A5078104775- Colorectal Cancer Surgical Treatments
- Frailty in Older Adults
- Colorectal Cancer Screening and Detection
- Nutrition and Health in Aging
- Cancer survivorship and care
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Hernia repair and management
- Hip and Femur Fractures
- Palliative Care and End-of-Life Issues
- Stoma care and complications
- Hip disorders and treatments
- Advances in Oncology and Radiotherapy
- Pelvic floor disorders treatments
- Gallbladder and Bile Duct Disorders
- Diverticular Disease and Complications
- Biliary and Gastrointestinal Fistulas
- Health Systems, Economic Evaluations, Quality of Life
- Pelvic and Acetabular Injuries
- Cancer Genomics and Diagnostics
- Aortic aneurysm repair treatments
- Bone fractures and treatments
- Pancreatic and Hepatic Oncology Research
Diakonessenhuis hospital
2014-2024
University Medical Center Utrecht
2023
Utrecht University
2023
Radboud University Nijmegen
2021
Radboud University Medical Center
2021
Elisabeth-TweeSteden Ziekenhuis
2014-2017
St. Antonius Ziekenhuis
2006-2008
Importance A watch-and-wait approach for patients with rectal cancer and a clinical complete response after neoadjuvant chemoradiotherapy or radiotherapy is associated better quality of life functional outcome. Nevertheless, prospective data on both parameters are scarce. Objective To prospectively evaluate outcome, including bowel, urinary, sexual function, following approach. Design, Setting, Participants total 278 near-complete were included in 2 cohort studies: single-center study (March...
According to the literature, conversion rate for laparoscopic cholecystectomy (LC) after endoscopic sphincterotomy (ES) cholecystodocholithiasis reaches 20%, at least when LC is performed 6 8 weeks afterward. It hypothesized that early planned ES prevents recurrent biliary complications and reduces operative morbidity hospital stay.All consecutive patients who underwent between 2001 2004 were retrospectively evaluated. Recurrent during waiting time LC, rate, postoperative complications, stay...
IntroductionRectal cancer surgery with neoadjuvant therapy is associated substantial morbidity. The present study describes the course of quality life (QOL) in rectal patients first 2 years after start treatment.Patients and MethodsWe performed a prospective within colorectal cohort including who were referred for chemoradiation or short-course radiotherapy underwent surgery. QOL was assessed using European Organization Research Treatment Cancer core questionnaire (EORTC QLQ-C30) QLQ-CR29)...
Background: The increasing sub-classification of cancer patients due to more detailed molecular classification tumors, and limitations current trial designs, require innovative research designs. We present the design, governance standing three comprehensive nationwide cohorts including pancreatic, esophageal/gastric, colorectal (NCT02070146). Multidisciplinary collection clinical data, tumor tissue, blood samples, patient-reported outcome (PRO) measures with a coverage, provides...
Currently, the preferred method for local excision of rectal polyps is transanal endoscopic microsurgery, avoiding resection. Transanal minimally invasive surgery a relatively new technique using disposable port in combination with conventional laparoscopic instruments. This less expensive as compared easy to learn, and available. Despite wide adoption surgery, date only few series on implementation use this are reported, detailed information effect fecal continence not available.The purpose...
Abstract Background Accurate detection of patients with minimal residual disease (MRD) after surgery for stage II colon cancer (CC) remains an urgent unmet clinical need to improve selection who might benefit form adjuvant chemotherapy (ACT). Presence circulating tumor DNA (ctDNA) is indicative MRD and has high predictive value recurrent disease. The MEDOCC-CrEATE trial investigates how many CC detectable ctDNA will accept ACT whether reduces the risk recurrence in these patients....
BackgroundThe aim of this nationwide cohort study was to examine the course symptoms and trajectories health-related quality life (HR-QoL) psychological distress during follow-up identify vulnerable patients.MethodsPatients with pathological stage I–III colorectal cancer (CRC) between 2013 2018 were included. Baseline characteristics collected from Netherlands Cancer Registry, patients completed European Organisation for Research Treatment QLQ-C30/CR29, Hospital Anxiety Depression Scale low...
Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked Netherlands Registry, serves as an infrastructure for scientific collecting additional patient-reported outcomes (PRO) biospecimens. Here we report on cohort developments investigate what extent PLCRC reflects "real-world". Clinical demographic characteristics of participants were compared with...
Abstract Introduction Most reports on the outcome of Watch-and-Wait (W&W) in rectal cancer come from expert centres. This study a broad implementation Netherlands. Material and Methods The process W&W is described patients registry between 2004 2022 analysed (regrowth, metastases, survival, organ preservation). Three equally sized chronological cohorts were compared to capture any differences during over time. Results was gradually implemented 18 high-volume hospitals coordinated by...
In thyroid surgery vessel division and haemostasis make up an important time consuming part of the operation. While presence recurrent laryngeal nerve limits liberal use diathermia, many arterial venous branches to from gland necessitates numerous conventional suture ligatures.This study evaluates effect using a sealing system on operation during surgery.A randomized clinical trial was performed between September 2005 October 2008 in teaching hospital. Forty patients undergoing total...
Care for elderly patients with low rectal cancer can pose dilemmas, because radical total mesorectal excision surgery comes high morbidity and mortality rates.The purpose of this study was to analyze the treatment cancer, comparing choices, guideline adherence, outcomes (≥75 years) younger (<75 years).Patient data were retrieved from hospital pathology database prospective colorectal surgically treated patients. Records reviewed nonadherence guidelines. Delivered modalities stage I III...
Most patients with colorectal cancer are elderly, but there few data on the optimal surgical treatment for this age group and most studies observational. We have reviewed characteristics of randomized trials reporting laparoscopic surgery to determine degree which elderly represented.A search was conducted NIH clinical trial registry ISRCTN register cancer. Trial end-points were extracted from website supplemented by published results where available.Of 52 protocols majority did not state...
Treatment decisions for elderly cancer patients can be challenging. A geriatric assessment may identify unknown medical conditions, give insight on patients' ability to tolerate treatment and guide decisions. Our aim was study the value of a consultation in oncological decision-making. Data referred clinical optimisation or due uncertainty regarding their optimal strategy were prospectively analysed. Outcome evaluations, non-oncological interventions suggested adaptations proposals...
VMS is a Dutch risk assessment tool for hospitalized older adults that includes short evaluation of four geriatric domains: delirium, undernutrition, physical impairments, and fall risk. We investigated whether the information derived from this has prognostic value outcomes colorectal surgery.All consecutive patients over age 70 years who underwent elective cancer surgery in three hospitals (2014-2016) were studied. The presence was scored prior to per domain as either 0 (risk absent) or 1...