A5049081054- Frailty in Older Adults
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Neutropenia and Cancer Infections
- Intensive Care Unit Cognitive Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 and healthcare impacts
- Colorectal Cancer Surgical Treatments
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Long-Term Effects of COVID-19
- Statistical Methods in Clinical Trials
- Pharmacogenetics and Drug Metabolism
- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Innovative Microfluidic and Catalytic Techniques Innovation
- Brain Metastases and Treatment
- Colorectal Cancer Treatments and Studies
- Dementia and Cognitive Impairment Research
- Chronic Myeloid Leukemia Treatments
- Histone Deacetylase Inhibitors Research
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Screening and Detection
Reinier de Graaf Hospital
2018-2024
St. Jude Children's Research Hospital
2007-2012
Erasmus MC
2007-2012
Uppsala University
2007-2012
Erasmus MC Cancer Institute
2010-2011
Catharina Ziekenhuis
2010
Radboud University Nijmegen
2010
Erasmus University Rotterdam
2010
During the first wave of coronavirus disease 2019 (COVID-19) pandemic, older patients had an increased risk hospitalisation and death. Reports on association frailty with poor outcome have been conflicting.The aim present study was to investigate independent between in-hospital mortality in hospitalised COVID-19 Netherlands.This a multicentre retrospective cohort 15 hospitals Netherlands, including all aged ≥70 years, who were clinically confirmed February May 2020. Data collected...
Although older patients are at increased risk of developing grade 3 or higher chemotherapy-related toxic effects, no studies, to our knowledge, have focused on the association between effects and quality life (QOL) physical functioning.To investigate QOL functioning over time in patients.In this prospective, multicenter cohort study, aged 70 years who were scheduled receive chemotherapy with curative palliative intent a geriatric assessment included. Patients treated December 2015 2021....
The current practice of using body-surface area (BSA) in dosing anticancer agents was implemented clinical oncology half a century ago. By correcting for BSA, it generally assumed that cancer patients would receive dose particular cytotoxic drug associated with an acceptable degree toxicities without reducing the agent's therapeutic effect. More recently, doubt has arisen to this hypothesis, and many drugs, effects BSA on pharmacokinetics these have therefore been studied retrospectively. In...
Several constituents of cigarette smoke are known to interact with drug metabolizing enzymes and potentially affect treatment outcome substrate drugs. The purpose this study was determine the effects smoking on pharmacokinetics adverse irinotecan.A total 190 patients (49 smokers, 141 nonsmokers) treated irinotecan (90-minute intravenous administration a 3-week schedule) were evaluated for pharmacokinetics. Complete toxicity data available in subset 134 receiving 350 mg/m2 or 600 mg...
Docetaxel pharmacokinetic (PK) parameters, notably clearance and exposure (AUC), are characterized by large interindividual variability. The purpose of this study was to evaluate the effect PK-guided [area under plasma concentration versus time curve (AUC) targeted], individualized docetaxel dosing on variability in exposure.A limited sampling strategy combination with a validated population PK model, Bayesian analysis, predefined target AUC used. Fifteen patients were treated for at least 2...
Abstract Purpose: Irinotecan, the prodrug of SN-38, is extensively metabolized by cytochrome P450-3A4 (CYP3A4). A randomized trial was done to assess utility an algorithm for individualized irinotecan dose calculation based on a priori CYP3A4 activity measurements midazolam clearance test. Experimental Design: Patients were receive at conventional level 350 mg/m2 (group A) or doses equation consisting clearance, γ-glutamyl-transferase, and height B). Pharmacokinetics toxicities obtained...
Cigarette smoke is known to interact with the metabolism of several anticancer drugs. It may also affect incidence and severity adverse events efficacy chemotherapy. The main objective this study was examine effects smoking on pharmacokinetics toxicities patients treated docetaxel or paclitaxel.Smoking status, toxicity profiles, pharmacokinetic parameters (calculated by nonlinear mixed-effect modeling population analysis) were determined in 566 (429 nonsmokers 137 smokers) paclitaxel.Smokers...
VMS is a Dutch risk assessment tool for hospitalized older adults that includes short evaluation of four geriatric domains: delirium, undernutrition, physical impairments, and fall risk. We investigated whether the information derived from this has prognostic value outcomes colorectal surgery.All consecutive patients over age 70 years who underwent elective cancer surgery in three hospitals (2014-2016) were studied. The presence was scored prior to per domain as either 0 (risk absent) or 1...
Abstract Background as the coronavirus disease of 2019 (COVID-19) pandemic progressed diagnostics and treatment changed. Objective to investigate differences in characteristics, presentation outcomes older hospitalised COVID-19 patients between first second wave The Netherlands. Methods this was a multicentre retrospective cohort study 16 hospitals Netherlands including aged ≥ 70 years, for Spring 2020 (first wave) Autumn (second wave). Data included Charlson comorbidity index (CCI),...
A high incidence of delirium has been reported in older patients with Coronavirus disease 2019 (COVID-19). We aimed to identify determinants delirium, including the Clinical Frailty Scale, hospitalized COVID-19. Furthermore, we study association independent frailty in-hospital outcomes COVID-19 patients.
Abstract Background Treatment decisions concerning older patients can be very challenging and individualised treatment plans are often required in this heterogeneous group. In 2015 we have implemented a routine clinical care pathway for need of intensive treatment, including comprehensive geriatric assessment (CGA) that was used to support decision making. An ongoing prospective cohort study, the Triaging Elderly Needing (TENT) has also been initiated 2016 participants pathway, study...
Abstract Background It is important that healthcare professionals recognise cognitive dysfunction in hospitalised older patients order to address associated care needs, such as enhanced involvement of relatives and extra functional support. However, studies analysing medical records suggest have low awareness patients. In this study, we investigated the prevalence patients, percentage which was recognised by professionals, variables were with recognition. Methods A multicentre, nationwide,...
Abstract Purpose Viral mutations and improved prevention or treatment options may have changed the association of frailty with mortality throughout COVID-19 pandemic. We investigated how associations in-hospital pandemic in older people hospitalised for COVID-19. Methods The COVID-OLD study included patients aged ≥ 70 years during first (early 2020), second (late third 2021) fourth wave 2022). Based on clinical scale, were categorised as fit (1–3), pre-frail (4–5) frail (6–9). Associations...
Purpose: Because of its supposed inhibiting capacities uridine-diphosphate glucuronosyltransferase 1A (UGT1A)-mediated glucuronidation in rats, the antiepileptic drug valproic acid has been investigated as modulator irinotecan-induced delayed-type diarrhea rats. Here, we report on pharmacokinetic and pharmacodynamic effects this combination a cancer patient.Experimental Design: A patient who used was administered irinotecan (600 mg). To investigate dose-limiting hepatotoxicity encountered...
Delirium is a serious condition, which poses treatment challenges during hospitalisation for COVID-19. Improvements in testing, vaccination and might have changed patient characteristics outcomes through the pandemic. We evaluated whether prevalence risk factors delirium, association of delirium with in-hospital mortality pandemic.This study was part COVID-OLD 19 Dutch hospitals including patients ≥70 years first (spring 2020), second (autumn 2020) third wave 2021). Multivariable logistic...
Abstract Purpose The aim of the present study was to investigate characteristics and outcomes in vaccinated unvaccinated older patients hospitalized for COVID-19 infection. Methods A retrospective multicentre cohort among aged ≥70 years Results 263 82 were included. Vaccinated (median age 79 vs. 76 years; p < 0.001), more male (66.2% 53.7%; = 0.040), had comorbidities [median Charlson Comorbidity Index (CCI) 2 1; 0.016] frailer [Clinical Frailty Scale (CFS) ≥ 4 68% 49%; 0.015]. admitted...
Mannose-binding lectin (MBL) is important in the innate immune response. MBL2 gene polymorphisms affect MBL expression, and genotypes yielding low levels have been associated with an elevated risk for infections hematological cancer patients undergoing chemotherapy. However, these reported associations are inconsistent, data on solid tumors lacking. Here, we investigated effects of irinotecan-induced febrile neutropenia tumors.Irinotecan-treated were genotyped gene. Two promoter (-550 H/L...
To study the possible pharmacokinetic and pharmacodynamic interactions between irinotecan methimazole.A patient treated for colorectal cancer with single agent received methimazole co-medication Graves' disease. Irinotecan pharmacokinetics side effects were followed during a total of four courses (two two without methimazole).Plasma concentrations active metabolite SN-38 its inactive SN-38-Glucuronide both higher (a mean increase 14 67%, respectively) co-medication, compared to monotherapy....