A5040321007- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Kidney Injury Research
- Nausea and vomiting management
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Liver Disease and Transplantation
- Cardiac Arrest and Resuscitation
- Dialysis and Renal Disease Management
- Pancreatitis Pathology and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal function and acid-base balance
- Research in Social Sciences
- Organ Transplantation Techniques and Outcomes
- Patient-Provider Communication in Healthcare
- Chronic Kidney Disease and Diabetes
- Medical Imaging and Pathology Studies
- Inflammasome and immune disorders
- Parathyroid Disorders and Treatments
- Palliative Care and End-of-Life Issues
- Ethics in medical practice
- Pediatric Pain Management Techniques
- Respiratory Support and Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
University of Helsinki
1988-2020
Helsinki University Hospital
2007-2020
Pain and Rehabilitation Medicine
2020
Turku University Hospital
2014-2017
University of Turku
2017
Marymount University
2013
Research Council of Finland
2013
Christie's
2007
Intensive Care Society
2006
Instrumentarium Science Foundation
2006
Pregabalin has anticonvulsant, antihyperalgesic, and anxiolytic properties. In this study we evaluated the control of pain after perioperative administration pregabalin 300 or 600 mg, compared with diazepam 10mg. Altogether 91 women scheduled for laparoscopic hysterectomy were randomized to receive 10mg (D10), 150 mg (P300) (P600) premedication, dose was repeated 12h, except D10 group, in which patients received placebo. Up until 1st postoperative morning, analgesia provided by oxycodone...
This article describes the methods and results of early part (experimental pain tests postoperative analgesia) a study that assesses genetic other factors related to acute persistent after treatment breast cancer in prospective cohort 1,000 women.One thousand consenting patients were recruited study. Before surgery (breast resection or mastectomy with axillary surgery), filled questionnaires about health, life style, depression (Beck Depression Inventory), anxiety (State-Trait Anxiety...
The serum concentration of cystatin C has recently been proposed as a better indicator glomerular filtration rate (GFR) than plasma creatinine. Little is known about in critical illness. We assessed marker renal function acute failure (ARF) and its power predicting survival ARF patients.202 consecutive adult patients admitted into the intensive care unit (ICU) during period 9 months.Serum C, creatinine urea were measured on admission, daily first 3 days, 5-7 times week rest ICU stay. with...
Apart from being antiemetic, glucocorticoids have an analgesic property. The optimal dose of dexamethasone in the management pain after surgery has not been established. In this placebo-controlled, dose-finding study, we evaluated effect three doses laparoscopic hysterectomy.We randomized 129 women scheduled for hysterectomy to receive placebo, 5 mg (D5), 10 (D10), or 15 (D15) IV before induction anesthesia. patients were anesthetized with propofol and remifentanil a standardized manner....
BackgroundInterleukin-18 (IL-18) is a pro-inflammatory protein, which mediates ischaemic tubular injury, and has been suggested to be sensitive specific biomarker for acute kidney injury (AKI). The predictive value of IL-18 in the diagnosis, evolution, outcome AKI critically ill patients still unclear.MethodsWe measured urine from at intensive care unit (ICU) admission 24 h. We evaluated association with developing new AKI, renal replacement therapy (RRT), 90-day mortality. calculated areas...
The pharmacokinetics and ventilatory effects of oxycodone were studied in six volunteer patients with end-stage liver cirrhosis before after orthotopic transplantation. Plasma samples urine collected for 24 hours intravenous administration 0.05 mg/kg hydrochloride. Concentrations its metabolites, noroxycodone oxymorphone, measured plasma urine. median elimination half-life was 13.9 (range, 4.6 to 24.4 hours) transplantation 3.4 2.6 5.1 (p < 0.05). Correspondingly, clearance increased from...
In Brief this prospective, randomized, placebo-controlled, double-blind trial we studied the effects of IV N-acetylcysteine for prevention renal injury in patients undergoing abdominal aortic surgery. Seventy without previously documented dysfunction were randomly allocated to receive either (150 mg/kg mixed 250 mL 5% dextrose infused 20 min, followed by an infusion 150 over 24 h) or placebo. The was started after induction anesthesia. primary outcome measure as measured increases urinary...
Previous human studies have shown low activity of protein C (APC) in severe acute pancreatitis (SAP). This, together with the findings animal models, suggests that activated may protect against pancreatic injury and ameliorate disease. We, therefore, evaluated its effect on multiple organ dysfunction (MOD) measured by SOFA (Sequential Organ Failure Assessment) organ-failure-free days, safety APC SAP. A prospective double blind randomized pilot study was use. The occurred one university...
The Sequential Organ Failure Assessment (SOFA) score is used to quantify the severity of illness daily during intensive care. Our aim was evaluate how accurately SOFA recorded in clinical practice, and whether this can be improved by a refresher course scoring rules.The scores physicians university hospital care unit (ICU) were compared with gold standard determined two expert assessors. Data concerning all consecutive patients 6-week-long observation periods (baseline after course)...
HLA-DR expression and plasma levels of pro- anti-inflammatory cytokines (IL-6, IL-8 IL-10) their predictive value concerning survival critically ill systemic inflammatory response syndrome (SIRS) patients with without acute renal failure (ARF) were evaluated.A total 103 consecutive adult SIRS from 2 university hospital intensive care units participated in the study.Laboratory data for all prospectively collected on day admission days thereafter. Patients non-ARF compared by Mann-Whitney...
How ethical issues are dealt with varies considerably depending on the geographic and religious background of individuals. The views Scandinavian physicians end-of-life care were studied using a survey. aim this study was to clarify actual processes foregoing life-sustaining treatment in Scandinavia.A questionnaire developed sent 78 intensive working Denmark, Finland, Norway Sweden.Forty-four responses obtained (13 from eight 12 11 Sweden); 89% respondents University Hospitals. Withholding...
The internet is a frequently consulted source of health information. Using the Google search engine, we searched for patient information about general anaesthesia on world wide web, using four synonyms term in languages and analysing top 20 results. Of 320 results, 104 (32%) contained relevant information: 36 (45%) with English (UK); 39 (49%) (US); 13 (16%) Swedish; 16 (20%) Finnish terms (p < 0.001). 'Good' websites, defined as those DISCERN rating 4-5 stars, were found all languages: 12 11...
Background: The general principles of medical ethics are universally accepted. In practice, however, there is variation on how these interpreted by people with different cultural backgrounds. aim this study was to document the views Scandinavian intensive care physicians unit (ICU) admission, triage, withholding and withdrawal care, communication between patient, family ICU team. Methods: A questionnaire developed sent 84 working in Denmark, Finland, Sweden Norway. Results: response rate...
In the intensive care unit (ICU), analgesia and sedation are used to improve comfort safety of patients undergoing therapies. However, continuous administration sedatives prolongs time on mechanical ventilation ICU stay. These adverse effects can be reduced by clear definition goals combined with a protocol.The adherence local guideline university affiliated was monitored prospectively before after intervention: reinforcement guideline. The primary endpoints study were occurrence daily...
Cardiac arrest is not a common complication of sepsis, although sepsis has been recognized as one condition behind cardiac arrest. Our aim was to evaluate the prevalence among patients with inhospital (IHCA), and determine if associated inferior outcome after IHCA.All consecutive emergency team dispatches in Turku University Hospital 2011 2014 (n = 607) were retrospectively reviewed identify undergoing cardiopulmonary resuscitation (CPR) for IHCA 301). The patient records criteria severe...