A5069347180- Frailty in Older Adults
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Surgical Treatments
- Pregnancy and preeclampsia studies
- Enhanced Recovery After Surgery
- Cardiovascular Health and Disease Prevention
- Lung Cancer Research Studies
- Cancer survivorship and care
- Brain Metastases and Treatment
- Birth, Development, and Health
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Chronic Disease Management Strategies
- Colorectal Cancer Screening and Detection
- Estrogen and related hormone effects
- Pharmacogenetics and Drug Metabolism
- Health and Wellbeing Research
- Occupational and environmental lung diseases
- Economic and Financial Impacts of Cancer
- Maternal and fetal healthcare
- Clinical practice guidelines implementation
- Cardiovascular Issues in Pregnancy
- Emergency and Acute Care Studies
- Gestational Diabetes Research and Management
Haga Hospital
2017-2024
Leiden University Medical Center
2019-2024
Medisch Centrum Haaglanden
2024
University Medical Center Groningen
2010-2014
University of Groningen
2012-2014
Decision-making for older patients with lung cancer can be complex and challenging. A geriatric assessment (GA) may helpful is increasingly being used since 2005 when SIOG advised to incorporate this in standard work-up the elderly cancer. Our aim was evaluate value of a decision-making Between January 2014 April 2016, data on from two teaching hospitals Netherlands were entered prospective database. Outcome assessment, non-oncologic interventions, suggested adaptations oncologic treatment...
VMS is a Dutch risk assessment tool for hospitalized older adults that includes short evaluation of four geriatric domains: delirium, undernutrition, physical impairments, and fall risk. We investigated whether the information derived from this has prognostic value outcomes colorectal surgery.All consecutive patients over age 70 years who underwent elective cancer surgery in three hospitals (2014-2016) were studied. The presence was scored prior to per domain as either 0 (risk absent) or 1...
Early-onset preeclampsia is associated with premature cardiovascular disease. We previously demonstrated that femoral intima-media thickness (IMT) and markers of disease were increased in women 1 year after early-onset preeclampsia. The current study measured (progression of) IMT, risk factors endothelial cell dysfunction 4-5 years postpartum the same women.Case-control study.Formerly preeclamptic women.IMT carotid arteries was by ultrasound, as a marker subclinical atherosclerosis. Various...
Introduction Older patients have an increased risk of morbidity and mortality after colorectal cancer (CRC) surgery. Existing CRC surgical prediction models not incorporated geriatric predictors, limiting applicability for preoperative decision-making. The objective was to develop internally validate a predictive model based on including characteristics, severe postoperative complications elective surgery stage I–III in ≥70 years. Patients Methods: A prospectively collected database...
To determine the predictive value of lumbar skeletal muscle mass and density for postoperative outcomes in older women with advanced stage ovarian cancer.A multicenter, retrospective cohort study was performed ≥ 70 years old receiving surgery primary, cancer. Skeletal were assessed axial CT slices on level L3. Low defined as index < 38.50 cm2/m2. one standard deviation below mean (muscle attenuation 22.55 Hounsfield Units). The primary outcome any complication ≤ 30 days after surgery....
Objective. Preeclampsia is associated with cardiovascular atherosclerotic events later in life. Impaired arterial elasticity considered to be a marker of vascular (endothelial) dysfunction and involved the process. We investigated whether previously preeclamptic women have lower indices comparison controls. Design. Case-control study. Setting. University Medical Center Groningen, Netherlands. Sample. 14 non-pregnant history early-onset preeclampsia (cases) 16 (controls) an uncomplicated...
We aimed to study the pharmacokinetics and -dynamics of tamoxifen in older women with non-metastatic breast cancer.Data for this analysis were derived from CYPTAM (NTR1509) database. Patients stratified by age (age groups < 65 older). Steady-state trough concentrations measured tamoxifen, N-desmethyltamoxifen, 4-hydroxy-tamoxifen, endoxifen. CYP2D6 CYP3A4 phenotypes assessed all patients genotyping. Multiple linear regression models used analyze endoxifen variability. Outcome data included...
It is important to identify which older patients attending the emergency department are at risk of adverse outcomes introduce preventive interventions. This study aimed assess prognostic value a shortened screening instrument based on Dutch national Safety Management System [Veiligheidsmanagementsysteem (VMS)] guidelines for in patients.A cohort was performed including aged 70 years or who visited department. Adverse included hospital admission, return visits within 30 days, and 90-day...
In women with a history of preeclampsia skin autofluorescence as marker tissue AGEs accumulation is increased, supporting common causal metabolic or vascular link between and cardiovascular diseases.To investigate whether (AF), advanced glycation end-products (AGEs), elevated in 4-year severe preeclampsia.About 17 formerly preeclamptic 16 controls were included. Skin AF several traditional risk factors recorded.In comparison to controls, had higher the legs, body mass index (BMI), blood...
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