A5050251909- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- High Altitude and Hypoxia
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Muscle metabolism and nutrition
- Mesenchymal stem cell research
- Cardiovascular and exercise physiology
- Pancreatic function and diabetes
- Immune cells in cancer
- Tissue Engineering and Regenerative Medicine
- Sports Performance and Training
- Nutrition and Health in Aging
- Mitochondrial Function and Pathology
- S100 Proteins and Annexins
- Inflammatory Myopathies and Dermatomyositis
- Histone Deacetylase Inhibitors Research
- Neuroscience of respiration and sleep
- Immune Cell Function and Interaction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Cardiovascular and Diving-Related Complications
- Fibromyalgia and Chronic Fatigue Syndrome Research
Centre National de la Recherche Scientifique
2015-2024
Université Claude Bernard Lyon 1
2015-2024
Institut NeuroMyoGène
2009-2024
Inserm
2015-2024
Centre International de Recherche en Infectiologie
2022
Institut Cochin
2007-2015
Sorbonne Paris Cité
2012-2015
Université Paris Cité
2008-2015
Délégation Paris 5
2009-2015
Centre National pour la Recherche Scientifique et Technique (CNRST)
2014
Transcriptional adaptations to hypoxia are mediated by hypoxia-inducible factor (HIF)-1, a heterodimer of HIF-α and aryl hydrocarbon receptor nuclear translocator subunits. The HIF-1α HIF-2α subunits both undergo rapid hypoxia-induced protein stabilization bind identical target DNA sequences. When coexpressed in similar cell types, discriminating control mechanisms may exist for their regulation, explaining why do not substitute during embryogenesis. We report that, human lung epithelial...
Abstract Macrophages (MPs) exert either beneficial or deleterious effects on tissue repair, depending their activation/polarization state. They are crucial for adult skeletal muscle notably by acting myogenic precursor cells. However, these interactions have not been fully characterized. Here, we explored both in vitro and vivo, human, the of differentially activated MPs with cells (MPCs) during myogenesis regeneration. We showed that through differential secretion cytokines growth factors,...
US adults take between approximately 2,000 and 12,000 steps per day, a wide range of ambulatory activity that at the low could increase risk for developing chronic metabolic diseases. Dramatic reductions in physical induce insulin resistance; however, it is uncertain if how would influence peripheral sensitivity. We aimed to explore healthy, nonexercising subjects who went from normal level 2 wk display alterations including reduced To do this, ten healthy young men decreased their daily...
AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that plays central role in skeletal muscle metabolism. We used muscle-specific AMPKα1α2 double-knockout (mdKO) mice to provide direct genetic evidence the physiological importance AMPK regulating exercise capacity, mitochondrial function, and contraction-stimulated glucose uptake. Exercise performance was significantly reduced mdKO mice, with reduction maximal force production fatigue resistance. An increase proportion...
In skeletal muscle, new functions for vessels have recently emerged beyond oxygen and nutrient supply, through the interactions that vascular cells establish with muscle stem cells. Here, we demonstrate in human mouse endothelial (ECs) myogenic progenitor (MPCs) interacted together to couple myogenesis angiogenesis vitro vivo during regeneration. Kinetics of gene expression ECs MPCs sorted at different time points regeneration identified three effectors secreted by both MPCs. Apelin,...
Abstract Macrophage gene expression determines phagocyte responses and effector functions. plasticity has been mainly addressed in vitro models that do not account for the environmental complexity observed vivo. In this study, we show microarray profiling revealed a highly dynamic landscape of transcriptomic changes Ly6CposCX3CR1lo Ly6CnegCX3CR1hi macrophage populations during skeletal muscle regeneration after sterile damage. Systematic analysis time elapsed, much more than Ly6C status, was...
Chronic inflammation and fibrosis characterize Duchenne muscular dystrophy (DMD). We show that pro-inflammatory macrophages are associated with in mouse human DMD muscle. DMD-derived Ly6Cpos exhibit a profibrotic activity by sustaining fibroblast production of collagen I. This is mediated the high latent-TGF-β1 due to higher expression LTBP4, for which polymorphisms progression patients. Skewing macrophage phenotype via AMPK activation decreases ltbp4 macrophages, blunts latent-TGF-β1,...
Diabetes represents a major public health concern with considerable impact on human life and healthcare expenditures. It is now well established that diabetes characterized by severe skeletal muscle pathology limits functional capacity quality of life. Increasing evidence indicates also one the most prevalent disorders impaired regeneration, yet underlying mechanisms therapeutic treatments remain poorly established. In this review, we describe cellular molecular alterations currently known...
The cytokine interleukin-15 (IL-15) has been demonstrated to have anabolic effects in cell culture systems. We tested the hypothesis that IL-15 is predominantly expressed by type 2 skeletal muscle fibres, and resistance exercise regulates expression muscle. Triceps brachii, vastus lateralis quadriceps soleus biopsies were obtained from normally physically active, healthy, young male volunteers (n = 14), because these muscles are characterized having different fibre-type compositions. In...
IL-15 decreases lipid deposition in preadipocytes and the mass of white adipose tissue rats, indicating that may take part regulating this tissue. is expressed human skeletal muscle be a source plasma way regulate mass.The relation between mRNA expression, IL-15, was studied 199 humans divided into four groups on basis obesity type 2 diabetes. Furthermore, using DNA electrotransfer model, we assessed effect overexpression mice.In humans, multiple regression analysis showed negative...
Background: There is a considerable commercial market, especially within the sports community, claiming need for antioxidant supplementation. One argument supplementation in that physical exercise associated with increased reactive oxygen and nitrogen species (RONS) production, which may cause cell damage. However, RONS production also activate redox-sensitive signaling pathways transcription factors, subsequently, promote training adaptation. Purpose: Our aim was to investigate effects of...
Understanding the circuits that promote an efficient resolution of inflammation is crucial to deciphering molecular and cellular processes required tissue repair. Macrophages play a central role in regulation inflammation, resolution, repair/regeneration. Using model skeletal muscle injury repair, herein we identified annexin A1 (AnxA1) as extracellular trigger macrophage skewing toward pro-reparative phenotype. Brought into injured initially by migrated neutrophils, then overexpressed...
Mesenchymal stem cells (MSC) are known to repair broken heart tissues primarily through a paracrine fashion while emerging evidence indicate that MSC can communicate with cardiomyocytes (CM) tunneling nanotubes (TNT). Nevertheless, no link has been so far established between these two processes. Here, we addressed whether cell-to-cell communication processes and suffering more particularly those involving TNT control the regenerative function. In attempt mimic in vitro an injured...