A5029992045- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Genetics, Aging, and Longevity in Model Organisms
- Retinoids in leukemia and cellular processes
- Photosynthetic Processes and Mechanisms
- Traffic and Road Safety
- CRISPR and Genetic Engineering
- Metabolism and Genetic Disorders
- Genomics and Chromatin Dynamics
- Injury Epidemiology and Prevention
- Pluripotent Stem Cells Research
- Autophagy in Disease and Therapy
- Coenzyme Q10 studies and effects
- Trauma and Emergency Care Studies
University of Helsinki
2023
Tampere University
2009-2016
Tampere University Hospital
2009-2016
Mutations in mitochondrial oxidative phosphorylation complex I are associated with multiple pathologies, and has been proposed as a crucial regulator of animal longevity. In yeast, the single-subunit NADH dehydrogenase Ndi1 serves non-proton-translocating alternative enzyme that replaces I, bringing about reoxidation intramitochondrial NADH. We have created transgenic strains Drosophila express yeast NDI1 ubiquitously. Mitochondrial extracts from NDI1-expressing flies displayed...
Mitochondrial dysfunction is a significant factor in human disease, ranging from systemic disorders of childhood to cardiomyopathy, ischaemia and neurodegeneration. Cytochrome oxidase, the terminal enzyme mitochondrial respiratory chain, frequent target. Lower eukaryotes possess alternative respiratory-chain enzymes that provide non-proton-translocating bypasses for complexes I (single-subunit reduced nicotinamide adenine dinucleotide dehydrogenases, e.g. Ndi1 yeast) or III + IV [alternative...
Abstract A point mutation [technical knockout25t (tko25t)] in the Drosophila gene coding for mitoribosomal protein S12 generates a phenotype of developmental delay and bang sensitivity. tko25t has been intensively studied as an animal model human mitochondrial diseases associated with deficiency synthesis consequent multiple respiratory chain defects. Transgenic expression alternative oxidase (AOX) derived from Ciona intestinalis previously shown to mitigate toxicity inhibitors rescue mutant...
Culture of Drosophila expressing the steroid-dependent GeneSwitch transcriptional activator under control ubiquitous α-tubulin promoter was found to produce extensive pupal lethality, as well a range dysmorphic adult phenotypes, in presence high concentrations inducing drug RU486. Prominent among these cleft thorax, seen previously flies bearing mutant alleles nuclear receptor Ultraspiracle and many other mutants, notched wings, leg malformations, bristle abnormalities. Neither...
The Finnish national Traffic Safety Strategy 2022-2026 seeks to halve the number of road fatalities and serious injuries from 2020 2030. strategy states that better information on bicycle crashes is needed for safety promotion. aim this study was describe demographics, injury characteristics, alcohol involvement, helmet use severely injured cyclists compare single (falling alone or hitting a fixed object) collisions.