A5011070572- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Infective Endocarditis Diagnosis and Management
- Colorectal Cancer Surgical Treatments
- Cardiac Valve Diseases and Treatments
- Enhanced Recovery After Surgery
- Blood transfusion and management
- Health Systems, Economic Evaluations, Quality of Life
- Aortic aneurysm repair treatments
- Erythropoietin and Anemia Treatment
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Acute Kidney Injury Research
- Cardiac Imaging and Diagnostics
- Frailty in Older Adults
- Cardiac Arrhythmias and Treatments
- Music Therapy and Health
- Blood groups and transfusion
- Health and Medical Research Impacts
- Cervical and Thoracic Myelopathy
- Global Health Care Issues
- Abdominal Surgery and Complications
Amphia Ziekenhuis
2019-2025
St. Antonius Ziekenhuis
2014-2017
University Medical Center Utrecht
2017
Nieuwegein Fonds
2016
Pain and Rehabilitation Medicine
2015
Medisch Centrum Haaglanden
2013
Sint Lucas Andreas Hospital
2009
Universität Hamburg
1988
To assess the association of systemic inflammation and outcome after major abdominal surgery.Major surgery carries a high postoperative morbidity mortality rate. Studies suggest that is associated with unfavorable outcome.Levels C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α inflammatory response syndrome (SIRS) were assessed in 137 patients undergoing surgery. Blood samples drawn on days 0, 1, 3, 7, SIRS was scored during 48 hours Primary composite mortality,...
Differences in socioeconomic status (SES) may influence long-term physical, psychological, and cognitive health outcomes of ICU survivors. However, the relationship between SES these three is rarely studied. The aim this study was to investigate associations occurrence 1-year post-ICU. Prospective cohort study. Seven Dutch ICUs. Patients 16 years old or older admitted for greater than equal 12 hours July 2016 March 2020 completed questionnaires, relatives if patients could not complete them...
Introduction Major surgery triggers an innate immune response that can become excessive, leading to suppression and increased risk of infection. Neutrophils are crucial in this response, changes their phenotype associated with the severity response. This study examines effect major on neutrophil phenotypes using fully automated flow cytometry. Methods In prospective single-center cohort study, adult patients undergoing either pancreaticoduodenectomy or on-pump coronary artery bypass grafting...
In anterior cervical spine surgery a retractor is obligatory to approach the spine. Previous studies showed an increase of endotracheal tube cuff pressure after placement retractor. It known that high increases incidence postoperative dysphagia, hoarseness, and sore throat. However, until now no evidence supports fact whether adjusting during will prevent this comorbidity. We present design randomized controlled trial determine dysphagia.177 patients (aged 18-90 years) scheduled for on 1 or...
Rationale: Despite functional impairments, intensive care unit (ICU) survivors can perceive their quality of life as acceptable. Objectives: To investigate discrepancies between calculated health, based on self-reported physical, mental, and cognitive functioning perceived 1 year after ICU admission. Methods: Data from an ongoing prospective multicenter cohort study, MONITOR-IC, were used. Patient-reported health (EuroQol visual analog scale; range, 0-100) post-ICU patients admitted to 11...
Postoperative complications increase mortality, disability and costs. Advanced understanding of the risk factors for postoperative is needed to improve surgical outcomes. This paper discusses rationale profile BIGPROMISE (biomarkers guide perioperative management outcome in high-risk surgery) cohort, that aims investigate factors, pathophysiology outcomes related complications. Adult patients undergoing major surgery two tertiary teaching hospitals. Clinical data blood samples are collected...
To assess whether preoperative statin therapy is associated with the risk of postoperative infection in patients undergoing cardiac surgery.520 surgery 2010 were retrospectively examined. Data regarding and antibiotic use prior to after available from hospital pharmacy information system. Cultures clinical data on antibiotics other than standard prophylactic studied identify infections up 30 days day surgery.370 (71.2 %) therapy. Overall, 82 (15.8 suffered which 11 surgical site infections....
Background To date, the pathophysiology of first-ever and recurrent stroke/TIA still remains unclear in young patients with embolic undetermined source (ESUS). Clinical studies long-term follow-up ESUS are necessary to investigate underlying this patient population, particular role new-onset atrial fibrillation. Aims Our aim was study (>10-year) clinical outcome (<50 years) ESUS. Methods This cohort included all aged ≤ 50 years who underwent transoesophageal echocardiography for...
Although elective surgery is generally safe, some procedures remain associated with an increased risk of complications. Improved preoperative stratification and earlier recognition these complications may ameliorate postoperative recovery improve long-term outcomes. The perioperative longitudinal study outcomes (PLUTO) cohort aims to establish a comprehensive biorepository that will facilitate research in this field. In profile paper, we discuss its design rationale opportunities for future...
Abstract The purpose of this study was to evaluate whether the baseline stress‐shortening data reflect contractile state adequately and give results comparable evaluation end‐systolic relationships using pharmacological manipulation afterload. Five groups were studied (total 152 patients): a control group 30 healthy volunteers, 32 patients after surgical correction infantile tetralogy Fallot, 50 treated for childhood malignancies with doxorubicin, 17 left ventricular hypertrophy due systemic...
Structured abstract Objective Chloroquine has been frequently administered for treatment of coronavirus disease 2019 but there are serious concerns about its efficacy and cardiac safety. Our objective was to investigate the pharmacokinetics safety chloroquine in hospitalized COVID-19 patients. Design A prospective observational study. Setting Dutch hospitals Patients admitted hospital COVID-19. Interventions Pharmacokinetic sampling Measurements The plasma concentrations desethylchloroquine...