A5004329684- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Inertial Sensor and Navigation
- Neonatal and fetal brain pathology
- Advanced Data Compression Techniques
University of Oulu
2015-2025
Oulu University Hospital
2020
Accumulation of amyloid-β is a key neuropathological feature in brain Alzheimer's disease patients. Alterations cerebral haemodynamics, such as arterial impulse propagation driving the (peri)vascular CSF flux, predict future progression. We now present non-invasive method to quantify three-dimensional cardiovascular impulses human using ultrafast 10 Hz magnetic resonance encephalography. This technique revealed spatio-temporal abnormalities disease. The arrival latency and speed both...
Abstract Biomarkers sensitive to prodromal or early pathophysiological changes in Alzheimer’s disease (AD) symptoms could improve detection and enable timely interventions. Changes brain hemodynamics may be associated with the main clinical AD symptoms. To test this possibility, we measured variability of blood oxygen level-dependent (BOLD) signal individuals from three independent datasets (totaling 80 patients 90 controls). We detected a replicable increase BOLD populations, which...
During sleep, there is an increase in the brain cerebrospinal fluid (CSF) solute convection driven by physiological pulsations. Although main drivers of CSF flow, namely cardiac, respiratory, and vasomotor pulsations, become more powerful during relatively little information regarding their effects on flow velocity across human sleep. Here, we used functional magnetic resonance encephalography (MREG) to measure non-invasively changes water sleep tracking propagating ultrafast signal induced...
The brain is cleaned from waste by glymphatic clearance serving a similar purpose as the lymphatic system in rest of body. Impairment precedes protein accumulation and reduced cognitive function Alzheimer's disease (AD). Cardiovascular pulsations are primary driving force clearance. We developed method to quantify cardiovascular pulse propagation human with magnetic resonance encephalography (MREG). extended standard optical flow estimation three spatial dimensions, multi-resolution...
Abstract Resting-state functional MRI has shown potential for detecting changes in cerebral blood oxygen level-dependent signal patients with epilepsy, even the absence of epileptiform activity. Furthermore, it been suggested that coefficient variation mapping fast may provide a powerful tool identification intrinsic brain pulsations neurological diseases such as dementia, stroke and epilepsy. In this study, we used sequence (magnetic resonance encephalography) to acquire ten whole-brain...
Recent studies pinpoint visually cued networks of avalanches with MEG/EEG data. Co-activation pattern (CAP) analysis can be used to detect single brain volume activity profiles and hemodynamic fingerprints neuronal as sudden high signal peaks in classical fMRI In this study, we aimed dynamic patterns spreads the use ultrafast MR encephalography (MREG). MREG achieves 10 Hz whole sampling, allowing estimation spatial spread an avalanche, even inherent delay BOLD signal. We developed a novel...
Abstract Respiratory brain pulsations pertaining to intra-axial hydrodynamic solute transport are markedly altered in focal epilepsy. We used optical flow analysis of ultra-fast functional magnetic resonance imaging (fMRI) data investigate the velocity characteristics respiratory impulse propagation patients with epilepsy treated antiseizure medication (ASM) (medicated epilepsy; ME, n = 23), drug-naïve at least one seizure (DN, 19) and matched healthy control subjects (HC, 75). detected two...
A method and implementation are presented to achieve a thousand fold speed-up for seeking of large files in commonly used compressed neuroimaging data format NIfTI. Such technologies not currently available this research field while they would make the everyday work hundreds researchers experts much smoother faster. The includes creation novel index structure order speed-up. With random seek simulations, we demonstrate that over hundred up even five can be reached compared implementations....