A5029858218- Analytical Chemistry and Chromatography
- Heme Oxygenase-1 and Carbon Monoxide
- Poisoning and overdose treatments
- Analytical Methods in Pharmaceuticals
- Forensic Toxicology and Drug Analysis
- Cardiac Arrest and Resuscitation
- Neonatal Health and Biochemistry
- Alcoholism and Thiamine Deficiency
- Cardiac Imaging and Diagnostics
- Sepsis Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Botulinum Toxin and Related Neurological Disorders
- Emergency and Acute Care Studies
- Computational Drug Discovery Methods
- Methemoglobinemia and Tumor Lysis Syndrome
- Alcohol Consumption and Health Effects
- Adrenal Hormones and Disorders
- Chemical Reaction Mechanisms
- Cardiac Ischemia and Reperfusion
- Cancer therapeutics and mechanisms
- Patient Safety and Medication Errors
- Cassava research and cyanide
- Pharmacological Effects and Toxicity Studies
- Advanced Glycation End Products research
- Bacterial Identification and Susceptibility Testing
University Medical Center Utrecht
2019-2025
Radboud University Medical Center
2008-2023
Radboud University Nijmegen
2008-2023
Interuniversity Center for Educational Research
2022
Utrecht University
1979-2021
Heidelberg University
1990-2021
Geneeskundige en Gezondheidsdienst
2021
University Hospital Heidelberg
1990-2021
Radboud Institute for Molecular Life Sciences
2014-2015
Netherlands Heart Institute
1990
In type 2 diabetes mellitus (T2DM), oxidative stress gives rise to endothelial dysfunction. Bilirubin, a powerful endogenous antioxidant, significantly attenuates dysfunction in preclinical experiments. The Gilbert syndrome is accompanied by mild and lifelong hyperbilirubinemia associated with only one third of the usual cardiovascular mortality risk. caused atazanavir treatment closely resembles syndrome. We thus hypothesized that would ameliorate vascular inflammation improve function...
The Medical Utilization Rates (MUR) can be applied to anticipate necessary medical resources at mass gatherings. MUR describes the number of patients per thousand attendees. aim this observational study was evaluate whether type music festival, Electronic Dance Music Festivals (EDMF) versus Mainstream, is related and drug-related incidents. We conducted a retrospective analysis patient data from Event Service B.V., Dutch company, providing emergency care many festivals in Netherlands. Data...
The Dutch Working Party on Antibiotic Policy (SWAB) in collaboration with relevant professional societies, has updated their evidence-based guidelines empiric antibacterial therapy of sepsis adults.Our multidisciplinary guideline committee generated ten population, intervention, comparison, and outcome (PICO) questions for adult patients sepsis. For each question, a literature search was performed to obtain the best available evidence assessed using Grading Recommendations Assessment,...
Objective— Statins may increase extracellular adenosine formation from monophosphate by enhancing ecto-5′-nucleotidase activity. This theory was tested in humans using dipyridamole-induced vasodilation as a read-out for local formation. Dipyridamole inhibits the transport of into cytosol resulting increased and subsequent vasodilation. In addition, we studied effect statin therapy forearm model ischemia-reperfusion injury. Methods Results— Volunteers randomly received rosuvastatin or placebo...
Preclinical results suggest therapeutic potential of mild hyperbilirubinemia in T2DM and cardiovascular disease. Translational data are limited, because an appropriate bilirubin formulation for parenteral human use is lacking. Considering its both clinical practice medical research the past, we explored feasibility to reintroduce translational experiments.We developed a preparation method accordance with good manufacturing evaluated applicability healthy volunteers (n = 8). Explorative...
Designer benzodiazepines (DBs) are an emerging class of new psychoactive substances. While structurally derived from pharmaceutical benzodiazepines, their toxicological profile is less clear. We investigated time trends in the rate DB poisonings and clinical toxicity. A retrospective observational study was performed on incidence poisonings, relative to all recreational drug reported Dutch Poisons Information Center (DPIC) 2010 2020. Time-trend analysis using Poisson regression. prospective...
Azide is a highly toxic chemical agent to human being. Accidental, but also intentional exposure azide occurs. To be able confirm ingestion, we developed method identify and quantify in biological matrices. Cyanide was included the evaluate suggested vivo production of cyanide after ingestion. matrices first derivatized by propionic anhydride form propionyl azide. Simultaneously, converted into hydrogen cyanide. After thermal rearrangement azide, ethyl isocyanate formed, separated together...
This translational randomized and vehicle-controlled cross-over study was performed to assess the impact of haem arginate treatment on oxygenase-1 induction, endothelial function insulin sensitivity in subjects with metabolic syndrome ( n = 14). Both periods consisted 5 days. Haem or vehicle (l-arginine) administered intravenously Days 1 3. Forearm blood flow response acetylcholine nitroglycerine measured by venous occlusion plethysmography (Day 3), a hyperinsulinaemic clamp procedure 5)....
Objective Inflammation-induced free radical release is important in the pathogenesis of several diseases, including atherosclerosis and sepsis. Heme oxygenase (HO) breaks down heme into carbon monoxide, iron, biliverdin. Biliverdin IXα directly converted to bilirubin by biliverdin reductase. Unconjugated a powerful antioxidant, elevated levels have beneficial effects preclinical models human cardiovascular disease. However, its impact during acute inflammation humans unknown. In present...