A5002935937- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Family and Patient Care in Intensive Care Units
- Frailty in Older Adults
- Respiratory Support and Mechanisms
- Palliative Care and End-of-Life Issues
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- Organ Donation and Transplantation
- Traumatic Brain Injury and Neurovascular Disturbances
- Healthcare Technology and Patient Monitoring
- Healthcare Decision-Making and Restraints
- Noise Effects and Management
- Grief, Bereavement, and Mental Health
- Thermal Regulation in Medicine
- Phonocardiography and Auscultation Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Hematological disorders and diagnostics
- Climate Change and Health Impacts
- Hip and Femur Fractures
- Circadian rhythm and melatonin
- Cardiac, Anesthesia and Surgical Outcomes
Jeroen Bosch Ziekenhuis
2016-2025
Radboud University Nijmegen
2008-2023
Radboud University Medical Center
2003-2023
Leiden University Medical Center
2020
University Medical Center Utrecht
2019
Robert Bosch (Germany)
2012-2014
<h3>Importance</h3> Results of studies on use prophylactic haloperidol in critically ill adults are inconclusive, especially patients at high risk delirium. <h3>Objective</h3> To determine whether improves survival among delirium, which was defined as an anticipated intensive care unit (ICU) stay least 2 days. <h3>Design, Setting, and Participants</h3> Randomized, double-blind, placebo-controlled investigator-driven study involving 1789 treated 21 ICUs, nonpharmacological interventions for...
<h3>Importance</h3> One-year outcomes in patients who have had COVID-19 and received treatment the intensive care unit (ICU) are unknown. <h3>Objective</h3> To assess occurrence of physical, mental, cognitive symptoms among with at 1 year after ICU treatment. <h3>Design, Setting, Participants</h3> An exploratory prospective multicenter cohort study conducted ICUs 11 Dutch hospitals. Patients (N = 452) COVID-19, aged 16 years older, alive hospital discharge following admission to during first...
Rationale: Comprehensive studies addressing the incidence of physical, mental, and cognitive problems after ICU admission are lacking. With an increasing number survivors, improved understanding post-ICU is necessary. Objectives: To determine occurrence cooccurrence new among survivors 1 year admission, their impact on daily functioning, risk factors associated with 1-year outcomes. Methods: Prospective multicenter cohort study, including patients ⩾16 years age, admitted for ⩾12 hours...
Delirium incidence in intensive care unit (ICU) patients is high and associated with poor outcome. Identification of high-risk may facilitate its prevention.To develop validate a model based on data available at ICU admission to predict delirium development during patient's complete stay determine the predictive value this relation time development.Prospective cohort study 13 ICUs from seven countries. Multiple logistic regression analysis was used early prediction (E-PRE-DELIRIC) first...
High noise levels in the intensive care unit (ICU) are a well-known problem. Little is known about effect of on sleep quality ICU patients. The study aim to determine subjective quality. This was multicenter observational six Dutch ICUs. Noise recording equipment installed 2–4 rooms per ICU. Adult patients were eligible for 48 h after admission and followed up maximum five nights Exclusion criteria presence delirium and/or inability be assessed Sleep evaluated using Richards Campbell...
Abstract Background The role of haloperidol as treatment for ICU delirium and related symptoms remains controversial despite two recent large controlled trials evaluating its efficacy safety. We sought to determine whether when compared placebo in critically ill adults with reduces days coma improves delirium-related sequelae. Methods This multi-center double-blind, placebo-controlled randomized trial at eight mixed medical-surgical Dutch ICUs included (Intensive Care Delirium Screening...
Although mild hypothermia improves outcome in patients after out-of-hospital cardiac arrest, the cardiodepressive effects of may lead to secondary brain damage. This study was performed assess cerebral blood flow, oxygen extraction, and cerebrovascular reactivity changes partial pressure carbon dioxide arterial comatose arrest treated with hypothermia.Observational study.Tertiary care university hospital.Ten arrest.All were cooled 32-34 degrees C for 24 hrs. Cerebrovascular measured...
Accurate prediction of delirium in the intensive care unit (ICU) may facilitate efficient use early preventive strategies and stratification ICU patients by risk clinical research, but optimal model to is unclear. We compared predictive performance user convenience for (PRE-DELIRIC) (E-PRE-DELIRIC) determined value a two-stage calculation.This 7-country, 11-hospital, prospective cohort study evaluated consecutive adults admitted who could be reliably assessed using Confusion Assessment...
Early diagnosis and treatment has proven to be of utmost importance in the outcome sepsis patients. We compared accuracy neutrophil-lymphocyte count ratio (NLCR) conventional inflammatory markers patients admitted Intensive Care Unit (ICU).We performed a retrospective cohort study consisting 276 ICU with 388 without sepsis. NLCR as well C-reactive protein (CRP) level, procalcitonin (PCT) white blood cell (WBC) count, neutrophil lymphocyte on admission between non-sepsis To evaluate...
The acoustic environments in hospitals, particularly intensive care units (ICUs), are characterized by frequent high-level sound events which may negatively affect patient outcome. Many studies performed surveys, but the measurement protocol was not always reported detail, and scope of analysis limited selected mode level meters. Fewer systematically investigated noise sources ICUs employing an observer room, potentially bias measurement. In current study, soundscape ICU evaluated where...
Differences in socioeconomic status (SES) may influence long-term physical, psychological, and cognitive health outcomes of ICU survivors. However, the relationship between SES these three is rarely studied. The aim this study was to investigate associations occurrence 1-year post-ICU. Prospective cohort study. Seven Dutch ICUs. Patients 16 years old or older admitted for greater than equal 12 hours July 2016 March 2020 completed questionnaires, relatives if patients could not complete them...
To evaluate the effect of discussing personalized predictions long-term quality life (QoL) on patient and family experiences outcomes, ICU clinicians. We conducted a randomized clinical trial in two Dutch hospitals, assigning adult patients to receive usual care or intervention: expected QoL based validated prediction model, during meeting ICU. Primary outcome was experience with shared decision-making (CollaboRATE, range 0–100), evaluated < 3 days after meeting. Secondary outcomes included...
After ICU admission, the quality of life (QoL) survivors is often significantly lower compared to their peers. However, recent studies showed that this impaired QoL cannot be fully explained by physical, mental, and cognitive problems post-ICU, alluding other determinants QoL. Therefore, we aimed explore survivors' experienced 1-2 years focusing on factors beyond functional outcomes. Qualitative interview study. Seven hospitals in Netherlands. aged greater than or equal 16 admitted between...
To assess the value of F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) combined with CT in critically ill patients suspected having an infection.FDG-PET scans requested for evaluation a infection or inflammatory process ill, mechanically ventilated were analyzed (blinded final clinical diagnosis) and compared follow-up.Thirty-five FDG-PET/CT performed 33 ICU (28 adults 5 children), median age 58 years (range 1 month-72 years), analyzed. Twenty-one true positive. Three...
Objectives: Although patient’s health status before ICU admission is the most important predictor for long-term outcomes, it often not taken into account, potentially overestimating attributable effects of critical illness. Studies that did assess pre-ICU included specific patient groups or assessed one domain. Our aim was to explore physical, mental, and cognitive functioning, as well their quality life admission. Design: Baseline data were used from longitudinal prospective MONITOR-IC...
Determining the optimal timing for extubation can be challenging in intensive care. In this study, we aim to identify predictors failure critically ill patients with COVID-19.We used highly granular data from 3464 adult COVID multicenter Dutch Data Warehouse, including demographics, clinical observations, medications, fluid balance, laboratory values, vital signs, and life support devices. All intubated at least one attempt were eligible analysis. Transferred patients, admitted less than 24...
Determine differences in physical, mental and cognitive outcomes 1-year post-ICU between patients with persistent delirium (PD), non-persistent (NPD) no (ND).A longitudinal cohort study was performed adult ICU of two hospitals admitted July 2016-February 2020. Questionnaires on health, frailty QoL were completed regarding patients' pre-ICU health status post-ICU. Delirium data from total hospital stay. Patients divided PD (≥14 days delirium), NPD (<14 delirium) or ND patients.2400 both...
With survival rates of critical illness increasing, quality life measures are becoming an important outcome ICU treatment. Therefore, to study the impact on life, we explored before and 1 year after admission in different subgroups survivors.
To develop and externally validate a prediction model for ICU survivors' change in quality of life 1 year after admission that can support physicians preparing patients managing their expectations.Data from prospective multicenter cohort study (MONITOR-IC) were used.Seven hospitals the Netherlands.ICU survivors greater than or equal to 16 years old.None.Outcome was defined as life, measured using EuroQol 5D questionnaire. The developed based on data an academic hospital, multivariable linear...
OBJECTIVES: ICU survivors often suffer from long-lasting physical, mental, and cognitive health problems after hospital discharge. As several interventions that treat or prevent these already start during stay, patients at high risk should be identified early. This study aimed to develop a model for early prediction of post-ICU within 48 hours admission. DESIGN: Prospective cohort in seven Dutch ICUs. SETTING/PATIENTS: older than 16 years admitted greater equal 12 between July 2016 March...
Neuroinflammation is thought to play an important role in the pathogenesis of ICU-acquired delirium, but association between inflammatory and brain-specific proteins ICU delirium poor. We investigated whether or not serial determinations markers may improve this association. Critically ill patients with a high risk length stay at least 6 days were included study. Blood was drawn on 1, 2, 4 after admission analyzed for different inflammation several brain proteins. Differences courses over...