A5080895294- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Transplantation: Methods and Outcomes
- Infective Endocarditis Diagnosis and Management
- Heart Failure Treatment and Management
- Intensive Care Unit Cognitive Disorders
- Cardiac Ischemia and Reperfusion
- Cardiac and Coronary Surgery Techniques
- Cardiac pacing and defibrillation studies
- Organ Transplantation Techniques and Outcomes
- Cardiac Health and Mental Health
- Orthopedic Infections and Treatments
- Pericarditis and Cardiac Tamponade
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Musculoskeletal Disorders and Rehabilitation
- Long-Term Effects of COVID-19
- Organ and Tissue Transplantation Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cerebrovascular and Carotid Artery Diseases
- Medical Practices and Rehabilitation
Ludwig-Maximilians-Universität München
2013-2025
German Centre for Cardiovascular Research
2016-2025
Heart and Diabetes Center North Rhine-Westphalia
2023-2024
Ruhr University Bochum
2023-2024
Stanford Medicine
2018-2020
Stanford University
2018-2020
University of California, San Francisco
2016-2018
University of San Francisco
2017
Sabin Vaccine Institute
2017
University Medical Center Hamburg-Eppendorf
2016
<b>Background</b> This retrospective single-center study aimed to analyze transfusion requirements, coagulation parameters, and outcome parameters in patients undergoing lung transplantation (LuTx) with intraoperative extracorporeal circulatory support, comparing cardiopulmonary bypass (CPB), membrane oxygenation (ECMO). <b>Methods</b> Over a 3-year period, 49 of total 188 LuTx recipients were identified being set intraoperatively on either conventional CPB (<i>n</i> = 22) or ECMO 27)....
OBJECTIVESTherapy refractory cardiogenic shock is associated with dismal outcome. Percutaneous implantation of an extracorporeal life support (ECLS) system achieves immediate cardiopulmonary stabilization, sufficient end-organ perfusion and reduction subsequent multiorgan failure (MOF).
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component. Molecular pathways involving homeodomain transcription factor Shox2 control development and function of conduction system in mouse zebrafish. Here we report analysis human SHOX2 as potential susceptibility gene for early-onset AF. To identify causal variants define underlying mechanisms, results from 378 patients AF before age 60 years were analyzed compared to 1870 controls or reference...
Aim: Arterial stiffness is a significant risk factor for many cardiovascular diseases, including abdominal aortic aneurysms (AAA). Nicotine, the major active ingredient of e-cigarettes and tobacco smoke, induces acute vasomotor effects that may temporarily increase arterial stiffness. Here, we investigated long-term nicotine exposure on structural Methods: Mice (C57BL/6) were infused with 40 days (20mg/kg/day). thoracic (TS) (AS) segments was analyzed using ultrasound (PWV, pulse wave...
Since the withdrawal of HeartWare (HVAD) from global market, there is an ongoing discussion if and which patients require prophylactically exchange for a HeartMate 3 (HM3). Therefore, it important to study outcome differences between HVAD HM3 patients. Because centres differ in patient selection standard care, we performed propensity score (PS)-based including that implanted both devices aimed identify are at highest risk.
Diagnosis of prosthetic graft infection after cardiac and proximal aortic surgery is a challenge. Besides technical considerations, redo associated with substantial morbidity mortality. Therefore, an accurate diagnosis mandatory. We report on our experience hybrid 18-fluorodeoxyglucose positron emission tomography (18F-FDG PET)/computed (CT) imaging, which increasingly used to diagnose infections in the detection surgery. Twenty-six patients who underwent 18F-FDG PET/CT imaging between...
No guidelines for mechanical circulatory support in patients with therapy-refractory cardiogenic shock and multiorgan failure including ongoing cardiopulmonary resuscitation (CPR) exist. To achieve immediate stabilization, we established an interdisciplinary concept on-site percutaneous extracorporeal life (ECLS) implantation.From February 2012 to November 2014, 96 were deemed eligible ECLS implantation. Establishing was successful 87 (mean age 54 ± 13 years, 16% female, initial flow 4.4 0.9...
Abstract Background The number of patients presenting with acute myocardial infarction (AMI) and being untreatable by interventional cardiologists increased during the last years. Previous experience in emergency coronary artery bypass grafting (CABG) these spurred us towards a more liberal acceptance for surgery. Following prospective protocol, were operated on further analysed. Methods Within two year interval, 127 (38 female, age 68±12 years, EuroScore (ES) II 6.7±7.2%) AMI (86...
Extracorporeal membrane oxygenation (ECMO) is increasingly used in COVID-19-related pulmonary failure and the number of patients recovering from COVID-19 growing. Here, we assess survival recovery 6 months after ECMO for COVID-19. From April 2020 to September 2021, n = 60 (60.5 [51.0-65.0] years, 23.3% female) were treated with venovenous/venoarterial 41.7% weaned off ECMO, survival-to-discharge was 40.0% (n 24). Age (63.0 [60.0-66.8] vs. 55.0 [43.8-60.0] p < 0.001), vasoactive support...
Different revascularization strategies for patients with acute myocardial infarction (AMI) exist. It remains unclear whether ventricular unloading using cardiopulmonary bypass (CPB) or extracorporeal life support (ECLS) has an impact on early postischaemic function. Here, we report the results of approach a miniaturized CPB in well-established animal model AMI. In randomized fashion, 30 male Wistar rats were assigned to temporary left anterior descending (LAD) ligation (30 min) followed by...
This study was meant to analyse the centre experience of Munich Lung Transplant Group in lung transplantation patients with severe pulmonary hypertension. Outcome data focus on survival and right heart remodelling.All receiving a transplant between 10/2010 08/2016 were retrospectively analysed (n = 343). Patients categorised into individuals or without pre-operative hypertension (PH; mPAP ≥ 35 mm Hg 25 cardiac index < 2.0 L/min/m2 ). Among those, PH secondary disease (Nice Class III)...
Venoarterial extracorporeal life support (ECLS) has emerged as a potentially life-saving treatment option in therapy-refractory cardiocirculatory failure, but longer-term outcome is poorly defined. Here, we present comprehensive follow-up analysis covering all major organ systems.From February 2012 to December 2016, 180 patients were treated with ECLS for cardiogenic shock or cardiac arrest. The 30-day survival was 43.9%, and survivors (n = 79) underwent the assessment of medium-term...
BACKGROUND: Survival rates of out-of-hospital cardiac arrest remain poor. Bystander cardiopulmonary resuscitation (CPR) is crucial for survival and feedback devices could improve its quality. OBJECTIVE: We investigated the quality chest compression when using Cardio First AngelTM (CFA) feedb ack device compared to standard basic life support (BLS). The analysis focused on laymen. METHODS: Laymen without (n= 43) with 96) explanation device, medical students 128) staff 27) performed 60 seconds...