluate the incidence and prognostic impact paravalvular regurgitation (PVR) on outcome after transcatheter (TAVR) surgical aortic valve replacement (SAVR) for stenosis.The nationwide FinnValve registry included data 6463 consecutive patients who underwent TAVR (n = 2130) or SAVR 4333) with a bioprosthesis treatment stenosis during 2008-2017. PVR at discharge 4-year mortality herein investigated.The rate mild 21.7% 5.2% SAVR. moderate-to-severe 3.7% 0.7% After...
<h3>Importance</h3> Transcatheter aortic valve replacement (TAVR) has been shown to be a valid alternative surgical (SAVR) in patients at high operative risk with severe stenosis (AS). However, the evidence of benefits and harms TAVR low is still scarce. <h3>Objective</h3> To compare short-term midterm outcomes after SAVR low-risk AS. <h3>Design, Setting, Participants</h3> This retrospective comparative effectiveness cohort study used data from Nationwide Finnish Registry Surgical Aortic...
Abstract Objectives To compare the outcomes after surgical (SAVR) and transcatheter aortic valve replacement (TAVR) for severe stenosis of bicuspid (BAV). Methods We evaluated early mid-term outcome patients with stenotic BAV who underwent SAVR or TAVR from nationwide FinnValve registry. Results The registry included 6463 AS 1023 (15.8%) them had BAV. was performed in 920 103 In overall series, device success comparable to (94.2% vs. 97.1%, p = 0.115). associated increased rate...
Cell homing optimisation after transplantation is critical in myocardial infarction (MI) cell therapy.Eight pigs were randomized to receiving autologous purified (111)indium-labeled bone marrow mononuclear cells (BMMCs) (10(8) cells/2 ml) by intramyocardial (IM) (n=4) or intracoronary (IC) 90 minutes occlusion of the CX-coronary artery. Dual isotope SPECT imaging was performed 2 and 24 hours postoperatively. Two animals additionally analyzed on sixth postoperative day. Tissue samples from...
Aim: We investigated the outcomes of transcatheter (TAVR) and surgical aortic valve replacement (SAVR) in Finland during last decade.Methods: The nationwide FinnValve registry included data from 6463 patients who underwent TAVR or SAVR with a bioprosthesis for stenosis 2008 to 2017.Results: annual number treated increased three-fold study period. Thirty-day mortality declined 4.8% 1.2% (p = .011) 4.1% 1.8% .048). Two-year survival improved 71.4% 83.9% < .001) 87.2% 91.6% .006). During...
Background The present study aimed to determine which method of anaesthesia (spinal or general anaesthesia) is better in reducing post‐operative analgesic requirements patients undergoing major limb amputation for lower‐limb ischaemia. Another aim was find out if anaesthesiologists use neuraxial high‐risk despite abnormal coagulation profile anticoagulation. Methods a retrospective cohort study. All undergone above‐the‐knee below‐the‐knee due peripheral artery disease between 1996 and 2010...
Epitranscriptomic modifications in RNA can dramatically alter the way our genetic code is deciphered. Cells utilize these not only to maintain physiological processes, but also respond extracellular cues and various stressors. Most often, adenosine residues are targeted, result including methylation deamination. Such modified as N-6-methyl-adenosine (m6A) inosine, respectively, have been associated with cardiovascular diseases, contribute disease pathologies. The Ischemic Heart Disease...
Peripheral femoro-femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) is viable for fast hemodynamic assistance during cardiogenic shock. Ultrasound-guided closure with a large-bore device (MANTA®) feasible option potentially replacing surgical arteriotomy in peripheral VA-ECMO decannulation.This retrospective study included patients weaning from percutaneously inserted at the Helsinki University Hospital, Finland 2012-2020. The primary endpoints were access-site...
Membranous septum (MS) length, in conjunction with implantation depth (ID), is known as a determinant of conduction disturbance (CD) after transcatheter aortic valve (TAVI). However, its impact might be dissimilar among types because each has different platform. This study sought to investigate the impacts ID and MS length on new-onset CD between ACURATE neo SAPIEN 3. included patients without previous permanent pacemaker who underwent TAVI 3 divided them into 2 groups based according (deep...
Abstract Background Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, this may result in inferior survival also after valve replacement. The outcomes of transcatheter surgical replacement were investigated comparative analysis. Methods retrospective nationwide FinnValve registry included data on patients who underwent or bioprosthesis for stenosis. Propensity score matching was performed to adjust the baseline covariates reduced (≤ 50%)...