A5009376906- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Arrest and Resuscitation
- Aortic aneurysm repair treatments
- Chemokine receptors and signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Laser Design and Applications
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Lipoproteins and Cardiovascular Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune responses and vaccinations
- COVID-19 Clinical Research Studies
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Trauma and Emergency Care Studies
- Cardiac Valve Diseases and Treatments
- Inflammasome and immune disorders
- Immune cells in cancer
- Trauma Management and Diagnosis
Radboud University Nijmegen
2019-2025
Radboud University Medical Center
2019-2025
University Medical Center
2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2015
Bystander cardiopulmonary resuscitation (CPR) is crucial for survival after cardiac arrest but not performed in most cases. New, low-cost, and easily accessible training methods, such as virtual reality (VR), may reach broader target populations, data on achieved CPR skills are lacking.To compare quality between VR face-to-face training.Randomized noninferiority trial with a prospective randomized open blinded end point design. Participants were adult attendees from the science section of...
Even after fractional flow reserve (FFR)-guided complete revascularization, patients with myocardial infarction (MI) have high rates of recurrent major adverse cardiovascular events (MACE). These recurrences may be caused by FFR-negative high-risk nonculprit lesions.
BACKGROUND: Despite fractional flow reserve (FFR)–guided deferral of revascularization, recurrent events in patients with diabetes or after myocardial infarction remain common. This study aimed to assess the association between FFR-negative but high-risk nonculprit lesions and clinical outcomes. METHODS: is a patient-level pooled analysis prospective natural-history COMBINE (OCT-FFR) (Optical Coherence Tomography Morphologic Fractional Flow Reserve Assessment Diabetes Mellitus Patients)...
Abstract Background Intracoronary optical coherence tomography (OCT) provides detailed information on coronary lesions, but interpretation of OCT images is time-consuming and subject to interobserver variability. Objectives To develop validate a deep learning-based multiclass semantic segmentation algorithm for (OCT-AID). Methods A reference standard was obtained through manual annotation (guidewire artefact, lumen, side branch, intima, media, lipid plaque, calcified thrombus, plaque...
AimsIFN-beta (IFNβ) signalling is increased in patients with insufficient coronary collateral growth (i.e. arteriogenesis) and IFNβ hampers arteriogenesis mice. A downside of most pro-arteriogenic agents investigated the past has been their pro-atherosclerotic properties, rendering them unsuitable for therapeutic application. Interestingly, type I IFNs have also identified as cytokines treatment increases plaque formation accumulation macrophages. We therefore hypothesized that mAb therapy...
There is much debate on the use of angiotensin receptor blockers (ARBs) in severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected patients. Although it has been suggested that ARBs might lead to a higher susceptibility and severity SARS-CoV-2 infection, experimental data suggest may reduce lung injury via blocking angiotensin-II-mediated pulmonary permeability, inflammation, fibrosis. However, despite these hypotheses, specific studies patients are lacking. METHODS: The...
An association between atherosclerosis and coronary vasospasm has previously been suggested. However, to date, no conclusive data on the whole spectrum of these disorders have published.This study aimed define specific morphological features in patients with angina obstructive artery disease (ANOCA) due vasospasm.From February 2019 January 2020, we enrolled 75 referred our laboratory for a function test (CFT) ANOCA suspected vasomotor dysfunction. The CFT consisted an acetylcholine...
Objectives. To assess the safety and efficacy of pre-emptive treatment optical coherence tomography- (OCT-) derived vulnerable, non-flow-limiting, non-culprit lesions in patients with myocardial infarction (MI). Background. Intracoronary imaging OCT can aid decision to treat non-flow-limiting by identifying vulnerable plaques. Pre-emptive these might improve patient outcome “sealing” Bioresorbable vascular scaffolds (BVS) have theoretical benefit for this because they dissolve completely...
In patients with myocardial infarction, the decision to treat a nonculprit lesion is generally based on its physiological significance. However, deferral of revascularisation nonischaemic fractional flow reserve (FFR) values in these results less favourable outcomes compared stable coronary artery disease, potentially caused by vulnerable lesions. Intravascular optical coherence tomography (OCT) imaging allows for vivo morphological assessment plaque 'vulnerability' and might aid detection...
An increasing number of patients develop an atherothrombotic myocardial infarction (MI) in the absence standard modifiable risk factors (SMuRFs). Monocytes and macrophages regulate development atherosclerosis, monocytes can adopt a long-term hyperinflammatory phenotype by epigenetic reprogramming, which contribute to atherogenesis (called "trained immunity"). We assessed circulating monocyte function specific histone marks associated with trained immunity SMuRFless MI matched healthy...
Recurrent events after myocardial infarction (MI) are common and often originate from native non-culprit (NC) lesions that non-flow limiting. These consequently pose as targets to improve long-term outcome. It is, however, largely unknown whether these differ between sexes. The aim of this study was assess such potential differences.
Complete non-culprit (NC) revascularization may help reduce recurrent events after NSTEMI, especially if NC lesions would harbor high-risk plaque features similar to STEMI. The study aimed assess differences in fractional flow reserve (FFR)-negative morphology patients presenting with NSTEMI versus STEMI and the association of clinical outcome.
Objectives: Despite the undisputed impact of bystander cardiopulmonary resuscitation (CPR) in cardiac arrest, it is debated whether one should act as a rescuer after alcohol consumption, due to perceived adverse effects. We provide first objective data on use CPR-quality and performance. Methods: Adult attendees Lowlands music festival (August 2019, Netherlands) were randomized virtual reality or face-to-face CPR-training. Randomisation was stratified according level, measured using...