A5035653009- Per- and polyfluoroalkyl substances research
- Immune Cell Function and Interaction
- Neurotransmitter Receptor Influence on Behavior
- T-cell and B-cell Immunology
- Neuroscience and Neuropharmacology Research
- Sphingolipid Metabolism and Signaling
- Pharmacological Effects and Assays
- Diabetes and associated disorders
- Analytical Chemistry and Chromatography
- Pancreatic function and diabetes
- Cannabis and Cannabinoid Research
- Methemoglobinemia and Tumor Lysis Syndrome
- Protein Hydrolysis and Bioactive Peptides
- Toxic Organic Pollutants Impact
- Animal Genetics and Reproduction
- Diet, Metabolism, and Disease
- Diabetes Management and Research
Turku Centre for Computer Science
2019-2021
University of Turku
2019-2021
Åbo Akademi University
2019-2021
Abstract There is evidence of a positive association between per- and polyfluoroalkyl substances (PFASs) cholesterol levels in human plasma, which may be due to common reabsorption PFASs bile acids (BAs) the gut. Here we report development validation method that allows simultaneous, quantitative determination BAs using 150 μL or 20 sample. The involves protein precipitation 96-well plates. instrumental analysis was performed with ultra-performance liquid chromatography–tandem mass...
Abstract Aims/hypothesis Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct patterns occur in peripheral blood mononuclear cells (PBMCs) children who later develop pancreatic beta cell autoimmunity or overt diabetes. Methods In a longitudinal cohort setting, PBMC metabolomic analysis applied (1) progressed (PT1D, n = 34), (2) seroconverted ≥1 islet autoantibody without...
Abstract There is an established, link between psychosis and metabolic abnormalities, such as altered glucose metabolism dyslipidemia, which often precede the initiation of antipsychotic treatment. It known that obesity-associated disorders are promoted by activation specific cannabinoid targets (endocannabinoid system (ECS)). Our recent data suggest there a change in circulating lipidome at onset first episode (FEP). With aim characterizing involvement central peripheral ECSs, their mutual...
T cell activation, proliferation, and differentiation involve metabolic reprogramming resulting from the interplay of genes, proteins, metabolites. Here, we aim to understand pathways involved in activation functional human CD4+ subsets (T helper [Th]1, Th2, Th17, induced regulatory [iTreg] cells). combine genome-scale modeling, gene expression data, targeted non-targeted lipidomics experiments, together with vitro knockdown show that cells undergo specific changes during differentiation. In...
Abstract There is an established, albeit poorly-understood link between psychosis and metabolic abnormalities such as altered glucose metabolism dyslipidemia, which often precede the initiation of antipsychotic treatment. It known that obesity-associated disorders are promoted by peripheral activation endocannabinoid system (ECS). Our recent data suggest ECS dysregulation may also play a role in psychosis. With aim characterizing involvement central ECSs their mutual associations, here we...
ABSTRACT Previous metabolomics studies suggest that type 1 diabetes (T1D) is preceded by specific metabolic disturbances. Here we asked whether distinct patterns occur in peripheral blood mononuclear cells (PBMCs) of children later developing pancreatic β -cell autoimmunity or overt T1D. In a longitudinal cohort setting, PBMC metabolomic analysis was applied who either (1) progressed to T1D (PT1D, n=34), (2) seroconverted ≥1 islet autoantibody without progressing (P1Ab, n=27), (3) remained...
There is evidence of a positive association between per- and polyfluoroalkyl substances (PFAS) cholesterol levels in human plasma, which may be due to common reabsorption PFAS bile acids (BAs) the gut. Here we report development validation method that allows simultaneous, quantitative determination BAs using 150 uL or 20 sample. The involves protein precipitation 96-well plates. instrumental analysis was performed with ultra-performance liquid chromatography-tandem mass spectrometry...
There is evidence of a positive association between per- and polyfluoroalkyl substances (PFAS) cholesterol levels in human plasma, which may be due to common reabsorption PFAS bile acids (BAs) the gut. Here we report development validation method that allows simultaneous, quantitative determination BAs using 150 uL or 20 sample. The involves protein precipitation 96-well plates. instrumental analysis was performed with ultra-performance liquid chromatography-tandem mass spectrometry...
ABSTRACT T-cells are sentinels of adaptive cell-mediated immune responses. T-cell activation, proliferation and differentiation involves metabolic reprogramming involving the interplay genes, proteins metabolites. Here, we aim to understand pathways involved in activation functional human CD4 + subsets (Th1, Th2, Th17 iTregs). We combined genome-scale modeling, gene expression data, targeted non-targeted lipidomics experiments, together with vitro knockdown experiments showed that undergo...