A5015732555- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Gastrointestinal disorders and treatments
- Appendicitis Diagnosis and Management
- Mitochondrial Function and Pathology
- Abdominal Surgery and Complications
- Pancreatic function and diabetes
- Phagocytosis and Immune Regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Celiac Disease Research and Management
- Sepsis Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Diabetes Management and Research
- Genetics, Aging, and Longevity in Model Organisms
- Gallbladder and Bile Duct Disorders
- Diet, Metabolism, and Disease
- Blood properties and coagulation
- Muscle and Compartmental Disorders
- Kawasaki Disease and Coronary Complications
- Renal function and acid-base balance
- Dermatological and COVID-19 studies
- Immune cells in cancer
- Blood Coagulation and Thrombosis Mechanisms
Tampere University
2010-2025
Finnish Environment Institute
2023
Turku Centre for Computer Science
2020-2021
Åbo Akademi University
2017-2021
University of Turku
1998-2021
Helsinki University Hospital
2007-2019
University of Helsinki
2007-2019
Turku Centre for Biotechnology
2017-2019
Tampere University Hospital
1998-2016
Heidelberg University
2004-2012
Pancreatic infections and sepsis are major complications in severe acute pancreatitis (AP) with significant impact on management outcome. We investigated the value of Procalcitonin (PCT) for identifying patients at risk to develop pancreatic AP.
Objective To compare three different multiple organ dysfunction scores in predicting hospital mortality rates and to discover which one best assesses dysfunction/failure patients with severe acute pancreatitis a general intensive care unit. Design Retrospective, observational study. Setting Surgical department ten-bed unit tertiary hospital. Patients Among the 178 consecutive admitted surgical from 1994 1998, 113 treated underwent Interventions None. Measurement Main Results Clinical...
Mutations in mitochondrial oxidative phosphorylation complex I are associated with multiple pathologies, and has been proposed as a crucial regulator of animal longevity. In yeast, the single-subunit NADH dehydrogenase Ndi1 serves non-proton-translocating alternative enzyme that replaces I, bringing about reoxidation intramitochondrial NADH. We have created transgenic strains Drosophila express yeast NDI1 ubiquitously. Mitochondrial extracts from NDI1-expressing flies displayed...
Severe acute pancreatitis (AP) is associated with high morbidity and mortality. Early prediction of severe AP needed to improve patient outcomes. The aim the present study was find novel cytokines or combinations that can be used for early identification patients at risk disease.We performed a prospective 163 nonconsecutive AP, whom 25 had according revised Atlanta criteria. Admission serum levels 48 growth factors were determined using Bio-Plex Pro Human Cytokine Assay 21-plex 27-plex...
Acute pancreatitis can be difficult to diagnose. We developed a rapid dipstick screening test for pancreatitis, based on the immunochromatographic measurement of urinary trypsinogen-2.We prospectively compared trypsinogen-2 with quantitative assay, amylase, and serum amylase assays in 500 consecutive patients acute abdominal pain at two emergency departments. was diagnosed according standardized criteria.The positive 50 53 (sensitivity, 94 percent), including all 7 severe pancreatitis. Two...
Acute pancreatitis (AP) is a common abdominal disorder with severity varying from mild to fatal disease. Predicting patient's outcome remains problematic. The aim of this study was analyze large consecutive series patients severe AP and identify prognostic factors for hospital mortality. Between 1989 1997, 270 were included in the study. All fulfilled criteria Atlanta classification AP. Retrospectively prospectively collected data age, gender, etiology, number previous episodes pancreatitis,...
Abstract Background Several biological markers and clinical scoring systems have been used to predict the course of acute pancreatitis. Because organ failure is most severe complication disease, prognostic their combinations that would on hospital admission were sought. Methods Some 351 consecutive patients with pancreatitis studied. Blood samples taken within 12 h admission. This case–control study included all 33 99 matched controls without failure. Measurements 19 Acute Physiology And...
Early identification of patients who subsequently develop severe acute pancreatitis would enable the selection may benefit from early intensive management. Because is characterized by development systemic inflammation authors studied whether procalcitonin, a marker inflammation, differentiated between with mild and pancreatitis.On admission 24 h thereafter, serum procalcitonin level was measured rapid, semiquantitative PCT-Q test C-reactive protein (CRP) an immunoturbidimetric method in...
Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D preceded by dysregulation lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids prospective series 428 plasma samples from 40 who progressed (PT1D), developed at least single islet autoantibody but did not progress during follow-up (P1Ab) and matched controls (CTR). Sphingomyelins were found be persistently...
Abstract Aims/hypothesis Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct patterns occur in peripheral blood mononuclear cells (PBMCs) children who later develop pancreatic beta cell autoimmunity or overt diabetes. Methods In a longitudinal cohort setting, PBMC metabolomic analysis applied (1) progressed (PT1D, n = 34), (2) seroconverted ≥1 islet autoantibody without...
Objective To investigate whether marker(s) of systemic inflammation detect, at an early stage acute pancreatitis, patients who may ultimately develop severe disease. Design Prospective study. Setting University hospital emergency unit. Patients Thirty with mild pancreatitis (SEV0 group) and 27 pancreatitis. Of the latter, 11 did not organ failure (SEV1 group), whereas other 16 developed respiratory 9 them also renal (SEV2 group). Interventions Blood samples were collected admission to (T0),...
Abstract A total of 161 primary contrast-enhanced computed tomography (CT) scans patients with acute necrotizing pancreatitis taken between 1982 and 1994 were analysed retrospectively. The aim was to assess the prognostic significance extent anatomical site pancreatic tissue necrosis in first CT scan. obtained a mean 2·9 days after onset symptoms. head affected 107 patients, body 119 tail 138. Pancreatic necrosis, when divided into four groups according site, correlated overall clinical...
Serum amyloid A (SAA) is an early and sensitive marker of the extent tissue trauma inflammation. The aim this study was to compare prognostic accuracy SAA with that serum C-reactive protein (CRP) in acute pancreatitis.In a prospective multicentre trial, plasma CRP levels were measured patients severe mild pancreatitis, control group abdominal pain. Plasma samples collected on admission at 6-h intervals for 48 h, every 12 h between 72 then daily 5 days. by new enzyme-linked immunosorbent...
A point mutation in the Drosophila gene technical knockout (tko), encoding mitoribosomal protein S12, was previously shown to cause a phenotype of respiratory chain deficiency, developmental delay, and neurological abnormalities similar those presented many human mitochondrial disorders, as well defective courtship behavior.Here, we describe transcriptome-wide analysis expression tko(25t) mutant flies that revealed systematic compensatory changes genes connected with metabolism, including...
Abstract Introduction Severe acute pancreatitis is associated with systemic inflammation, compensatory immune suppression, secondary infections, vital organ dysfunction, and death. Our study purpose was to delineate signaling profiles of circulating lymphocytes in complicated by dysfunction. Methods Sixteen patients pancreatitis, dysfunction organ(s), suppression (proportion HLA-DR Human Leukocyte Antigen - DR positive monocytes < 80%) participated. Healthy volunteers served as reference...
<h3>Abstract</h3> <b>Objective</b>: To estimate the usefulness of serum concentrations complex trypsin 2 and (alpha)1 antitrypsin in diagnosing assessing severity acute pancreatitis comparison with C reactive protein, amylase, trypsinogen (reference markers). <b>Design</b>: Markers were measured consecutive patients admitted abdominal pain that was either due to or other disease unrelated pancreas (controls). <b>Setting</b>: Department surgery a teaching hospital Helsinki. <b>Subjects</b>:...
Although jejunal diverticulosis is a rare entity and usually asymptomatic, it may cause chronic symptoms acute complications. Because of the rarity entity, diagnosis often delayed, resulting in unnecessary morbidity mortality. The purpose this study was to draw attention diverticula their medical records 8 consecutive patients with complications due small‐bowel treated at our department during past 4 years were reviewed. All located jejunum. Seven had complications, 3 an intra‐abdominal...
Hospital mortality in patients with severe acute pancreatitis (SAP) remains high. Some of these develop increased intra-abdominal pressure (IAP) which may contribute to organ dysfunction. The aims this study were evaluate the frequency IAP SAP and assess development dysfunction factors associated high IAP. During 2001–2003 a total 59 treated intensive care unit (ICU) Helsinki University Hospital. was measured by intravesical route 37 SAP. Data from retrospectively reviewed. Maximal IAP,...
Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to diabetes have a circulatory polar metabolite profile distinct from that later islet autoimmunity but not matched control group. We analysed metabolites 415 longitudinal plasma samples prospective cohort three study groups: those progressed diabetes;...