A5065646045- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Family Support in Illness
- Cancer-related cognitive impairment studies
- Patient-Provider Communication in Healthcare
- Palliative Care and End-of-Life Issues
- Colorectal Cancer Surgical Treatments
- Mitochondrial Function and Pathology
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- BRCA gene mutations in cancer
- Metabolism and Genetic Disorders
- Genetic Neurodegenerative Diseases
- Genetics and Neurodevelopmental Disorders
- Anorectal Disease Treatments and Outcomes
- Prostate Cancer Treatment and Research
- Systemic Sclerosis and Related Diseases
- Facial Nerve Paralysis Treatment and Research
- Global Cancer Incidence and Screening
- Economic and Financial Impacts of Cancer
- Health, psychology, and well-being
- Alzheimer's disease research and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Health Systems, Economic Evaluations, Quality of Life
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center
2020-2024
Radboud Institute for Molecular Life Sciences
2020-2022
University Hospital and Clinics
2020
St Vincent's Hospital
2017
The University of Sydney
2017
The University of Melbourne
2017
Southern California Institute of Architecture
2016
Engineering Arts (United States)
2016
Purpose Early breast cancer survivors (BCSs) report high unmet care needs, and easily accessible is not routinely available for this growing population. The Breast Cancer E-Health (BREATH) trial a Web-based self-management intervention to support the psychological adjustment of women after primary treatment, by reducing distress improving empowerment. Patients Methods This multicenter, randomized, controlled, parallel-group evaluated whether as usual (CAU) plus BREATH superior CAU alone....
In 9% to 34% of cancer patients, the fear recurrence becomes so overwhelming that it affects quality life. Clinicians need a brief questionnaire with cutoff point is able differentiate between high- and low-fearful survivors.This study investigated if Cancer Worry Scale (CWS) could serve as an instrument detect high levels in female breast survivors.One hundred ninety-four patients were assessed up 11 years after their primary treatment for cancer. The women returned questionnaires including...
Although long-term colorectal cancer (CRC) survivors generally report a good quality of life, fear recurrence (FCR) remains an important issue. This study investigated whether the Cancer Worry Scale (CWS) can detect high FCR, prevalence, and characteristics FCR in CRC survivors.Two hundred eleven patients who had undergone successful surgery period 2003-2010 Radboud University Medical Center Netherlands were asked to participate. All sent information letter plus questionnaires for collecting...
Targeted alpha-radiation therapy (TAT) with 225Ac-labeled prostate-specific membrane antigen (PSMA) ligands is a promising novel treatment option for metastatic castration-resistant prostate cancer (mCRPC) patients. However, limited data are available on efficacy, quality of life (QoL), and pretherapeutic biomarkers. The aim this study was to evaluate the efficacy 225Ac-PSMA TAT impact QoL in advanced mCRPC, explore predictive biomarkers tissue biopsies.Observational cohort including...
Abstract Objective Fear of cancer recurrence (FCR) is one the major existential unmet needs survivors. Due to growing availability evidenced‐based interventions for high FCR, valid and reliable brief measures FCR are needed. This study aimed validate 6‐item Cancer Worry Scale (CWS) establish a cut‐off score FCR. Methods Participants in this were 1033 survivors patients recruited as part 5 existing studies on involving with gastro‐intestinal stromal tumors, colorectal, breast, prostate...
High fear of cancer recurrence (FCR) is a frequently reported problem among patients. Previous research has shown that younger age associated with higher levels FCR. However, little attention been given to date about how FCR manifests itself adolescent and young adult (AYA) This study explores the prevalence, correlates high FCR, its association HRQoL in patients their late adolescence or adulthood.Seventy-three AYA patients, aged 18-35 years at diagnosis, consulted team Radboud University...
BackgroundThe aim of this nationwide cohort study was to examine the course symptoms and trajectories health-related quality life (HR-QoL) psychological distress during follow-up identify vulnerable patients.MethodsPatients with pathological stage I–III colorectal cancer (CRC) between 2013 2018 were included. Baseline characteristics collected from Netherlands Cancer Registry, patients completed European Organisation for Research Treatment QLQ-C30/CR29, Hospital Anxiety Depression Scale low...
Abstract Background This study assessed the course of fear cancer recurrence (FCR) in patients newly diagnosed with head and neck (HNC), identified FCR trajectories factors associated trajectories. Methods Six hundred seventeen HNC from NET‐QUBIC cohort completed Cancer Worry Scale‐6 at diagnosis, 3 6 months post‐treatment. were using Latent Class Growth Analysis. Associations explored between baseline demographic medical variables, coping self‐efficacy. Results Overall, decreased slightly...
Abstract Objective: Cancer comes with considerable psychological and emotional distress, which can persist long after initial treatment. Yet, few digital interventions targeting distress are available for patients cancer survivors. Cognitive bias modification (CBM) is a intervention designed to reduce by repeatedly training automatic processing of positive disease-specific information. We examined the feasibility, safety, clinical potential CBM as secondary prevention psychiatric disorders....
Abstract Background: An emerging group of patients with advanced cancer receiving systemic treatment lives long term ongoing uncertainty, but no valid measure uncertainty was available for this group. Our aims were to translate the Mishel Uncertainty in Illness Scale-Community (MUIS-C) into Dutch language and evaluate its psychometric properties treatment. Methods: Patients (N = 111) diverse diagnoses treatments (53% male, mean age 66 years) completed MUIS-C, which translated using a...
ABSTRACT Background Evidence on the efficacy of psychological interventions targeting cancer patients diagnosed with an adjustment disorder is scarce. Aims This study aimed to investigate and budget impact a tailored intervention program (AD‐program) (AD). Methods Patients ( n = 59) were randomised or control group. The AD‐program consisted three modules: psychoeducation (1–4 sessions) two additional modules (maximum 6 sessions per module) provided when needed. primary outcome was distress...
After ICU admission, the quality of life (QoL) survivors is often significantly lower compared to their peers. However, recent studies showed that this impaired QoL cannot be fully explained by physical, mental, and cognitive problems post-ICU, alluding other determinants QoL. Therefore, we aimed explore survivors' experienced 1-2 years focusing on factors beyond functional outcomes. Qualitative interview study. Seven hospitals in Netherlands. aged greater than or equal 16 admitted between...
Emotional disorders are characterized by cognitive biases towards negative stimuli, and a lack of positive ones. Therefore, we developed bias modification training, modifying approach-avoidance tendencies to diverse emotional pictures. In Study 1, training (pull negative, push pictures) was compared (vice versa) in 141 students. The pre-existing positivity remained after but reversed into negativity training. This effect transferred an attentional bias. affected neither mood nor...
In order to understand the multidimensional mechanism of fear cancer recurrence (FCR) and identify potential targets for interventions, it is important empirically test theoretical model FCR. This study aims at assessing validity Lee-Jones et al.'s FCR model.A total 1205 breast survivors were invited participate in this study. Participants received a questionnaire booklet including questionnaires on demographics psychosocial variables Data analysis consisted estimation direct indirect...
To validate the Dutch translation of Fear Progression Questionnaire-Short Form (FoP-Q-SF) for patients with systemic sclerosis (SSc). Although concerns about future are often expressed by SSc, there is no valid quantitative measure available to assess extent which SSc troubled those concerns.Measurement properties FoP-Q-SF were assessed using a cross-sectional design that included 215 SSc. Patients completed as well questionnaires on physical and psychological functioning. Psychometric...
Gastrointestinal stromal tumors (GIST) are rare and before 2000, patients had a dismal prognosis with median survival of less than year after tumor metastasis. However, the overall has increased to more five years following introduction imatinib other tyrosine kinase inhibitors (TKI). Little is known about psychosocial consequences treatment GIST, but this important because now treated live for longer. This cross-sectional study assessed quality life, distress, fear cancer recurrence or...
Frequency of scanning has accelerated in the era personalized medicine and is related, but not restricted, to exploding number clinical trials for new cancer treatments. Particularly drug trials, also practice, patients are followed up by scans frequently, which may vary from every 6 12 weeks until progression. The authors aimed raise awareness this underreported widely present "Sword Damocles" scan-related issue referred as 'scanxiety.'
Colorectal anastomotic leakage (AL) is a serious complication. Studies on the impact of AL health-related quality life (HRQoL) are scarce. We aimed to investigate association between and HRQoL in colorectal cancer patients up 2 years after diagnosis, evaluate whether associated with clinically relevant decrease over time.Patients diagnosed Stage I-III undergoing elective surgical resection primary anastomosis 2010 2017 were included. was evaluated using European Organization for Research...