Lieke Numan

ORCID: 0000-0002-5896-7738
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About
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Research Areas
  • Mechanical Circulatory Support Devices
  • Cardiac Structural Anomalies and Repair
  • Cardiac Arrest and Resuscitation
  • Heart Failure Treatment and Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Non-Invasive Vital Sign Monitoring
  • Hemodynamic Monitoring and Therapy
  • Fuel Cells and Related Materials
  • Healthcare Technology and Patient Monitoring
  • Enhanced Recovery After Surgery
  • Heart Rate Variability and Autonomic Control
  • ECG Monitoring and Analysis
  • Congenital Heart Disease Studies
  • IL-33, ST2, and ILC Pathways
  • Smart Grid Energy Management
  • Blood Pressure and Hypertension Studies
  • Cardiovascular and exercise physiology
  • Hip and Femur Fractures
  • Fault Detection and Control Systems
  • Control Systems and Identification
  • Public Health and Nutrition
  • Cardiovascular Function and Risk Factors
  • Climate Change and Health Impacts

University Medical Center Utrecht
2019-2024

Utrecht University
2019-2024

Heidelberg University
2022-2023

University Hospital Heidelberg
2022-2023

University of Twente
2019-2020

Background Hospital stays after major surgery are shorter than ever before. Although enhanced recovery and early discharge have many benefits, some complications will now first manifest themselves in home settings. Remote patient monitoring with wearable sensors the days hospital may capture clinical deterioration earlier but is largely uncharted territory. Objective This study aimed to assess technical feasibility of patients, discharged esophagectomy, being remotely monitored at a wireless...

10.2196/21705 article EN cc-by JMIR Perioperative Medicine 2020-10-29

Since the withdrawal of HeartWare (HVAD) from global market, there is an ongoing discussion if and which patients require prophylactically exchange for a HeartMate 3 (HM3). Therefore, it important to study outcome differences between HVAD HM3 patients. Because centres differ in patient selection standard care, we performed propensity score (PS)-based including that implanted both devices aimed identify are at highest risk.

10.1002/ehf2.14308 article EN cc-by-nc ESC Heart Failure 2023-02-16

Abstract Aims Left ventricular assist device therapy has become the cornerstone in treatment of end‐stage heart failure and is increasingly used as destination next to bridge transplant or recovery. HeartMate 3 (HM3) HeartWare (HVAD) are centrifugal continuous flow devices implanted intrapericardially most commonly worldwide. No randomized controlled trials have been performed yet. Analysis based on large registries may be considered best alternative but disadvantage different standard care...

10.1002/ehf2.13267 article EN ESC Heart Failure 2021-02-26

Late right heart failure (LRHF) is a common complication during long-term left ventricular assist device (LVAD) support. We aimed to identify risk factors for LRHF after LVAD implantation.Patients undergoing primary implantation between 2006 and 2019 surviving the perioperative period were included this study (n = 261). Univariate Cox proportional hazards analysis was used assess association of clinical covariates LRHF, stratified type. Variables with p < 0.10 entered multivariable model. In...

10.1111/aor.14537 article EN cc-by-nc-nd Artificial Organs 2023-04-10

Soluble suppression of tumorigenicity-2 (sST2) predicts mortality in patients with heart failure. The predictive value sST2 a left ventricular assist device remains unknown. Therefore, we studied the relationship between and outcome after implantation.

10.1161/jaha.123.029827 article EN cc-by-nc-nd Journal of the American Heart Association 2024-01-09

Non-invasive remote patient monitoring is an increasingly popular technique to aid clinicians in the early detection of worsening heart failure (HF) alongside regular follow-ups. However, previous studies have shown mixed results performance such systems. Therefore, we developed and evaluated a personalized algorithm aimed at increasing positive-predictive-value (PPV) (i.e. alarm quality) compared with simple rule-of-thumb moving average convergence-divergence algorithms (MACD).In this...

10.1093/ehjdh/ztad049 article EN cc-by-nc European Heart Journal - Digital Health 2023-08-22

The number of patients on left ventricular assist device (LVAD) support increases due to the growing with end-stage heart failure and limited donor hearts. Despite improving survival rates, frequently suffer from adverse events such as cardiac arrhythmia major bleeding. Telemonitoring is a potentially powerful tool early detect deteriorations may further improve outcome after LVAD implantation. Hence, we developed personalized algorithm remotely monitor HeartMate3 (HM3) pump parameters...

10.1093/ehjdh/ztad062 article EN cc-by-nc European Heart Journal - Digital Health 2023-10-25

The prevalence of (hyper)polypharmacy in patients on left ventricular assist device (LVAD) support and its effect clinical outcomeis unknown. Therefore, we aimed to determine the LVAD evaluate association with mortality complications. 210 aged ≥40 years who received a primary implantation between 2011 2019 were included for analysis. Polypharmacy hyperpolypharmacy defined as concomitant use 5–9 ≥10 medications at discharge after implantation, respectively. Cause specific cox regression was...

10.1016/j.ahjo.2022.100233 article EN cc-by-nc-nd American Heart Journal Plus Cardiology Research and Practice 2022-12-01

Abstract This study aims to associate the incidence of postoperative vasoplegia and short-term survival implantation various left ventricular assist devices differing in hemocompatibility flow profiles. The overall was 25.3% (73/289 patients) 30.3% (37/122), 25.0% (18/72), 18.9% (18/95) axial (AXF), centrifugal (CF), with artificial pulse (CFAP) group, respectively. Vasoplegia associated longer intensive care (ICU) hospital length stay (LOS) mortality. ICU in-hospital LOS 1-year mortality...

10.1007/s12265-023-10476-5 article EN cc-by Journal of Cardiovascular Translational Research 2024-02-01

Algorithms to monitor pump parameters are needed further improve outcomes after left ventricular assist device (LVAD) implantation. Previous research showed a restored circadian rhythm in patients on HeartWare (HVAD) support. Circadian patterns HeartMate3 (HM3) were not studied before, but this is important for the development of LVAD monitoring algorithms. Hence, we aimed describe HM3 and their relation heart rate (HR).18 included study. data retrieved at high frequency (one sample per 1 or...

10.1111/aor.14628 article EN cc-by-nc Artificial Organs 2023-08-28

Abstract Background Soluble suppression of tumorigenicity-2 (sST2) predicts mortality in heart failure patients. The predictive value sST2 left ventricular assist device (LVAD) patients remains unknown. Therefore, we studied the relationship between and outcome after LVAD implantation. Methods Patients implanted January 2015 December 2022 were included. Survival with normal elevated pre-operative levels was compared using Kaplan-Meier analysis. post-operative sST2, survival right (RHF)...

10.1101/2023.02.06.23285564 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2023-02-08

<sec> <title>BACKGROUND</title> Hospital stays after major surgery are shorter than ever before. Although enhanced recovery and early discharge have many benefits, some complications will now first manifest themselves in home settings. Remote patient monitoring with wearable sensors the days hospital may capture clinical deterioration earlier but is largely uncharted territory. </sec> <title>OBJECTIVE</title> This study aimed to assess technical feasibility of patients, discharged...

10.2196/preprints.21705 preprint EN 2020-06-22

Abstract Background Telemonitoring of body weight, blood pressure and heart rate has extensively been used to facilitate early recognition failure (HF) decompensations in order prevent hospital admissions. Mixed results have shown by different clinical trials regarding the effectiveness telemonitoring HF management. It is recognized that decompensation starts with an increase intra cardiac filling pressure. The relationship between daily pulmonary artery (PAP) values measurements weight not...

10.1093/eurheartj/ehac544.1092 article EN European Heart Journal 2022-10-01
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