Niels C. Gritters van den Oever
A5019118444- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- COVID-19 diagnosis using AI
- Sepsis Diagnosis and Treatment
- Family and Patient Care in Intensive Care Units
- Electrolyte and hormonal disorders
- Drug-Induced Ocular Toxicity
- Atrial Fibrillation Management and Outcomes
- Non-Invasive Vital Sign Monitoring
- Venous Thromboembolism Diagnosis and Management
- Frailty in Older Adults
- Diabetes Treatment and Management
- Hemodynamic Monitoring and Therapy
- Emergency and Acute Care Studies
- Central Venous Catheters and Hemodialysis
- Advanced Causal Inference Techniques
- Pancreatitis Pathology and Treatment
- SARS-CoV-2 and COVID-19 Research
- Inflammatory Biomarkers in Disease Prognosis
Treant Zorggroep
2020-2023
Determining the optimal timing for extubation can be challenging in intensive care. In this study, we aim to identify predictors failure critically ill patients with COVID-19.We used highly granular data from 3464 adult COVID multicenter Dutch Data Warehouse, including demographics, clinical observations, medications, fluid balance, laboratory values, vital signs, and life support devices. All intubated at least one attempt were eligible analysis. Transferred patients, admitted less than 24...
Objective Develop and validate models that predict mortality of patients diagnosed with COVID-19 admitted to the hospital. Design Retrospective cohort study. Setting A multicentre across 10 Dutch hospitals including from 27 February 8 June 2020. Participants SARS-CoV-2 positive (age ≥18) Main outcome measures 21-day all-cause evaluated by area under receiver operator curve (AUC), sensitivity, specificity, predictive value negative value. The age was explored comparison age-based rules used...
Abstract Background The objective of this study was to describe the prevalence, incidence, prognostic factors, and outcomes venous thromboembolism in critically ill patients receiving contemporary thrombosis prophylaxis. Methods We conducted a pooled analysis two prospective cohort studies. interest were in-hospital pulmonary embolism or lower extremity deep vein (PE-LDVT), nonleg (NLDVT), 90-day mortality. Multivariable logistic regression used evaluate association between predefined...
Objective To establish whether one can build a mortality prediction model for COVID-19 patients based solely on demographics and comorbidity data that outperforms age alone. Such could be precursor to implementing smart lockdowns vaccine distribution strategies. Methods The training cohort comprised 2337 inpatients from nine hospitals in Netherlands. clinical outcome was death within 21 days of being discharged. features were derived electronic health records collected during admission....
To compare survival of individuals with coronavirus disease 2019 (COVID-19) treated in hospitals that either did or not routinely treat patients hydroxychloroquine chloroquine. We analysed data COVID-19 nine the Netherlands. Inclusion dates ranged from 27 February to 15 May 2020, when Dutch national guidelines no longer supported use (hydroxy)chloroquine. Seven (hydroxy)chloroquine, two not. Primary outcome was 21-day all-cause mortality. performed a analysis using log-rank test and Cox...
Inhibition of dipeptidyl peptidase (DPP-)4 could reduce coronavirus disease 2019 (COVID-19) severity by reducing inflammation and enhancing tissue repair beyond glucose lowering. We aimed to assess this in a prospective cohort study.We studied 565 patients with type 2 diabetes the CovidPredict Clinical Course Cohort whether use DPP-4 inhibitor prior hospital admission due COVID-19 was associated improved clinical outcomes. Using crude analyses propensity score matching (on age, sex BMI), 28...
Large clinical trials on drugs for hospitalized coronavirus disease 2019 (COVID-19) patients have shown significant effects mortality. There may be a discrepancy with the observed real-world effect. We describe characteristics and outcomes of COVID-19 in Netherlands during 4 pandemic waves analyze association newly introduced treatments mortality, intensive care unit (ICU) admission, discharge alive.
Interleukin (IL)-6 inhibitors are administered to treat patients hospitalized with COVID-19. In 2021, due shortages, different dosing regimens of tocilizumab, and a switch sarilumab, were consecutively implemented. Using real-world data, we compare the effectiveness these IL-6 inhibitors.Hospitalized COVID-19, treated inhibitors, included in this natural experiment study. Sixty-day survival, hospital- intensive care unit (ICU) length stay, progression ICU or death compared between 8 mg/kg...
For mechanically ventilated critically ill COVID-19 patients, prone positioning has quickly become an important treatment strategy, however, is labor intensive and comes with potential adverse effects. Therefore, identifying which intubated patients will benefit may help allocate resources. From the multi-center Dutch Data Warehouse of ICU from 25 hospitals, we selected all 3619 episodes in 1142 invasively patients. We excluded longer than 24 h. Berlin ARDS criteria were not formally...
Abstract Background The identification of risk factors for adverse outcomes and prolonged intensive care unit (ICU) stay in COVID-19 patients is essential prognostication, determining treatment intensity, resource allocation. Previous studies have determined on admission only, included a limited number predictors. Therefore, using data from the highly granular multicenter Dutch Data Warehouse, we developed machine learning models to identify ICU mortality, ventilator-free days ICU-free...
Objectives To evaluate the relationship among dysnatraemia at hospital presentation and duration of admission, risk intensive care unit (ICU) admission all-cause mortality to assess underlying pathophysiological mechanism hyponatraemia in patients with COVID-19. Our hypothesis is that both hypernatraemia are associated adverse outcomes. Design Observational study. Setting Secondary care; 11 Dutch hospitals (2 university 9 general hospitals). Participants An analysis was performed within...
Objectives The aim of this multicentre COVID-PREDICT study (a nationwide observational cohort that aims to better understand clinical course COVID-19 and predict which patients should receive treatment type care) was determine the association between atrial fibrillation (AF) mortality, intensive care unit (ICU) admission, complications discharge destination in hospitalised patients. Setting Data from a historical eight hospitals (both academic non-academic) Netherlands January 2020 July 2021...
As coronavirus disease 2019 is a novel disease, treatment strategies continue to be debated. This provides the intensive care community with unique opportunity as population of patients requiring invasive mechanical ventilation relatively homogeneous compared other ICU populations. We hypothesize that novelty and uncertainty over its similarity noncoronavirus acute respiratory distress syndrome resulted in substantial practice variation between hospitals during first second waves...
During the COVID19 pandemic, older patients hospitalized for COVID-19 exhibited an increased mortality risk compared to younger patients. While ageing is associated with compromised immune responses and frailty, their contributions interplay remain understudied. This study investigated association between inflammatory markers potential modification by frailty among COVID-19.
ABSTRACT Objective Develop and validate models that predict mortality of SARS-CoV-2 infected patients admitted to the hospital. Design Retrospective cohort study Setting A multicenter across ten Dutch hospitals including from February 27 June 8 2020. Participants positive (age ≥ 18) Main Outcome Measures 21-day evaluated by area under receiver operatory curve (AUC), sensitivity, specificity, predictive value negative value. The age was explored comparison with age-based rules used in...